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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: SHANK3

Summary

GeneID

85358

Symbol

SHANK3

Synonyms

KIAA1650|PROSAP2|PSAP2|SPANK-2

Description

SH3 and multiple ankyrin repeat domains 3

Locus tag

Gene type

protein-coding

Map location

22q13.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005515

protein binding

IEA

GO:0017124

SH3 domain binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000165

MAPKKK cascade

IEA

GO:0001838

embryonic epithelial tube formation

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0045211

postsynaptic membrane

IEA

Synap, Neurotransmitter (GO term level: 5)

GO:0045202

synapse

IEA

neuron, Synap, Neurotransmitter, Glial (GO term level: 2)

GO:0005737

cytoplasm

IEA

GO:0005886

plasma membrane

IEA

GO:0030054

cell junction

IEA

Interactions

Shown by Network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ARHGEF7	BETA-PIX \| COOL1 \| DKFZp686C12170 \| DKFZp761K1021 \| KIAA0142 \| KIAA0412 \| Nbla10314 \| P50 \| P50BP \| P85 \| P85COOL1 \| P85SPR \| PAK3 \| PIXB	Rho guanine nucleotide exchange factor (GEF) 7	Affinity Capture-Western Two-hybrid	BioGRID	12626503
DLGAP1	DAP-1 \| DAP-1-ALPHA \| DAP-1-BETA \| GKAP \| MGC88156 \| SAPAP1 \| hGKAP	discs, large (Drosophila) homolog-associated protein 1	Two-hybrid	BioGRID	10527873
DLGAP2	DAP2 \| SAPAP2	discs, large (Drosophila) homolog-associated protein 2	Two-hybrid	BioGRID	10527873
DLGAP3	DAP3 \| SAPAP3	discs, large (Drosophila) homolog-associated protein 3	Two-hybrid	BioGRID	10527873
DLGAP4	DAP4 \| KIAA0964 \| MGC131862 \| RP5-977B1.6 \| SAPAP4	discs, large (Drosophila) homolog-associated protein 4	Two-hybrid	BioGRID	10527873
SPTAN1	(ALPHA)II-SPECTRIN \| FLJ44613 \| NEAS	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	Two-hybrid	BioGRID	11509555

Pathway annotation

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-10	1712	1718	m8	hsa-miR-10a	UACCCUGUAGAUCCGAAUUUGUG
miR-10	1712	1718	m8	hsa-miR-10b	UACCCUGUAGAACCGAAUUUGU
miR-128	1330	1337	1A,m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	1330	1337	1A,m8	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-214	719	725	m8	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
miR-27	1331	1337	m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	1331	1337	m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-299-3p	1644	1650	1A	hsa-miR-299-3p	UAUGUGGGAUGGUAAACCGCUU
miR-331	1506	1512	m8	hsa-miR-331^brain	GCCCCUGGGCCUAUCCUAGAA
miR-34/449	543	550	1A,m8	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
				hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
				hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-369-3p	1861	1867	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	1861	1868	1A,m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-375	449	455	1A	hsa-miR-375	UUUGUUCGUUCGGCUCGCGUGA
miR-376c	1826	1832	m8	hsa-miR-376c	AACAUAGAGGAAAUUCCACG
miR-378	331	337	m8	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-491	1815	1821	1A	hsa-miR-491^brain	AGUGGGGAACCCUUCCAUGAGGA
miR-494	1829	1835	m8	hsa-miR-494^brain	UGAAACAUACACGGGAAACCUCUU
miR-504	1713	1720	1A,m8	hsa-miR-504	AGACCCUGGUCUGCACUCUAU
miR-543	106	112	m8	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-7	523	530	1A,m8	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.