Gene Page: TNFRSF10B

Summary
GeneID  8795
Symbol  TNFRSF10B
Synonyms  CD262|DR5|KILLER|KILLER/DR5|TRAIL-R2|TRAILR2|TRICK2|TRICK2A|TRICK2B|TRICKB|ZTNFR9
Description  tumor necrosis factor receptor superfamily, member 10b
See related  HGNC:11905|MIM:603612|Ensembl:ENSG00000120889|HPRD:04680|
Locus tag  -
Gene type  protein-coding
Map location  8p22-p21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.031 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.00057 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.03086 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
LARP4B0.950.96
INPP4A0.930.95
KIAA03170.930.94
CEP680.930.95
DCLK10.920.94
SMG70.920.94
MAP3K130.920.93
ATCAY0.920.94
WDR370.920.93
MAPRE20.910.93
Top 10 negatively co-expressed genes
FXYD1-0.75-0.75
AF347015.31-0.73-0.76
HIGD1B-0.73-0.77
MT-CO2-0.72-0.76
TLCD1-0.71-0.73
AC021016.1-0.70-0.73
CLDN10-0.70-0.72
AF347015.21-0.70-0.77
HSD17B14-0.69-0.71
CST3-0.69-0.73
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0004872receptor activityNAS9311998 
GO:0005515protein bindingIEA-
GO:0008656caspase activator activityNAS-
GO:0045569TRAIL bindingNAS9373179 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008625induction of apoptosis via death domain receptorsNAS9311998 
GO:0007250activation of NF-kappaB-inducing kinase activityNAS9430227 |11464292 
GO:0007166cell surface receptor linked signal transductionTAS9311998 
GO:0007165signal transductionIEA-
GO:0008633activation of pro-apoptotic gene productsEXP14644197 
GO:0006919caspase activationNAS-
GO:0042981regulation of apoptosisNAS10549288 
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIEP12761501 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016021integral to membraneIC9311998 
GO:0005886plasma membraneEXP8777713 |10894160 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARHGDIAGDIA1 | MGC117248 | RHOGDI | RHOGDI-1Rho GDP dissociation inhibitor (GDI) alphaCo-purificationBioGRID15659383 
BIDFP497 | MGC15319 | MGC42355BH3 interacting domain death agonistCo-purificationBioGRID15659383 
CASP10ALPS2 | FLICE2 | MCH4caspase 10, apoptosis-related cysteine peptidaseAffinity Capture-Western
Co-purification		BioGRID9325248 |15659383 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidaseAffinity Capture-Western
Co-purification		BioGRID9325248 |15659383 
-HPRD12218097 
CFLARCASH | CASP8AP1 | CLARP | Casper | FLAME | FLAME-1 | FLAME1 | FLIP | I-FLICE | MRIT | c-FLIP | c-FLIPL | c-FLIPR | c-FLIPSCASP8 and FADD-like apoptosis regulator-HPRD11193041 
Affinity Capture-WesternBioGRID9325248 
EZRCVIL | CVL | DKFZp762H157 | FLJ26216 | MGC1584 | VIL2ezrinCo-purificationBioGRID15659383 
FADDGIG3 | MGC8528 | MORT1Fas (TNFRSF6)-associated via death domain-HPRD,BioGRID9430227 
FASALPS1A | APO-1 | APT1 | CD95 | FAS1 | FASTM | TNFRSF6Fas (TNF receptor superfamily, member 6)Co-purificationBioGRID15659383 
FASLGAPT1LG1 | CD178 | CD95L | FASL | TNFSF6Fas ligand (TNF superfamily, member 6)Co-purificationBioGRID15659383 
MAPK8JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1mitogen-activated protein kinase 8Co-purificationBioGRID15659383 
MSN-moesinCo-purificationBioGRID15659383 
PRKCDMAY1 | MGC49908 | PKCD | nPKC-deltaprotein kinase C, deltaPRKCD (PKC-delta) interacts with TNFRSF10B (DR5) RARE.BIND12805378 
RARANR1B1 | RARretinoic acid receptor, alphaRARA (RAR-alpha) interacts with TNFRSF10B (DR5) RARE.BIND12805378 
RHOAARH12 | ARHA | RHO12 | RHOH12ras homolog gene family, member ACo-purificationBioGRID15659383 
RIPK1FLJ39204 | RIP | RIP1receptor (TNFRSF)-interacting serine-threonine kinase 1-HPRD,BioGRID9430227 
TIMM50MGC102733 | TIM50 | TIM50Ltranslocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)Two-hybridBioGRID15044455 
TNFRSF1ACD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60tumor necrosis factor receptor superfamily, member 1ACo-purificationBioGRID15659383 
TNFSF10APO2L | Apo-2L | CD253 | TL2 | TRAILtumor necrosis factor (ligand) superfamily, member 10TNFSF10 (TRAIL) interacts with TNFRSF10B (DR5).BIND15688023 
-HPRD9311998 |10549288 
|15110168 
Affinity Capture-MS
Co-crystal Structure
Reconstituted Complex		BioGRID9311998 |10549288 
|11094155 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53p53 interacts with DR5.BIND15607964 
TRADDHs.89862 | MGC11078TNFRSF1A-associated via death domain-HPRD,BioGRID9430227 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-410252825341Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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