Gene Page: ULK1

Summary
GeneID  8408
Symbol  ULK1
Synonyms  ATG1|FLJ38455|UNC51|Unc51.1
Description  unc-51-like kinase 1 (C. elegans)
See related  HGNC:12558|MIM:603168|Ensembl:ENSG00000177169|HPRD:11933|
Locus tag  -
Gene type  protein-coding
Map location  12q24.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 7 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
BRPF30.900.92
UBN10.900.93
ARHGEF70.900.92
WDR370.900.91
C11orf410.890.93
DDI20.890.91
HTT0.880.90
ANKRD280.880.90
ATRN0.880.90
ABI20.880.91
Top 10 negatively co-expressed genes
FXYD1-0.66-0.68
HIGD1B-0.65-0.70
AF347015.31-0.65-0.68
MT-CO2-0.65-0.69
AF347015.21-0.64-0.71
TLCD1-0.64-0.67
C1orf54-0.63-0.76
S100A16-0.62-0.66
AC021016.1-0.62-0.65
CST3-0.62-0.66
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIPI11146101 
GO:0005524ATP bindingIEA-
GO:0004674protein serine/threonine kinase activityNAS9693035 
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0048675axon extensionIEAaxon (GO term level: 13)-
GO:0048671negative regulation of collateral sproutingIEAaxon (GO term level: 15)-
GO:0021707cerebellar granule cell differentiationIEAneuron, glutamate, Brain (GO term level: 15)-
GO:0031175neurite developmentIMPneuron, axon, neurite, dendrite (GO term level: 10)18007665 
GO:0021933radial glia guided migration of granule cellIEABrain, Glial (GO term level: 11)-
GO:0010506regulation of autophagyIMP17595159 
GO:0007265Ras protein signal transductionIEA-
GO:0007165signal transductionIEA-
GO:0008104protein localizationIMP16940348 
GO:0031623receptor internalizationIEA-
GO:0046777protein amino acid autophosphorylationIEA-
GO:0051386regulation of nerve growth factor receptor signaling pathwayIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043025cell somaIEAaxon, dendrite (GO term level: 4)-
GO:0043005neuron projectionIEAneuron, axon, neurite, dendrite (GO term level: 5)-
GO:0005829cytosolIDA11146101 
GO:0005624membrane fractionIEA-
GO:0005737cytoplasmNAS9693035 
GO:0005776autophagic vacuoleIDA17595159 
GO:0030659cytoplasmic vesicle membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GABARAPFLJ25768 | MGC120154 | MGC120155 | MM46GABA(A) receptor-associated protein-HPRD,BioGRID11146101 
GABARAPL2ATG8 | GATE-16 | GATE16 | GEF-2 | GEF2GABA(A) receptor-associated protein-like 2-HPRD,BioGRID11146101 
SDCBPMDA-9 | ST1 | SYCL | TACIP18syndecan binding protein (syntenin)-HPRD,BioGRID15014045 
SYNGAP1DKFZp761G1421 | KIAA1938 | RASA1 | RASA5 | SYNGAPsynaptic Ras GTPase activating protein 1 homolog (rat)-HPRD,BioGRID15014045 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-12814291435m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-142-5p477483m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-17-5p/20/93.mr/106/519.d4754821A,m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-25/32/92/363/367140914151Ahsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-26141414211A,m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-320455461m8hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-93.hd/291-3p/294/295/302/372/373/520474480m8hsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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