Gene Page

Gene Page: EED

Summary

GeneID

8726

Symbol

EED

Synonyms

HEED|WAIT1

Description

embryonic ectoderm development

Locus tag

Gene type

protein-coding

Map location

11q14.2-q22.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Expression

P value: 1.41

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

ATL1

0.94

NKIRAS1

0.93

ATP6AP2

0.91

COQ10B

0.91

0.90

ATP6V1D

0.90

0.93

C2orf30

0.90

PCMT1

0.90

0.91

GHITM

0.90

0.91

IMPA1

0.90

0.92

PDHX

0.90

0.88

Top 10 negatively co-expressed genes

AF347015.18

-0.51

-0.31

AF347015.21

-0.49

-0.23

EFEMP2

-0.47

-0.51

AF347015.2

-0.46

-0.25

AL022328.1

-0.46

-0.47

AC010300.1

-0.45

-0.42

C10orf108

-0.44

-0.43

AC100783.1

-0.44

-0.38

AP002478.3

-0.44

-0.37

EIF4EBP3

-0.44

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0016564

transcription repressor activity

NAS

9584199

GO:0042802

identical protein binding

IPI

11124122

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006355

regulation of transcription, DNA-dependent

IEA

GO:0016568

chromatin modification

IEA

GO:0016481

negative regulation of transcription

NAS

9584199

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

NAS

9584199

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AEBP2	MGC17922	AE binding protein 2	-	HPRD	15225548
AEBP2	MGC17922	AE binding protein 2	EED interacts with AEBP2.	BIND	15225548
ANXA5	ANX5 \| ENX2 \| PP4	annexin A5	-	HPRD,BioGRID	9584197
EZH1	KIAA0388	enhancer of zeste homolog 1 (Drosophila)	Eed interacts with EZH1.	BIND	9566901
EZH2	ENX-1 \| EZH1 \| KMT6 \| MGC9169	enhancer of zeste homolog 2 (Drosophila)	Affinity Capture-Western Co-fractionation Reconstituted Complex Two-hybrid	BioGRID	9584197 \|9742080 \|10581039
			-	HPRD	9584197\|10581039
			EZH2 interacts with EED.	BIND	15225548
HDAC1	DKFZp686H12203 \| GON-10 \| HD1 \| RPD3 \| RPD3L1	histone deacetylase 1	-	HPRD,BioGRID	10581039
HDAC2	RPD3 \| YAF1	histone deacetylase 2	-	HPRD,BioGRID	10581039
ITGA4	CD49D \| IA4 \| MGC90518	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	Integrin alpha-4 interacts with WAIT-1.	BIND	9765275
ITGA4	CD49D \| IA4 \| MGC90518		-	HPRD,BioGRID	9765275
ITGAE	CD103 \| HUMINAE \| MGC141996	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	Integrin alpha-E interacts with WAIT-1.	BIND	9765275
ITGAE	CD103 \| HUMINAE \| MGC141996		-	HPRD,BioGRID	9765275
ITGB7	-	integrin, beta 7	-	HPRD,BioGRID	9765275
ITGB7	-	integrin, beta 7	Integrin beta-7 interacts with WAIT-1.	BIND	9765275
PPP1CA	MGC15877 \| MGC1674 \| PP-1A \| PPP1A	protein phosphatase 1, catalytic subunit, alpha isoform	Reconstituted Complex	BioGRID	12788942
PPP1R8	ARD-1 \| ARD1 \| NIPP-1 \| NIPP1 \| PRO2047	protein phosphatase 1, regulatory (inhibitor) subunit 8	-	HPRD,BioGRID	12788942
SUZ12	CHET9 \| JJAZ1 \| KIAA0160	suppressor of zeste 12 homolog (Drosophila)	EED interacts with SUZ12.	BIND	15225548
TGS1	DKFZp762A163 \| FLJ22995 \| NCOA6IP \| PIMT \| PIPMT	trimethylguanosine synthase homolog (S. cerevisiae)	-	HPRD,BioGRID	12943661
YY1	DELTA \| INO80S \| NF-E1 \| UCRBP \| YIN-YANG-1	YY1 transcription factor	YY1 interacts with EED.	BIND	14610174
YY1	DELTA \| INO80S \| NF-E1 \| UCRBP \| YIN-YANG-1	YY1 transcription factor	EED interacts with YY1.	BIND	11158321

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	161	167	m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-181	126	133	1A,m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-186	154	160	m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-30-5p	147	154	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.