Gene Page: TNFRSF6B

Summary ?
GeneID8771
SymbolTNFRSF6B
SynonymsDCR3|DJ583P15.1.1|M68|M68E|TR6
Descriptiontumor necrosis factor receptor superfamily member 6b
ReferenceMIM:603361|HGNC:HGNC:11921|Ensembl:ENSG00000243509|HPRD:04527|Vega:OTTHUMG00000143724
Gene typeprotein-coding
Map location20q13.3
Pascal p-value0.006
Sherlock p-value0.858
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
ExpressionMeta-analysis of gene expressionP value: 1.556 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs11260821chr116931642TNFRSF6B87710.18trans
rs2842861chr1156172498TNFRSF6B87710.09trans
rs890527chr3140774852TNFRSF6B87710.02trans
rs16846456chr3172757337TNFRSF6B87710.05trans
rs3900348chr4104509166TNFRSF6B87710.11trans
rs4446310chr4104509230TNFRSF6B87710.15trans
rs4580655chr4104529273TNFRSF6B87710.07trans
rs1678893chr531763244TNFRSF6B87710.17trans
rs12524136chr684935440TNFRSF6B87710.05trans
rs10247386chr769173543TNFRSF6B87710.17trans
rs7807249chr7131615735TNFRSF6B87710.11trans
rs9416364chr1056253021TNFRSF6B87710.03trans
rs4303487chr1690033254TNFRSF6B87710.19trans
rs16979927chr2055019249TNFRSF6B87710.15trans
rs16982879chrX92924110TNFRSF6B87710.03trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AC008074.30.920.91
AFTPH0.910.90
RABGEF10.900.89
RTN10.900.89
MAPK140.900.89
UBQLN10.900.87
CSRP2BP0.900.87
UBE2Z0.890.89
UBQLN20.890.87
EIF4ENIF10.890.88
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MT-CO2-0.79-0.75
AF347015.31-0.77-0.74
AF347015.21-0.76-0.76
AF347015.8-0.76-0.74
MT-CYB-0.75-0.71
FXYD1-0.75-0.73
AF347015.26-0.74-0.70
AF347015.33-0.74-0.69
HIGD1B-0.73-0.73
AF347015.2-0.73-0.70

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityTAS9872321 
GO:0003676nucleic acid bindingIEA-
GO:0005515protein bindingIPI10318773 
GO:0005524ATP bindingIEA-
GO:0016818hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydridesIEA-
GO:0008026ATP-dependent helicase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006139nucleobase, nucleoside, nucleotide and nucleic acid metabolic processIEA-
GO:0006916anti-apoptosisTAS9872321 
GO:0006915apoptosisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005625soluble fractionTAS9872321 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267161All SZGR 2.0 genes in this pathway
ST FAS SIGNALING PATHWAY 6554All SZGR 2.0 genes in this pathway
CHIN BREAST CANCER COPY NUMBER UP 2718All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584356All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 20Q12 Q13 AMPLICON 14976All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT UP 8961All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP 242159All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418245All SZGR 2.0 genes in this pathway