Gene Page: DTNBP1

Summary ?
GeneID84062
SymbolDTNBP1
SynonymsBLOC1S8|DBND|HPS7|My031|SDY
Descriptiondystrobrevin binding protein 1
ReferenceMIM:607145|HGNC:HGNC:17328|Ensembl:ENSG00000047579|HPRD:06190|Vega:OTTHUMG00000014295
Gene typeprotein-coding
Map location6p22.3
Pascal p-value0.549
Sherlock p-value0.57
Fetal beta0.755
DMG1 (# studies)
eGeneCaudate basal ganglia
Hippocampus
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies3Link to SZGene
GSMA_IGenome scan meta-analysisPsr: 0.0159 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizotypy,schizophrenias,schizotypalClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 33.8114 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg23819836615663134DTNBP13.145E-4-0.1970.04DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10508654chr1023104638DTNBP1840620.14trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0042802identical protein bindingIPI15102850 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007601visual perceptionIEA-
GO:0006996organelle organizationISS-
GO:0050896response to stimulusIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0030424axonISSneuron, axon, Neurotransmitter (GO term level: 6)-
GO:0005634nucleusISS-
GO:0005737cytoplasmIEA-
GO:0005737cytoplasmISS-
GO:0042383sarcolemmaISS-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABI3NESH | SSH3BP3ABI family, member 3Two-hybridBioGRID16189514 
ARFIP2POR1ADP-ribosylation factor interacting protein 2Two-hybridBioGRID16189514 
BLOC1S1BLOS1 | FLJ39337 | FLJ97089 | GCN5L1 | MGC87455 | MICoA | RT14biogenesis of lysosomal organelles complex-1, subunit 1Affinity Capture-WesternBioGRID15102850 
BLOC1S2BLOS2 | FLJ30135 | MGC10120 | RP11-316M21.4biogenesis of lysosomal organelles complex-1, subunit 2-HPRD,BioGRID15102850 
BLOC1S3BLOS3 | FLJ26641 | FLJ26676 | HPS8 | RPbiogenesis of lysosomal organelles complex-1, subunit 3Affinity Capture-WesternBioGRID15102850 
CCND3-cyclin D3Two-hybridBioGRID16189514 
CMYA5C5orf10 | DKFZp451G182 | DKFZp451G223 | DTNBP2 | SPRYD2 | TRIM76cardiomyopathy associated 5-HPRD14688250 
CNOBCAS4L | FLJ11230cappuccino homolog (mouse)-HPRD15102850 
DGCR6LFLJ10666DiGeorge syndrome critical region gene 6-likeTwo-hybridBioGRID16189514 
DTNAD18S892E | DRP3 | DTN | FLJ96209 | LVNC1dystrobrevin, alpha-HPRD11316798 
DTNBMGC17163 | MGC57126dystrobrevin, beta-HPRD11316798 
MUTEDDKFZp686E2287 | MUmuted homolog (mouse)Muted interacts with Dysbindin.BIND15102850 
MUTEDDKFZp686E2287 | MUmuted homolog (mouse)Affinity Capture-Western
Two-hybrid		BioGRID15102850 
PLDNPA | PALLIDpallidin homolog (mouse)Pallidin interacts with Dysbindin.BIND15102850 
PLDNPA | PALLIDpallidin homolog (mouse)-HPRD,BioGRID15102850 
SNAPINSNAPAPSNAP-associated proteinAffinity Capture-Western
Two-hybrid		BioGRID15102850 
SNAPINSNAPAPSNAP-associated proteinSnapin interacts with Dysbindin.BIND15102850 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME MEMBRANE TRAFFICKING 12974All SZGR 2.0 genes in this pathway
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING 6031All SZGR 2.0 genes in this pathway
REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS 5327All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770415All SZGR 2.0 genes in this pathway
LIAO METASTASIS 539324All SZGR 2.0 genes in this pathway
GARCIA TARGETS OF FLI1 AND DAX1 DN 176104All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517309All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532309All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway