Gene Page: IRS4

Summary
GeneID  8471
Symbol  IRS4
Synonyms  IRS-4|PY160
Description  insulin receptor substrate 4
See related  HGNC:6128|MIM:603510|Ensembl:ENSG00000133124|HPRD:04620|
Locus tag  -
Gene type  protein-coding
Map location  Xq22.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0058 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MBP0.960.97
KIF1C0.920.90
SEPT40.900.91
FOXO40.890.85
MOBP0.890.92
SGMS20.870.89
PLEKHB10.860.92
PAIP2B0.850.72
DAAM20.850.89
TP53INP20.850.86
Top 10 negatively co-expressed genes
MED19-0.65-0.78
UBE2E3-0.64-0.77
PARP6-0.64-0.78
AC009133.1-0.64-0.78
NR2C2AP-0.63-0.82
PPP3CC-0.63-0.78
DUSP12-0.63-0.78
GSTA4-0.63-0.79
MLLT11-0.63-0.77
ING4-0.63-0.77
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005158insulin receptor bindingIEA-
GO:0005070SH3/SH2 adaptor activityTAS9261155 
GO:0005515protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007165signal transductionTAS9261155 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005886plasma membraneTAS9553137 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)-HPRD,BioGRID9614078 |11316748 
CRKL-v-crk sarcoma virus CT10 oncogene homolog (avian)-like-HPRD,BioGRID9614078 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID9553137 
HSP90AA1FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2heat shock protein 90kDa alpha (cytosolic), class A member 1Affinity Capture-MSBioGRID11912194 
HSPA4APG-2 | HS24/P52 | MGC131852 | RY | hsp70 | hsp70RYheat shock 70kDa protein 4Affinity Capture-MSBioGRID11912194 
NISCHFLJ14425 | FLJ40413 | FLJ90519 | I-1 | IRAS | KIAA0975nischarin-HPRD,BioGRID11912194 
PIK3CAMGC142161 | MGC142163 | PI3K | p110-alphaphosphoinositide-3-kinase, catalytic, alpha polypeptide-HPRD,BioGRID11912194 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD11912194 
PRKCZPKC-ZETA | PKC2protein kinase C, zeta-HPRD12774026 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11-HPRD12774026 
PTPN6HCP | HCPH | HPTP1C | PTP-1C | SH-PTP1 | SHP-1 | SHP-1L | SHP1protein tyrosine phosphatase, non-receptor type 6-HPRD12774026 
 


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