Gene Page: CASK

Summary
GeneID  8573
Symbol  CASK
Synonyms  CAGH39|CMG|FLJ22219|FLJ31914|LIN2|MICPCH|TNRC8
Description  calcium/calmodulin-dependent serine protein kinase (MAGUK family)
See related  HGNC:1497|MIM:300172|Ensembl:ENSG00000147044|HPRD:02164|
Locus tag  RP11-540L11.1
Gene type  protein-coding
Map location  Xp11.4
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.461 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1861 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
KIAA13050.970.95
PLXNB20.970.97
PLEKHG20.970.92
PLXNA30.970.93
KDM6B0.950.93
GTF2IRD10.950.89
CELSR30.940.84
AD000671.10.940.89
CASP20.940.85
ZNF6460.940.89
Top 10 negatively co-expressed genes
C5orf53-0.69-0.81
FBXO2-0.67-0.65
HLA-F-0.67-0.69
ACOT13-0.66-0.77
ALDOC-0.66-0.64
ACYP2-0.65-0.73
S100B-0.65-0.77
AIFM3-0.65-0.63
CA4-0.65-0.76
LDHD-0.65-0.61
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIEA-
GO:0005516calmodulin bindingIEA-
GO:0005524ATP bindingIEA-
GO:0004385guanylate kinase activityTAS9660868 
GO:0004674protein serine/threonine kinase activityIEA-
GO:0016740transferase activityIEA-
GO:0016301kinase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007155cell adhesionTAS9660868 
GO:0006468protein amino acid phosphorylationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
GO:0005886plasma membraneTAS9660868 
GO:0015629actin cytoskeletonTAS9660868 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APBA1D9S411E | MINT1 | X11 | X11A | X11ALPHAamyloid beta (A4) precursor protein-binding, family A, member 1X11-ALPHA interacts with Lin-2.BIND9822620 
-HPRD,BioGRID9753324 |9822620 
|9952408|9822620 |9952408 
ATP2B4ATP2B2 | DKFZp686G08106 | DKFZp686M088 | MXRA1 | PMCA4 | PMCA4b | PMCA4xATPase, Ca++ transporting, plasma membrane 4-HPRD,BioGRID12511555 
C16orf70C16orf6 | FLJ12076 | LIN10 | lin-10chromosome 16 open reading frame 70Reconstituted ComplexBioGRID9822620 
CACNA1BBIII | CACNL1A5 | CACNN | Cav2.2calcium channel, voltage-dependent, N type, alpha 1B subunitThe SH3 domain of CASK interacts with the carboxy-terminal proline-rich region (PRR) of Ca-alpha-1B.BIND10455105 
CADM1BL2 | DKFZp686F1789 | IGSF4 | IGSF4A | MGC149785 | MGC51880 | NECL2 | Necl-2 | RA175 | ST17 | SYNCAM | TSLC1 | sTSLC-1 | sgIGSF | synCAM1cell adhesion molecule 1-HPRD,BioGRID12202822 
CASKIN1ANKS5ACASK interacting protein 1-HPRD12040031 
CD2APCMS | DKFZp586H0519CD2-associated proteinReconstituted ComplexBioGRID15331416 
CNTNAP2AUTS15 | CASPR2 | CDFE | DKFZp781D1846 | NRXN4contactin associated protein-like 2-HPRD,BioGRID12093160 
CNTNAP4CASPR4 | KIAA1763contactin associated protein-like 4-HPRD,BioGRID12093160 
DFNB31CIP98 | DKFZp434N014 | KIAA1526 | RP11-9M16.1 | USH2D | WHRN | WIdeafness, autosomal recessive 31-HPRD,BioGRID12641734 
DLG1DKFZp761P0818 | DKFZp781B0426 | DLGH1 | SAP97 | dJ1061C18.1.1 | hdlgdiscs, large homolog 1 (Drosophila)Affinity Capture-Western
in vitro
in vivo
Reconstituted Complex
Two-hybrid		BioGRID10993877 |12151521 
|12351654 |14960569 
CASK interacts with DLG1 (SAP97).BIND15729360 
-HPRD10993877 |12351654 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)-HPRD,BioGRID12151521 
EPB414.1R | EL1 | HEerythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)-HPRD,BioGRID9660868 
F11RCD321 | JAM | JAM-1 | JAM-A | JAM1 | JAMA | JCAM | KAT | PAM-1F11 receptor-HPRD,BioGRID11120739 
FCHSD2KIAA0769 | NWK | SH3MD3FCH and double SH3 domains 2-HPRD,BioGRID14627983 
GRIK2EAA4 | GLR6 | GLUK6 | GLUR6 | MGC74427 | MRT6glutamate receptor, ionotropic, kainate 2-HPRD12151522 
ID1ID | bHLHb24inhibitor of DNA binding 1, dominant negative helix-loop-helix proteinCASK interacts with Id1.BIND15694377 
CASK interacts with Id1'.BIND15694377 
Reconstituted Complex
Two-hybrid		BioGRID15694377 
KCNJ12FLJ14167 | IRK2 | KCNJN1 | Kir2.2 | Kir2.2v | hIRK | hIRK1 | hkir2.2x | kcnj12xpotassium inwardly-rectifying channel, subfamily J, member 12-HPRD,BioGRID14960569 |15024025 
KCNJ4HIR | HIRK2 | HRK1 | IRK3 | Kir2.3 | MGC142066 | MGC142068potassium inwardly-rectifying channel, subfamily J, member 4-HPRD11742811 
Affinity Capture-WesternBioGRID14960569 |15024025 
LIN7ALIN-7A | LIN7 | MALS-1 | MGC148143 | TIP-33 | VELI1lin-7 homolog A (C. elegans)Affinity Capture-Western
in vitro
in vivo
Reconstituted Complex		BioGRID9753324 |9822620 
|14960569 
-HPRD9753324|9822620 |9952408 
LIN7BLIN-7B | MALS-2 | MALS2 | VELI2lin-7 homolog B (C. elegans)-HPRD11742811 
Affinity Capture-WesternBioGRID14960569 
LIN7CFLJ11215 | LIN-7-C | LIN-7C | MALS-3 | MALS3 | VELI3lin-7 homolog C (C. elegans)Affinity Capture-WesternBioGRID14960569 
NPHS1CNF | NPHNnephrosis 1, congenital, Finnish type (nephrin)Affinity Capture-MS
Reconstituted Complex		BioGRID15331416 
NRXN1DKFZp313P2036 | FLJ35941 | Hs.22998 | KIAA0578neurexin 1-HPRD,BioGRID11036064 
-HPRD8786425 
NRXN2FLJ40892 | KIAA0921neurexin 2-HPRD8786425 
NRXN3KIAA0743 | MGC176711neurexin 3-HPRD,BioGRID8786425 
PARK2AR-JP | LPRS2 | PDJ | PRKNParkinson disease (autosomal recessive, juvenile) 2, parkin-HPRD,BioGRID11679592 
RAB3A-RAB3A, member RAS oncogene family-HPRD11377421 
RPH3AKIAA0985rabphilin 3A homolog (mouse)-HPRD,BioGRID11377421 
SDC1CD138 | SDC | SYND1 | syndecansyndecan 1-HPRD,BioGRID9660868 
SDC2HSPG | HSPG1 | SYND2syndecan 2-HPRD,BioGRID9660868 
SDC3N-syndecan | SDCN | SYND3syndecan 3-HPRD10460248 
TANC1KIAA1728 | ROLSB | TANCtetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1-HPRD15673434 
TBR1MGC141978 | TES-56T-box, brain, 1-HPRD,BioGRID10749215 
TSPYL2CDA1 | CINAP | CTCL | DENTT | HRIHFB2216 | SE20-4TSPY-like 2Affinity Capture-Western
Two-hybrid		BioGRID15066269 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_TIGHT_JUNCTION 13486All SZGR genes in this pathway
PID_SYNDECAN_1_PATHWAY 4629All SZGR genes in this pathway
PID_SYNDECAN_2_PATHWAY 3327All SZGR genes in this pathway
PID_SYNDECAN_3_PATHWAY 1715All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_UP 294178All SZGR genes in this pathway
WANG_LMO4_TARGETS_DN 352225All SZGR genes in this pathway
WANG_CLIM2_TARGETS_UP 269146All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_UP 162116All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_GRADES_1_2_UP 13784All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_SKIN_UP 177113All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_UP 12672All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_UP 12073All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN 394258All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
MANALO_HYPOXIA_UP 207145All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_CD1_AND_CD2_UP 8951All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_RESPONSE 3528All SZGR genes in this pathway
ULE_SPLICING_VIA_NOVA2 4338All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_14HR_UP 156101All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_10HR_UP 10169All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_UP 280183All SZGR genes in this pathway
RIGGINS_TAMOXIFEN_RESISTANCE_DN 220147All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_D_DN 7834All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
SYED_ESTRADIOL_RESPONSE 1915All SZGR genes in this pathway
PYEON_CANCER_HEAD_AND_NECK_VS_CERVICAL_UP 19395All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_30MIN_UP 5638All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_UP 5541All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL 177132All SZGR genes in this pathway
CHYLA_CBFA2T3_TARGETS_UP 387225All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-146207213m8hsa-miR-146aUGAGAACUGAAUUCCAUGGGUU
hsa-miR-146bbrainUGAGAACUGAAUUCCAUAGGCU
miR-196981051A,m8hsa-miR-196aUAGGUAGUUUCAUGUUGUUGG
hsa-miR-196bUAGGUAGUUUCCUGUUGUUGG
miR-369-3p247253m8hsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-3707682m8hsa-miR-370brainGCCUGCUGGGGUGGAACCUGG
miR-410269275m8hsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-49557631Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-5432652721A,m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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