Gene Page: EIF3A

Summary
GeneID  8661
Symbol  EIF3A
Synonyms  EIF3|EIF3S10|KIAA0139|P167|TIF32|eIF3-p170|eIF3-theta|p180|p185
Description  eukaryotic translation initiation factor 3, subunit A
See related  HGNC:3271|MIM:602039|Ensembl:ENSG00000107581|HPRD:03618|
Locus tag  -
Gene type  protein-coding
Map location  10q26
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0069 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
DIS30.950.96
GSPT10.950.97
KPNA30.950.96
ZNF7700.950.96
SCYL20.940.96
FYTTD10.940.96
CAND10.940.97
ZNF4360.940.95
PIK3CA0.940.96
STRN30.940.96
Top 10 negatively co-expressed genes
FXYD1-0.76-0.87
MT-CO2-0.75-0.88
AF347015.31-0.75-0.86
AF347015.33-0.73-0.83
IFI27-0.72-0.85
AF347015.27-0.72-0.83
AF347015.8-0.72-0.85
MT-CYB-0.71-0.83
TSC22D4-0.71-0.79
AIFM3-0.71-0.75
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003735structural constituent of ribosomeIEA-
GO:0003743translation initiation factor activityIEA-
GO:0005515protein bindingIPI11169732 
GO:0005198structural molecule activityNAS9150439 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006446regulation of translational initiationTAS9054404 
GO:0006412translationIEA-
GO:0008150biological_processND2110361 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP12588972 
GO:0005840ribosomeIEA-
GO:0005852eukaryotic translation initiation factor 3 complexTAS9054404 
GO:0005737cytoplasmNAS9150439 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DISC1C1orf136 | FLJ13381 | FLJ21640 | FLJ25311 | FLJ41105 | KIAA0457 | SCZD9disrupted in schizophrenia 1Affinity Capture-Western
Two-hybrid		BioGRID12812986 
EIF1BGC20eukaryotic translation initiation factor 1BAffinity Capture-MSBioGRID17353931 
EIF3BEIF3-ETA | EIF3-P110 | EIF3-P116 | EIF3S9 | MGC104664 | MGC131875 | PRT1eukaryotic translation initiation factor 3, subunit Bp150 interacts with hPrt1.BIND11169732 
-HPRD,BioGRID8995410 |9822659 
EIF3CEIF3S8 | FLJ78287 | MGC189744 | eIF3-p110eukaryotic translation initiation factor 3, subunit CCo-purificationBioGRID14519125 
EIF3DEIF3S7 | MGC126526 | MGC17258 | eIF3-p66 | eIF3-zetaeukaryotic translation initiation factor 3, subunit DAffinity Capture-MS
Co-purification		BioGRID14519125 |17353931 
EIF3EEIF3-P48 | EIF3S6 | INT6 | eIF3-p46eukaryotic translation initiation factor 3, subunit EAffinity Capture-MS
Affinity Capture-Western
Co-purification		BioGRID11590142 |14519125 
|17353931 
EIF3EIPEIF3S11 | EIF3S6IP | HSPC021 | HSPC025 | MSTP005eukaryotic translation initiation factor 3, subunit E interacting proteinAffinity Capture-MS
Affinity Capture-Western
Co-fractionation		BioGRID11590142 |17353931 
EIF3FEIF3S5 | eIF3-p47eukaryotic translation initiation factor 3, subunit FAffinity Capture-MS
Co-purification		BioGRID14519125 |17353931 
EIF3GEIF3-P42 | EIF3S4 | eIF3-delta | eIF3-p44eukaryotic translation initiation factor 3, subunit G-HPRD,BioGRID9822659 
EIF3HEIF3S3 | MGC102958 | eIF3-gamma | eIF3-p40eukaryotic translation initiation factor 3, subunit HAffinity Capture-MS
Co-purification		BioGRID14519125 |17353931 
EIF3IEIF3S2 | PRO2242 | TRIP-1 | TRIP1 | eIF3-beta | eIF3-p36eukaryotic translation initiation factor 3, subunit I-HPRD,BioGRID8995409 
EIF3JEIF3S1 | eIF3-alpha | eIF3-p35eukaryotic translation initiation factor 3, subunit J-HPRD,BioGRID9822659 
EIF3KARG134 | EIF3-p28 | EIF3S12 | HSPC029 | M9 | MSTP001 | PLAC-24 | PLAC24 | PRO1474 | PTD001eukaryotic translation initiation factor 3, subunit K-HPRD,BioGRID14519125 
EIF3MB5 | FLJ29030 | GA17 | PCID1 | hfl-B5eukaryotic translation initiation factor 3, subunit MAffinity Capture-MSBioGRID17353931 
EIF4A1DDX2A | EIF-4A | EIF4Aeukaryotic translation initiation factor 4A, isoform 1Affinity Capture-MSBioGRID17353931 
EIF4A2BM-010 | DDX2B | EIF4A | EIF4Feukaryotic translation initiation factor 4A, isoform 2Affinity Capture-MSBioGRID17353931 
EIF4BEIF-4B | PRO1843eukaryotic translation initiation factor 4B-HPRD,BioGRID8816444 
EIF4G1DKFZp686A1451 | EIF4F | EIF4G | p220eukaryotic translation initiation factor 4 gamma, 1Affinity Capture-WesternBioGRID16541103 
EIF4G2AAG1 | DAP5 | FLJ41344 | NAT1 | p97eukaryotic translation initiation factor 4 gamma, 2Affinity Capture-WesternBioGRID9418880 |10611228 
KRT7CK7 | K2C7 | K7 | MGC129731 | MGC3625 | SCLkeratin 7p150 interacts with K7.BIND11169732 
MCCDKFZp762O1615 | FLJ38893 | FLJ46755 | MCC1mutated in colorectal cancersAffinity Capture-MSBioGRID17353931 
TFE3RCCP2 | TFEA | bHLHe33transcription factor binding to IGHM enhancer 3Affinity Capture-MSBioGRID17353931 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-15/16/195/424/497950956m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-182703709m8hsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-18692991A,m8hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-23278284m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-26571577m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-3232782841Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-3625258m8hsa-miR-362AAUCCUUGGAACCUAGGUGUGAGU
miR-369-3p59651Ahsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-3745965m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-380-5p74801Ahsa-miR-380-5pUGGUUGACCAUAGAACAUGCGC
hsa-miR-563AGGUUGACAUACGUUUCCC
miR-381132138m8hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-409-3p47531Ahsa-miR-409-3pCGAAUGUUGCUCGGUGAACCCCU
miR-505873879m8hsa-miR-505GUCAACACUUGCUGGUUUCCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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