Gene Page: CUL4A

Summary
GeneID  8451
Symbol  CUL4A
Synonyms  -
Description  cullin 4A
See related  HGNC:2554|MIM:603137|Ensembl:ENSG00000139842|HPRD:07218|
Locus tag  RP11-391H12.1
Gene type  protein-coding
Map location  13q34
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SCYL10.860.81
TBC1D170.850.81
MAP7D10.850.82
PLA2G60.840.81
SPG70.840.79
AAMP0.830.77
TCF250.830.76
AGAP30.830.78
C16orf580.830.75
PEX140.820.78
Top 10 negatively co-expressed genes
AF347015.21-0.73-0.60
MT-CO2-0.67-0.55
AF347015.31-0.67-0.56
AF347015.8-0.66-0.55
MT-CYB-0.64-0.53
AF347015.2-0.63-0.49
AF347015.27-0.62-0.54
AF347015.15-0.62-0.53
MT-ATP8-0.61-0.58
AF347015.33-0.61-0.49
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI12504025 
GO:0031625ubiquitin protein ligase bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000082G1/S transition of mitotic cell cycleTAS8681378 
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0006281DNA repairIEA-
GO:0007050cell cycle arrestTAS8681378 
GO:0008285negative regulation of cell proliferationTAS8681378 
GO:0008629induction of apoptosis by intracellular signalsTAS8681378 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0031461cullin-RING ubiquitin ligase complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CAND1DKFZp434M1414 | FLJ10114 | FLJ10929 | FLJ38691 | FLJ90441 | KIAA0829 | TIP120 | TIP120Acullin-associated and neddylation-dissociated 1Affinity Capture-MS
Affinity Capture-Western
BioGRID12609982 
DDB1DDBA | UV-DDB1 | XAP1 | XPCE | XPE | XPE-BFdamage-specific DNA binding protein 1, 127kDaDDB1 interacts with CUL4A.BIND15448697 
DDB1 Interacts with CUL4A.BIND14739464 
DET1FLJ10103 | MGC126156 | MGC126157de-etiolated homolog 1 (Arabidopsis)Affinity Capture-WesternBioGRID14739464 
HSP90AA1FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2heat shock protein 90kDa alpha (cytosolic), class A member 1Affinity Capture-MSBioGRID12481031 
HSPA1AFLJ54303 | FLJ54370 | FLJ54392 | FLJ54408 | FLJ75127 | HSP70-1 | HSP70-1A | HSP70I | HSP72 | HSPA1 | HSPA1Bheat shock 70kDa protein 1AAffinity Capture-MSBioGRID12481031 
NEDD8FLJ43224 | MGC104393 | MGC125896 | MGC125897 | Nedd-8neural precursor cell expressed, developmentally down-regulated 8Affinity Capture-MSBioGRID12481031 
RBX1BA554C12.1 | MGC13357 | MGC1481 | RNF75 | ROC1ring-box 1ROC1 interacts with Cul4A.BIND15448697 
Affinity Capture-MSBioGRID12481031 
RFWD2COP1 | FLJ10416 | RNF200ring finger and WD repeat domain 2Affinity Capture-WesternBioGRID14739464 
RNF7CKBBP1 | ROC2 | SAGring finger protein 7-HPRD,BioGRID10230407 
TUBA1BK-ALPHA-1tubulin, alpha 1bAffinity Capture-MSBioGRID12481031 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-137115411611A,m8hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-142-5p107510821A,m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-377343349m8hsa-miR-377AUCACACAAAGGCAACUUUUGU
miR-410118211881Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-494109711041A,m8hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
miR-911201126m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.