Gene Page: AJUBA

Summary ?
GeneID84962
SymbolAJUBA
SynonymsJUB
Descriptionajuba LIM protein
ReferenceMIM:609066|HGNC:HGNC:20250|Ensembl:ENSG00000129474|HPRD:16426|Vega:OTTHUMG00000028711
Gene typeprotein-coding
Map location14q11.2
Pascal p-value0.002
Fetal beta1.57

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DNM:Guipponi_2014Whole Exome Sequencing analysis49 DNMs were identified by comparing the exome of 53 individuals with sporadic SCZ and of their non-affected parents

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
AJUBATGNM_032876p.L284LsynonymousNANASchizophreniaDNM:Guipponi_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0005215transporter activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007155cell adhesionIEA-
GO:0007049cell cycleIEA-
GO:0048041focal adhesion formationIEA-
GO:0006810transportIEA-
GO:0043087regulation of GTPase activityIEA-
GO:0030334regulation of cell migrationIEA-
GO:0035313wound healing, spreading of epidermal cellsIEA-
GO:0030032lamellipodium biogenesisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005813centrosomeIEA-
GO:0005856cytoskeletonIEA-
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
GO:0030027lamellipodiumIEA-
GO:0005925focal adhesionIEA-
GO:0005886plasma membraneIEA-
GO:0030054cell junctionIEA-

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-148/152101510221A,m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-17-5p/20/93.mr/106/519.d15071513m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-182135413611A,m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-24101910261A,m8hsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-5398548601Ahsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
miR-91411471Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA