Gene Page

Home
Datasets
Search
Analysis & Tools
Documents
About SZGR
Quick search: (e.g. 207 or AKT)

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

Release Site Map Support Contact us

Gene Page: DYNLL1

Summary

GeneID

8655

Symbol

DYNLL1

Synonyms

DLC1|DLC8|DNCL1|DNCLC1|LC8|LC8a|MGC126137|MGC126138|PIN|hdlc1

Description

dynein, light chain, LC8-type 1

Locus tag

Gene type

protein-coding

Map location

12q24.23

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.2404

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

TRIP4

0.90

0.89

WDR70

0.90

0.88

GART

0.90

0.87

ELP2

0.89

0.87

WTAP

0.89

0.87

KDM1

0.89

0.84

CDKN2AIP

0.89

0.87

METAP2

0.89

0.87

CNOT2

0.89

0.84

ZFP112

0.89

0.83

Top 10 negatively co-expressed genes

AF347015.27

-0.74

-0.84

MT-CO2

-0.73

-0.83

AF347015.33

-0.72

-0.82

AF347015.31

-0.72

-0.83

MT-CYB

-0.72

-0.83

AF347015.15

-0.72

-0.86

AF347015.8

-0.72

-0.84

HLA-F

-0.70

-0.74

TINAGL1

-0.70

-0.76

AF347015.2

-0.69

-0.83

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003777

microtubule motor activity

IEA

GO:0005515

protein binding

IPI

14607844 |18579519

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007292

female gamete generation

TAS

8628263

GO:0008633

activation of pro-apoptotic gene products

EXP

14764673

GO:0009653

anatomical structure morphogenesis

TAS

8628263

GO:0007017

microtubule-based process

IEA

GO:0042326

negative regulation of phosphorylation

IDA

18579519

GO:0030036

actin cytoskeleton organization

TAS

8628263

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005829

cytosol

EXP

12591950

GO:0005868

cytoplasmic dynein complex

TAS

8628263

GO:0005874

microtubule

IEA

GO:0005737

cytoplasm

IDA

8628263

GO:0005886

plasma membrane

EXP

12591950

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTB	PS1TP5BP1	actin, beta	-	HPRD	14760703
ACTC1	ACTC \| CMD1R \| CMH11	actin, alpha, cardiac muscle 1	-	HPRD	14760703
ACTG1	ACT \| ACTG \| DFNA20 \| DFNA26	actin, gamma 1	-	HPRD	14760703
ALDOA	ALDA \| MGC10942 \| MGC17716 \| MGC17767	aldolase A, fructose-bisphosphate	-	HPRD	14760703
ASF1B	CIA-II \| FLJ10604	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	Affinity Capture-MS	BioGRID	17353931
BCAS1	AIBC1 \| NABC1	breast carcinoma amplified sequence 1	DLC8 interacts with AIBC1. This interaction was modeled on a demonstrated interaction between DLC8 from an unspecified species and human AIBC1.	BIND	11148209
BCAS1	AIBC1 \| NABC1	breast carcinoma amplified sequence 1	Affinity Capture-MS	BioGRID	17353931
BCL2	Bcl-2	B-cell CLL/lymphoma 2	Affinity Capture-Western	BioGRID	10198631
BCL2L1	BCL-XL/S \| BCL2L \| BCLX \| Bcl-X \| DKFZp781P2092 \| bcl-xL \| bcl-xS	BCL2-like 1	Affinity Capture-Western	BioGRID	10198631
BCL2L11	BAM \| BIM \| BIM-alpha6 \| BIM-beta6 \| BIM-beta7 \| BOD \| BimEL \| BimL	BCL2-like 11 (apoptosis facilitator)	-	HPRD	10198631
BCL2L11		BCL2-like 11 (apoptosis facilitator)	Reconstituted Complex	BioGRID	14561217 \|15193260
BMF	FLJ00065	Bcl2 modifying factor	Reconstituted Complex	BioGRID	14561217
C14orf1	ERG28 \| NET51	chromosome 14 open reading frame 1	Two-hybrid	BioGRID	16169070
CA2	CA-II \| CAII \| Car2	carbonic anhydrase II	-	HPRD	14760703
CACNB1	CAB1 \| CACNLB1 \| CCHLB1 \| MGC41896	calcium channel, voltage-dependent, beta 1 subunit	-	HPRD	14760703
CS	-	citrate synthase	-	HPRD	14760703
DDX3X	DBX \| DDX14 \| DDX3 \| HLP2	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	Affinity Capture-MS	BioGRID	17353931
DLG2	DKFZp781D1854 \| DKFZp781E0954 \| FLJ37266 \| MGC131811 \| PSD-93	discs, large homolog 2, chapsyn-110 (Drosophila)	Affinity Capture-Western	BioGRID	10844022
DLG4	FLJ97752 \| FLJ98574 \| PSD95 \| SAP90	discs, large homolog 4 (Drosophila)	Affinity Capture-Western Reconstituted Complex	BioGRID	10844022
DLG4	FLJ97752 \| FLJ98574 \| PSD95 \| SAP90	discs, large homolog 4 (Drosophila)	-	HPRD	14760703
DLGAP1	DAP-1 \| DAP-1-ALPHA \| DAP-1-BETA \| GKAP \| MGC88156 \| SAPAP1 \| hGKAP	discs, large (Drosophila) homolog-associated protein 1	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10844022
			DAP-1 interacts with DLC-1.	BIND	11122378
			DLC8 interacts with GKAP. This interaction was modeled on a demonstrated interaction between DLC8 from an unspecified species and human GKAP.	BIND	11148209
DNAJB9	DKFZp564F1862 \| ERdj4 \| MDG1 \| MST049 \| MSTP049	DnaJ (Hsp40) homolog, subfamily B, member 9	Two-hybrid	BioGRID	16169070
DNM2	CMTDI1 \| CMTDIB \| DI-CMTB \| DYN2 \| DYNII	dynamin 2	-	HPRD	14760703
DNM3	KIAA0820 \| MGC70433	dynamin 3	-	HPRD	14760703
DNMT1	AIM \| CXXC9 \| DNMT \| FLJ16293 \| MCMT \| MGC104992	DNA (cytosine-5-)-methyltransferase 1	-	HPRD	14760703
DYNC1H1	DHC1 \| DHC1a \| DKFZp686P2245 \| DNCH1 \| DNCL \| DNECL \| DYHC \| Dnchc1 \| HL-3 \| KIAA0325 \| p22	dynein, cytoplasmic 1, heavy chain 1	-	HPRD	14760703
DYNC1I1	DNCI1 \| DNCIC1	dynein, cytoplasmic 1, intermediate chain 1	Two-hybrid	BioGRID	12475239
DYNC1I2	DNCI2 \| FLJ21089 \| FLJ90842 \| IC2 \| MGC104199 \| MGC111094 \| MGC9324	dynein, cytoplasmic 1, intermediate chain 2	Affinity Capture-MS	BioGRID	17353931
DYNLL1	DLC1 \| DLC8 \| DNCL1 \| DNCLC1 \| LC8 \| LC8a \| MGC126137 \| MGC126138 \| PIN \| hdlc1	dynein, light chain, LC8-type 1	LC8 interacts with itself to form a homodimer.	BIND	15117959
DYNLL1		dynein, light chain, LC8-type 1	Two-hybrid	BioGRID	12475239 \|16169070
EEF1A1	CCS-3 \| CCS3 \| EEF-1 \| EEF1A \| EF-Tu \| EF1A \| FLJ25721 \| GRAF-1EF \| HNGC:16303 \| LENG7 \| MGC102687 \| MGC131894 \| MGC16224 \| PTI1 \| eEF1A-1	eukaryotic translation elongation factor 1 alpha 1	Two-hybrid	BioGRID	16169070
GAPDH	G3PD \| GAPD \| MGC88685	glyceraldehyde-3-phosphate dehydrogenase	-	HPRD	14760703
GLUD1	GDH \| GDH1 \| GLUD \| MGC132003	glutamate dehydrogenase 1	-	HPRD	14760703
GLUL	GLNS \| GS \| PIG43 \| PIG59	glutamate-ammonia ligase (glutamine synthetase)	-	HPRD	14760703
GPHN	GEPH \| GPH \| GPHRYN \| KIAA1385	gephyrin	-	HPRD	12097491 \|14760703
HIP1R	FLJ14000 \| FLJ27022 \| HIP12 \| HIP3 \| ILWEQ \| KIAA0655 \| MGC47513	huntingtin interacting protein 1 related	-	HPRD	14760703
LDHA	LDH-M \| LDH1 \| PIG19	lactate dehydrogenase A	-	HPRD	14760703
MAP1B	DKFZp686E1099 \| DKFZp686F1345 \| FLJ38954 \| FUTSCH \| MAP5	microtubule-associated protein 1B	-	HPRD	14760703
MARK3	CTAK1 \| KP78 \| PAR1A	MAP/microtubule affinity-regulating kinase 3	-	HPRD	14760703
MAST2	FLJ39200 \| KIAA0807 \| MAST205 \| MTSSK \| RP4-533D7.1	microtubule associated serine/threonine kinase 2	-	HPRD	14760703
ME2	-	malic enzyme 2, NAD(+)-dependent, mitochondrial	-	HPRD	14760703
MTA1	-	metastasis associated 1	-	HPRD	14760703
MTR	FLJ33168 \| FLJ43216 \| FLJ45386 \| MS	5-methyltetrahydrofolate-homocysteine methyltransferase	-	HPRD	14760703
MYO10	FLJ10639 \| FLJ21066 \| FLJ22268 \| FLJ43256 \| KIAA0799 \| MGC131988	myosin X	-	HPRD	14760703
MYO5A	GS1 \| MYH12 \| MYO5 \| MYR12	myosin VA (heavy chain 12, myoxin)	-	HPRD,BioGRID	10844022
MYO5A	GS1 \| MYH12 \| MYO5 \| MYR12	myosin VA (heavy chain 12, myoxin)	DLC8 interacts with Myosin V. This interaction was modeled on a demonstrated interaction between DLC8 from an unspecified species and human Myosin V.	BIND	11148209
NDUFA4L2	FLJ26118 \| NUOMS	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2	Two-hybrid	BioGRID	16169070
NEK6	SID6-1512	NIMA (never in mitosis gene a)-related kinase 6	Affinity Capture-MS	BioGRID	17353931
NFKBIA	IKBA \| MAD-3 \| NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	-	HPRD,BioGRID	9372968
NFKBIA	IKBA \| MAD-3 \| NFKBI		I-kappa-B-alpha interacts with Dlc-1.	BIND	9372968
NOS1	IHPS1 \| NOS \| nNOS	nitric oxide synthase 1 (neuronal)	-	HPRD	8864115
NRF1	ALPHA-PAL	nuclear respiratory factor 1	Affinity Capture-Western Reconstituted Complex	BioGRID	11069771
NTRK2	GP145-TrkB \| TRKB	neurotrophic tyrosine kinase, receptor, type 2	-	HPRD,BioGRID	11157096
PABPC1	PAB1 \| PABP \| PABP1 \| PABPC2 \| PABPL1	poly(A) binding protein, cytoplasmic 1	Affinity Capture-MS	BioGRID	17353931
PAK1	MGC130000 \| MGC130001 \| PAKalpha	p21 protein (Cdc42/Rac)-activated kinase 1	Affinity Capture-Western Biochemical Activity Reconstituted Complex Two-hybrid	BioGRID	15193260
PAN2	FLJ39360 \| KIAA0710 \| USP52 \| hPAN2	PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae)	DLC8 interacts with KIAA0710. This interaction was modeled on a demonstrated interaction between DLC8 from an unspecified species and human KIAA0710.	BIND	11148209
PARD3	ASIP \| Baz \| Bazooka \| FLJ21015 \| PAR3 \| PAR3alpha \| PARD3A \| SE2-5L16 \| SE2-5LT1 \| SE2-5T2	par-3 partitioning defective 3 homolog (C. elegans)	-	HPRD	14760703
PFKM	GSD7 \| MGC8699 \| PFK-1 \| PFK-M \| PFKX	phosphofructokinase, muscle	-	HPRD	14760703
PFKP	FLJ40226 \| PFK-C \| PFKF	phosphofructokinase, platelet	-	HPRD	14760703
PKIA	PRKACN1	protein kinase (cAMP-dependent, catalytic) inhibitor alpha	PIN interacts with PKIA.	BIND	11978406
PKIB	FLJ23817 \| PRKACN2	protein kinase (cAMP-dependent, catalytic) inhibitor beta	PIN interacts with PKIB.	BIND	11978406
PKIG	MGC126458 \| MGC126459	protein kinase (cAMP-dependent, catalytic) inhibitor gamma	PIN interacts with PKIG.	BIND	11978406
POLH	FLJ16395 \| FLJ21978 \| RAD30 \| RAD30A \| XP-V \| XPV	polymerase (DNA directed), eta	-	HPRD	14760703
RAB4A	HRES-1/RAB4 \| RAB4	RAB4A, member RAS oncogene family	-	HPRD,BioGRID	11243854
RGS2	G0S8	regulator of G-protein signaling 2, 24kDa	Two-hybrid	BioGRID	16169070
SHANK2	CORTBP1 \| CTTNBP1 \| ProSAP1 \| SHANK \| SPANK-3	SH3 and multiple ankyrin repeat domains 2	Affinity Capture-Western	BioGRID	10844022
SHROOM3	APXL3 \| KIAA1481 \| MSTP013 \| SHRM \| ShrmL	shroom family member 3	-	HPRD	14760703
SLC25A10	DIC	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	DIC interacts with LC8.	BIND	15117959
SNCG	BCSG1 \| SR	synuclein, gamma (breast cancer-specific protein 1)	Affinity Capture-MS	BioGRID	17353931
THAP8	FLJ32891	THAP domain containing 8	Two-hybrid	BioGRID	16169070
TP53BP1	53BP1 \| FLJ41424 \| MGC138366 \| p202	tumor protein p53 binding protein 1	Affinity Capture-Western Protein-peptide Two-hybrid	BioGRID	15611139
TRAF3IP3	DJ434O14.3 \| FLJ44151 \| MGC117354 \| MGC163289 \| T3JAM	TRAF3 interacting protein 3	Affinity Capture-MS	BioGRID	18782753
TUBA3C	TUBA2 \| bA408E5.3	tubulin, alpha 3c	-	HPRD	14760703
TUBB2C	TUBB2	tubulin, beta 2C	-	HPRD	14760703
TXNDC17	MGC14353 \| TRP14 \| TXNL5	thioredoxin domain containing 17	-	HPRD,BioGRID	14607843
VIM	FLJ36605	vimentin	-	HPRD	14760703
ZHX1	-	zinc fingers and homeoboxes 1	Two-hybrid	BioGRID	16169070
ZNF354A	EZNF \| HKL1 \| KID-1 \| KID1 \| TCF17	zinc finger protein 354A	-	HPRD	14760703

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-326	69	75	1A	hsa-miR-326	CCUCUGGGCCCUUCCUCCAG
miR-486	134	140	m8	hsa-miR-486	UCCUGUACUGAGCUGCCCCGAG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.