Gene Page: SLC9A7
Summary ?
| GeneID | 84679 |
| Symbol | SLC9A7 |
| Synonyms | NHE-7|NHE7|SLC9A6 |
| Description | solute carrier family 9 member A7 |
| Reference | MIM:300368|HGNC:HGNC:17123|Ensembl:ENSG00000065923|HPRD:02297| |
| Gene type | protein-coding |
| Map location | Xp11.3|Xp11.3 |
| Fetal beta | -0.123 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0015385 | sodium:hydrogen antiporter activity | IDA | 11279194 | |
| GO:0015386 | potassium:hydrogen antiporter activity | IDA | 11279194 | |
| GO:0015299 | solute:hydrogen antiporter activity | IEA | - | |
| GO:0015297 | antiporter activity | IEA | - | |
| GO:0030955 | potassium ion binding | IEA | - | |
| GO:0042803 | protein homodimerization activity | TAS | 11279194 | |
| GO:0031402 | sodium ion binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006814 | sodium ion transport | IEA | - | |
| GO:0006811 | ion transport | IEA | - | |
| GO:0006813 | potassium ion transport | IEA | - | |
| GO:0006885 | regulation of pH | IDA | 11279194 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005794 | Golgi apparatus | IDA | 11279194 | |
| GO:0005802 | trans-Golgi network | IDA | 11279194 | |
| GO:0016020 | membrane | IEA | - | |
| GO:0016021 | integral to membrane | IDA | 11279194 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES | 413 | 270 | All SZGR 2.0 genes in this pathway |
| REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT | 241 | 157 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | 94 | 65 | All SZGR 2.0 genes in this pathway |
| YAGI AML SURVIVAL | 129 | 87 | All SZGR 2.0 genes in this pathway |
| WIERENGA STAT5A TARGETS UP | 217 | 131 | All SZGR 2.0 genes in this pathway |
| WIERENGA STAT5A TARGETS GROUP1 | 136 | 76 | All SZGR 2.0 genes in this pathway |