Gene Page: TMEM25
Summary ?
| GeneID | 84866 |
| Symbol | TMEM25 |
| Synonyms | - |
| Description | transmembrane protein 25 |
| Reference | MIM:613934|HGNC:HGNC:25890|Ensembl:ENSG00000149582|HPRD:11635|Vega:OTTHUMG00000166339 |
| Gene type | protein-coding |
| Map location | 11q23.3 |
| Pascal p-value | 0.011 |
| Sherlock p-value | 0.63 |
| eGene | Anterior cingulate cortex BA24 Cerebellar Hemisphere Cerebellum Cortex Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.006 |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs12289253 | 11 | 118405068 | TMEM25 | ENSG00000149582.11 | 5.068E-8 | 0 | 2995 | gtex_brain_ba24 |
| rs45505501 | 11 | 118405305 | TMEM25 | ENSG00000149582.11 | 5.947E-8 | 0 | 3232 | gtex_brain_ba24 |
| rs45485302 | 11 | 118405377 | TMEM25 | ENSG00000149582.11 | 6.006E-8 | 0 | 3304 | gtex_brain_ba24 |
| rs45548238 | 11 | 118405437 | TMEM25 | ENSG00000149582.11 | 9.845E-7 | 0 | 3364 | gtex_brain_ba24 |
| rs45522239 | 11 | 118405438 | TMEM25 | ENSG00000149582.11 | 5.96E-8 | 0 | 3365 | gtex_brain_ba24 |
| rs45474901 | 11 | 118405453 | TMEM25 | ENSG00000149582.11 | 4.148E-7 | 0 | 3380 | gtex_brain_ba24 |
| rs3741323 | 11 | 118405641 | TMEM25 | ENSG00000149582.11 | 5.024E-8 | 0 | 3568 | gtex_brain_ba24 |
| rs3741324 | 11 | 118405835 | TMEM25 | ENSG00000149582.11 | 5.024E-8 | 0 | 3762 | gtex_brain_ba24 |
| rs45576832 | 11 | 118406328 | TMEM25 | ENSG00000149582.11 | 1.756E-6 | 0 | 4255 | gtex_brain_ba24 |
| rs59533931 | 11 | 118407070 | TMEM25 | ENSG00000149582.11 | 4.895E-8 | 0 | 4997 | gtex_brain_ba24 |
| rs7108845 | 11 | 118407523 | TMEM25 | ENSG00000149582.11 | 5.024E-8 | 0 | 5450 | gtex_brain_ba24 |
| rs535207 | 11 | 118408033 | TMEM25 | ENSG00000149582.11 | 5.068E-8 | 0 | 5960 | gtex_brain_ba24 |
| rs75802917 | 11 | 118408339 | TMEM25 | ENSG00000149582.11 | 5.044E-8 | 0 | 6266 | gtex_brain_ba24 |
| rs73022038 | 11 | 118408471 | TMEM25 | ENSG00000149582.11 | 5.024E-8 | 0 | 6398 | gtex_brain_ba24 |
| rs74404016 | 11 | 118408653 | TMEM25 | ENSG00000149582.11 | 5.061E-8 | 0 | 6580 | gtex_brain_ba24 |
| rs73022041 | 11 | 118408789 | TMEM25 | ENSG00000149582.11 | 5.024E-8 | 0 | 6716 | gtex_brain_ba24 |
| rs73022042 | 11 | 118408893 | TMEM25 | ENSG00000149582.11 | 5.024E-8 | 0 | 6820 | gtex_brain_ba24 |
| rs7128587 | 11 | 118409302 | TMEM25 | ENSG00000149582.11 | 5.024E-8 | 0 | 7229 | gtex_brain_ba24 |
| rs7131631 | 11 | 118409374 | TMEM25 | ENSG00000149582.11 | 5.024E-8 | 0 | 7301 | gtex_brain_ba24 |
| rs11216880 | 11 | 118409536 | TMEM25 | ENSG00000149582.11 | 4.423E-8 | 0 | 7463 | gtex_brain_ba24 |
| rs11216881 | 11 | 118409539 | TMEM25 | ENSG00000149582.11 | 4.438E-8 | 0 | 7466 | gtex_brain_ba24 |
| rs7101585 | 11 | 118409583 | TMEM25 | ENSG00000149582.11 | 4.643E-8 | 0 | 7510 | gtex_brain_ba24 |
| rs11216883 | 11 | 118410468 | TMEM25 | ENSG00000149582.11 | 5.024E-8 | 0 | 8395 | gtex_brain_ba24 |
| rs11216884 | 11 | 118410488 | TMEM25 | ENSG00000149582.11 | 5.024E-8 | 0 | 8415 | gtex_brain_ba24 |
| rs11216885 | 11 | 118410545 | TMEM25 | ENSG00000149582.11 | 4.753E-8 | 0 | 8472 | gtex_brain_ba24 |
| rs11216886 | 11 | 118411424 | TMEM25 | ENSG00000149582.11 | 5.024E-8 | 0 | 9351 | gtex_brain_ba24 |
| rs7932700 | 11 | 118411713 | TMEM25 | ENSG00000149582.11 | 5.094E-8 | 0 | 9640 | gtex_brain_ba24 |
| rs60067274 | 11 | 118412296 | TMEM25 | ENSG00000149582.11 | 4.672E-8 | 0 | 10223 | gtex_brain_ba24 |
| rs61290697 | 11 | 118412358 | TMEM25 | ENSG00000149582.11 | 5.265E-8 | 0 | 10285 | gtex_brain_ba24 |
| rs58270621 | 11 | 118413604 | TMEM25 | ENSG00000149582.11 | 4.522E-7 | 0 | 11531 | gtex_brain_ba24 |
| rs3741320 | 11 | 118415847 | TMEM25 | ENSG00000149582.11 | 5.661E-8 | 0 | 13774 | gtex_brain_ba24 |
| rs3741319 | 11 | 118415848 | TMEM25 | ENSG00000149582.11 | 5.661E-8 | 0 | 13775 | gtex_brain_ba24 |
| rs3825055 | 11 | 118416073 | TMEM25 | ENSG00000149582.11 | 5.382E-7 | 0 | 14000 | gtex_brain_ba24 |
| rs2277295 | 11 | 118416253 | TMEM25 | ENSG00000149582.11 | 4.134E-7 | 0 | 14180 | gtex_brain_ba24 |
| rs143059106 | 11 | 118417645 | TMEM25 | ENSG00000149582.11 | 4.69E-7 | 0 | 15572 | gtex_brain_ba24 |
| rs45536433 | 11 | 118417648 | TMEM25 | ENSG00000149582.11 | 7.969E-7 | 0 | 15575 | gtex_brain_ba24 |
| rs59176377 | 11 | 118419295 | TMEM25 | ENSG00000149582.11 | 9.551E-7 | 0 | 17222 | gtex_brain_ba24 |
| rs113739713 | 11 | 118420101 | TMEM25 | ENSG00000149582.11 | 4.364E-7 | 0 | 18028 | gtex_brain_ba24 |
| rs11216887 | 11 | 118420736 | TMEM25 | ENSG00000149582.11 | 4.556E-7 | 0 | 18663 | gtex_brain_ba24 |
| rs11216890 | 11 | 118421569 | TMEM25 | ENSG00000149582.11 | 2.429E-6 | 0 | 19496 | gtex_brain_ba24 |
| rs11216891 | 11 | 118422234 | TMEM25 | ENSG00000149582.11 | 1.756E-6 | 0 | 20161 | gtex_brain_ba24 |
| rs2277293 | 11 | 118422868 | TMEM25 | ENSG00000149582.11 | 4.337E-7 | 0 | 20795 | gtex_brain_ba24 |
| rs11216892 | 11 | 118424008 | TMEM25 | ENSG00000149582.11 | 4.377E-7 | 0 | 21935 | gtex_brain_ba24 |
| rs56403966 | 11 | 118425051 | TMEM25 | ENSG00000149582.11 | 2.214E-6 | 0 | 22978 | gtex_brain_ba24 |
| rs55857590 | 11 | 118425063 | TMEM25 | ENSG00000149582.11 | 4.351E-7 | 0 | 22990 | gtex_brain_ba24 |
| rs2277292 | 11 | 118425419 | TMEM25 | ENSG00000149582.11 | 4.692E-7 | 0 | 23346 | gtex_brain_ba24 |
| rs7929887 | 11 | 118428791 | TMEM25 | ENSG00000149582.11 | 4.478E-7 | 0 | 26718 | gtex_brain_ba24 |
| rs201228166 | 11 | 118428828 | TMEM25 | ENSG00000149582.11 | 4.722E-7 | 0 | 26755 | gtex_brain_ba24 |
| rs111942423 | 11 | 118429764 | TMEM25 | ENSG00000149582.11 | 4.478E-7 | 0 | 27691 | gtex_brain_ba24 |
| rs11216896 | 11 | 118430048 | TMEM25 | ENSG00000149582.11 | 4.478E-7 | 0 | 27975 | gtex_brain_ba24 |
| rs11552421 | 11 | 118430519 | TMEM25 | ENSG00000149582.11 | 4.286E-7 | 0 | 28446 | gtex_brain_ba24 |
| rs56693362 | 11 | 118430773 | TMEM25 | ENSG00000149582.11 | 1.038E-6 | 0 | 28700 | gtex_brain_ba24 |
| rs11216897 | 11 | 118432279 | TMEM25 | ENSG00000149582.11 | 1.629E-7 | 0 | 30206 | gtex_brain_ba24 |
| rs4326835 | 11 | 118432404 | TMEM25 | ENSG00000149582.11 | 1.032E-6 | 0 | 30331 | gtex_brain_ba24 |
| rs11216898 | 11 | 118432852 | TMEM25 | ENSG00000149582.11 | 1.379E-7 | 0 | 30779 | gtex_brain_ba24 |
| rs200984057 | 11 | 118433259 | TMEM25 | ENSG00000149582.11 | 3.372E-8 | 0 | 31186 | gtex_brain_ba24 |
| rs59108310 | 11 | 118433729 | TMEM25 | ENSG00000149582.11 | 3.349E-8 | 0 | 31656 | gtex_brain_ba24 |
| rs11216899 | 11 | 118434421 | TMEM25 | ENSG00000149582.11 | 1.954E-7 | 0 | 32348 | gtex_brain_ba24 |
| rs60753148 | 11 | 118434835 | TMEM25 | ENSG00000149582.11 | 1.894E-7 | 0 | 32762 | gtex_brain_ba24 |
| rs2277291 | 11 | 118435756 | TMEM25 | ENSG00000149582.11 | 7.251E-7 | 0 | 33683 | gtex_brain_ba24 |
| rs11216900 | 11 | 118436079 | TMEM25 | ENSG00000149582.11 | 3.502E-8 | 0 | 34006 | gtex_brain_ba24 |
| rs11216902 | 11 | 118437279 | TMEM25 | ENSG00000149582.11 | 3.377E-8 | 0 | 35206 | gtex_brain_ba24 |
| rs60837962 | 11 | 118438448 | TMEM25 | ENSG00000149582.11 | 6.631E-7 | 0 | 36375 | gtex_brain_ba24 |
| rs12224844 | 11 | 118439048 | TMEM25 | ENSG00000149582.11 | 3.323E-8 | 0 | 36975 | gtex_brain_ba24 |
| rs11216904 | 11 | 118440863 | TMEM25 | ENSG00000149582.11 | 3.317E-8 | 0 | 38790 | gtex_brain_ba24 |
| rs10892243 | 11 | 118441846 | TMEM25 | ENSG00000149582.11 | 3.314E-8 | 0 | 39773 | gtex_brain_ba24 |
| rs11216905 | 11 | 118442577 | TMEM25 | ENSG00000149582.11 | 1.613E-7 | 0 | 40504 | gtex_brain_ba24 |
| rs11216906 | 11 | 118443944 | TMEM25 | ENSG00000149582.11 | 3.314E-8 | 0 | 41871 | gtex_brain_ba24 |
| rs11216907 | 11 | 118444525 | TMEM25 | ENSG00000149582.11 | 1.773E-7 | 0 | 42452 | gtex_brain_ba24 |
| rs17122269 | 11 | 118445275 | TMEM25 | ENSG00000149582.11 | 7.251E-7 | 0 | 43202 | gtex_brain_ba24 |
| rs73023341 | 11 | 118445585 | TMEM25 | ENSG00000149582.11 | 3.314E-8 | 0 | 43512 | gtex_brain_ba24 |
| rs55844025 | 11 | 118446298 | TMEM25 | ENSG00000149582.11 | 3.302E-7 | 0 | 44225 | gtex_brain_ba24 |
| rs9736327 | 11 | 118447580 | TMEM25 | ENSG00000149582.11 | 3.314E-8 | 0 | 45507 | gtex_brain_ba24 |
| rs9735421 | 11 | 118447597 | TMEM25 | ENSG00000149582.11 | 3.314E-8 | 0 | 45524 | gtex_brain_ba24 |
| rs9735449 | 11 | 118448087 | TMEM25 | ENSG00000149582.11 | 3.823E-7 | 0 | 46014 | gtex_brain_ba24 |
| rs17122278 | 11 | 118449370 | TMEM25 | ENSG00000149582.11 | 5.959E-7 | 0 | 47297 | gtex_brain_ba24 |
| rs73023350 | 11 | 118449396 | TMEM25 | ENSG00000149582.11 | 3.317E-8 | 0 | 47323 | gtex_brain_ba24 |
| rs11216909 | 11 | 118449746 | TMEM25 | ENSG00000149582.11 | 3.283E-9 | 0 | 47673 | gtex_brain_ba24 |
| rs11216910 | 11 | 118450046 | TMEM25 | ENSG00000149582.11 | 3.314E-8 | 0 | 47973 | gtex_brain_ba24 |
| rs7122547 | 11 | 118450260 | TMEM25 | ENSG00000149582.11 | 1.215E-7 | 0 | 48187 | gtex_brain_ba24 |
| rs7126175 | 11 | 118450875 | TMEM25 | ENSG00000149582.11 | 3.314E-8 | 0 | 48802 | gtex_brain_ba24 |
| rs11216911 | 11 | 118451901 | TMEM25 | ENSG00000149582.11 | 3.314E-8 | 0 | 49828 | gtex_brain_ba24 |
| rs11216912 | 11 | 118452334 | TMEM25 | ENSG00000149582.11 | 3.314E-8 | 0 | 50261 | gtex_brain_ba24 |
| rs60112336 | 11 | 118453483 | TMEM25 | ENSG00000149582.11 | 3.841E-7 | 0 | 51410 | gtex_brain_ba24 |
| rs11216913 | 11 | 118453681 | TMEM25 | ENSG00000149582.11 | 3.314E-8 | 0 | 51608 | gtex_brain_ba24 |
| rs17842763 | 11 | 118454177 | TMEM25 | ENSG00000149582.11 | 3.314E-8 | 0 | 52104 | gtex_brain_ba24 |
| rs11216914 | 11 | 118456414 | TMEM25 | ENSG00000149582.11 | 9.198E-8 | 0 | 54341 | gtex_brain_ba24 |
| rs17092756 | 11 | 118457630 | TMEM25 | ENSG00000149582.11 | 3.314E-8 | 0 | 55557 | gtex_brain_ba24 |
| rs57438673 | 11 | 118459039 | TMEM25 | ENSG00000149582.11 | 1.773E-7 | 0 | 56966 | gtex_brain_ba24 |
| rs113054880 | 11 | 118459702 | TMEM25 | ENSG00000149582.11 | 1.584E-7 | 0 | 57629 | gtex_brain_ba24 |
| rs11216916 | 11 | 118461605 | TMEM25 | ENSG00000149582.11 | 3.314E-8 | 0 | 59532 | gtex_brain_ba24 |
| rs11216917 | 11 | 118462160 | TMEM25 | ENSG00000149582.11 | 3.314E-8 | 0 | 60087 | gtex_brain_ba24 |
| rs11216921 | 11 | 118464815 | TMEM25 | ENSG00000149582.11 | 1.945E-7 | 0 | 62742 | gtex_brain_ba24 |
| rs11216922 | 11 | 118465295 | TMEM25 | ENSG00000149582.11 | 3.541E-8 | 0 | 63222 | gtex_brain_ba24 |
| rs11216923 | 11 | 118465501 | TMEM25 | ENSG00000149582.11 | 3.541E-8 | 0 | 63428 | gtex_brain_ba24 |
| rs7115634 | 11 | 118466249 | TMEM25 | ENSG00000149582.11 | 4.489E-7 | 0 | 64176 | gtex_brain_ba24 |
| rs7931564 | 11 | 118469571 | TMEM25 | ENSG00000149582.11 | 3.314E-8 | 0 | 67498 | gtex_brain_ba24 |
| rs11216924 | 11 | 118470092 | TMEM25 | ENSG00000149582.11 | 4.489E-7 | 0 | 68019 | gtex_brain_ba24 |
| rs11216925 | 11 | 118471423 | TMEM25 | ENSG00000149582.11 | 3.314E-8 | 0 | 69350 | gtex_brain_ba24 |
| rs11216926 | 11 | 118471996 | TMEM25 | ENSG00000149582.11 | 4.489E-7 | 0 | 69923 | gtex_brain_ba24 |
| rs10892245 | 11 | 118472354 | TMEM25 | ENSG00000149582.11 | 3.314E-8 | 0 | 70281 | gtex_brain_ba24 |
| rs1047079 | 11 | 118473231 | TMEM25 | ENSG00000149582.11 | 7.251E-7 | 0 | 71158 | gtex_brain_ba24 |
| rs17742 | 11 | 118473385 | TMEM25 | ENSG00000149582.11 | 3.314E-8 | 0 | 71312 | gtex_brain_ba24 |
| rs375152863 | 11 | 118474719 | TMEM25 | ENSG00000149582.11 | 3.568E-6 | 0 | 72646 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005576 | extracellular region | IEA | - | |
| GO:0016021 | integral to membrane | IEA | - | |
| GO:0005886 | plasma membrane | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA ANAPLASTIC DN | 537 | 339 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | All SZGR 2.0 genes in this pathway |
| LIEN BREAST CARCINOMA METAPLASTIC VS DUCTAL DN | 114 | 58 | All SZGR 2.0 genes in this pathway |
| VANASSE BCL2 TARGETS DN | 74 | 50 | All SZGR 2.0 genes in this pathway |
| IVANOVSKA MIR106B TARGETS | 90 | 56 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 NOT SATB1 DN | 448 | 282 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
| miRNA family | Target position | miRNA ID | miRNA seq | ||
|---|---|---|---|---|---|
| UTR start | UTR end | Match method | |||
| miR-103/107 | 568 | 574 | 1A | hsa-miR-103brain | AGCAGCAUUGUACAGGGCUAUGA |
| hsa-miR-107brain | AGCAGCAUUGUACAGGGCUAUCA | ||||
| miR-128 | 882 | 889 | 1A,m8 | hsa-miR-128a | UCACAGUGAACCGGUCUCUUUU |
| hsa-miR-128b | UCACAGUGAACCGGUCUCUUUC | ||||
| miR-218 | 550 | 557 | 1A,m8 | hsa-miR-218brain | UUGUGCUUGAUCUAACCAUGU |
| hsa-miR-218brain | UUGUGCUUGAUCUAACCAUGU | ||||
| hsa-miR-218brain | UUGUGCUUGAUCUAACCAUGU | ||||
| miR-27 | 883 | 889 | m8 | hsa-miR-27abrain | UUCACAGUGGCUAAGUUCCGC |
| hsa-miR-27bbrain | UUCACAGUGGCUAAGUUCUGC | ||||
| miR-320 | 1042 | 1048 | 1A | hsa-miR-320 | AAAAGCUGGGUUGAGAGGGCGAA |
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.