Gene Page: ADAM7
Summary ?
| GeneID | 8756 |
| Symbol | ADAM7 |
| Synonyms | ADAM 7|ADAM-7|EAPI|GP-83|GP83 |
| Description | ADAM metallopeptidase domain 7 |
| Reference | MIM:607310|HGNC:HGNC:214|Ensembl:ENSG00000069206|HPRD:07391|Vega:OTTHUMG00000097859 |
| Gene type | protein-coding |
| Map location | 8p21.2 |
| Pascal p-value | 0.008 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.031 | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.03086 | |
| GSMA_IIE | Genome scan meta-analysis (European-ancestry samples) | Psr: 0.00057 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SUZ12 | 0.94 | 0.95 |
| AP3M1 | 0.94 | 0.94 |
| DHX15 | 0.93 | 0.95 |
| PRPF40A | 0.93 | 0.93 |
| MSH6 | 0.93 | 0.93 |
| XPO1 | 0.93 | 0.95 |
| KIAA1429 | 0.93 | 0.95 |
| NCBP1 | 0.93 | 0.95 |
| CRNKL1 | 0.93 | 0.95 |
| HNRNPK | 0.93 | 0.93 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.71 | -0.86 |
| MT-CO2 | -0.71 | -0.87 |
| FXYD1 | -0.70 | -0.86 |
| AF347015.33 | -0.69 | -0.84 |
| IFI27 | -0.69 | -0.86 |
| MT-CYB | -0.68 | -0.83 |
| AF347015.27 | -0.68 | -0.83 |
| AF347015.8 | -0.68 | -0.85 |
| HLA-F | -0.67 | -0.77 |
| AIFM3 | -0.67 | -0.76 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004222 | metalloendopeptidase activity | IEA | - | |
| GO:0008270 | zinc ion binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006508 | proteolysis | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0016021 | integral to membrane | IEA | - | |
| GO:0005886 | plasma membrane | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| NABA ECM REGULATORS | 238 | 125 | All SZGR 2.0 genes in this pathway |
| NABA MATRISOME ASSOCIATED | 753 | 411 | All SZGR 2.0 genes in this pathway |
| NABA MATRISOME | 1028 | 559 | All SZGR 2.0 genes in this pathway |