Gene Page: NAPA

Summary ?
GeneID8775
SymbolNAPA
SynonymsSNAPA
DescriptionNSF attachment protein alpha
ReferenceMIM:603215|HGNC:HGNC:7641|Ensembl:ENSG00000105402|HPRD:04447|Vega:OTTHUMG00000183294
Gene typeprotein-coding
Map location19q13.33
Pascal p-value0.443
Fetal beta-0.963
DMG1 (# studies)
eGeneMeta
SupportCANABINOID
DOPAMINE
EXOCYTOSIS
SEROTONIN
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_clathrin
G2Cdb.human_Synaptosome
CompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg146604461948015621NAPA3.175E-40.4270.04DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0019905syntaxin bindingIEASynap (GO term level: 5)-
GO:0005515protein bindingIPI16189514 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007420brain developmentIEABrain (GO term level: 7)-
GO:0030182neuron differentiationIEAneuron (GO term level: 8)-
GO:0006944membrane fusionTAS8455721 
GO:0006886intracellular protein transportIEA-
GO:0006891intra-Golgi vesicle-mediated transportTAS8455721 
GO:0016192vesicle-mediated transportIEA-
GO:0045176apical protein localizationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005794Golgi apparatusIEA-
GO:0005783endoplasmic reticulumIEA-
GO:0016020membraneIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GOSR1GOLIM2 | GOS-28 | GOS28 | GOS28/P28 | GS28 | P28golgi SNAP receptor complex member 1-HPRD9325254 
GOSR2Bos1 | GS27golgi SNAP receptor complex member 2-HPRD9349823 
NSFSKD2N-ethylmaleimide-sensitive factor-HPRD,BioGRID9362506 
RTN4ASY | NI220/250 | NOGO | NOGO-A | NOGOC | NSP | NSP-CL | Nbla00271 | Nbla10545 | Nogo-B | Nogo-C | RTN-X | RTN4-A | RTN4-B1 | RTN4-B2 | RTN4-Creticulon 4Two-hybridBioGRID16189514 
SNAP23HsT17016 | SNAP23A | SNAP23Bsynaptosomal-associated protein, 23kDaAffinity Capture-Western
Two-hybrid		BioGRID16189514 
SNAP25FLJ23079 | RIC-4 | RIC4 | SEC9 | SNAP | SNAP-25 | bA416N4.2 | dJ1068F16.2synaptosomal-associated protein, 25kDaReconstituted ComplexBioGRID7622514 
STX12MGC51957 | STX13 | STX14syntaxin 12-HPRD,BioGRID9507000 |9817754 
STX1AHPC-1 | STX1 | p35-1syntaxin 1A (brain)Affinity Capture-Western
Reconstituted Complex		BioGRID7553862 |7622514 
STX4STX4A | p35-2syntaxin 4Affinity Capture-Western
Two-hybrid		BioGRID16189514 
STX5SED5 | STX5Asyntaxin 5Reconstituted Complex
Two-hybrid		BioGRID9506515 |16189514 
STX7-syntaxin 7-HPRD,BioGRID9417091 
STX8CARBsyntaxin 8-HPRD,BioGRID10683148 
TRPC3TRP3transient receptor potential cation channel, subfamily C, member 3TRPC3 interacts with alpha-SNAP.BIND15327778 
TRPC3TRP3transient receptor potential cation channel, subfamily C, member 3-HPRD15327778 
VAMP2FLJ11460 | SYB2 | VAMP-2vesicle-associated membrane protein 2 (synaptobrevin 2)Reconstituted ComplexBioGRID7622514 
VAMP8EDBvesicle-associated membrane protein 8 (endobrevin)-HPRD,BioGRID9614193 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME MEMBRANE TRAFFICKING 12974All SZGR 2.0 genes in this pathway
REACTOME TRANS GOLGI NETWORK VESICLE BUDDING 6031All SZGR 2.0 genes in this pathway
REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS 5327All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP 368234All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA BY DMOG DN 5940All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584395All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN 160110All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS POSTNATAL 6350All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544307All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN 153120All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM DN 8666All SZGR 2.0 genes in this pathway
LEE AGING NEOCORTEX UP 8959All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP 298174All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548370All SZGR 2.0 genes in this pathway