Gene Page: IL1RL2
Summary ?
| GeneID | 8808 |
| Symbol | IL1RL2 |
| Synonyms | IL-1Rrp2|IL-36R|IL1R-rp2|IL1RRP2 |
| Description | interleukin 1 receptor like 2 |
| Reference | MIM:604512|HGNC:HGNC:5999|Ensembl:ENSG00000115598|HPRD:05150|Vega:OTTHUMG00000130776 |
| Gene type | protein-coding |
| Map location | 2q12 |
| Pascal p-value | 0.015 |
| eGene | Nucleus accumbens basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.0004 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| UBLCP1 | 0.91 | 0.91 |
| DLD | 0.90 | 0.90 |
| SUCLA2 | 0.89 | 0.89 |
| NARS | 0.89 | 0.88 |
| USO1 | 0.89 | 0.86 |
| AGGF1 | 0.88 | 0.86 |
| VPS35 | 0.88 | 0.86 |
| GRSF1 | 0.88 | 0.86 |
| DNAJA2 | 0.88 | 0.89 |
| GFM1 | 0.88 | 0.85 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.62 | -0.42 |
| MT-CO2 | -0.57 | -0.45 |
| AF347015.18 | -0.57 | -0.44 |
| AF347015.8 | -0.57 | -0.44 |
| AF347015.2 | -0.56 | -0.42 |
| AF347015.31 | -0.55 | -0.46 |
| MT-CYB | -0.54 | -0.44 |
| HIGD1B | -0.53 | -0.40 |
| AF347015.15 | -0.52 | -0.42 |
| CSAG1 | -0.51 | -0.42 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004888 | transmembrane receptor activity | IEA | - | |
| GO:0004909 | interleukin-1, Type I, activating receptor activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006968 | cellular defense response | TAS | 8332913 | |
| GO:0007165 | signal transduction | TAS | 1833184 | |
| GO:0045087 | innate immune response | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0016020 | membrane | IEA | - | |
| GO:0005887 | integral to plasma membrane | TAS | 1833184 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| HOFMANN CELL LYMPHOMA DN | 39 | 29 | All SZGR 2.0 genes in this pathway |
| SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 | 419 | 273 | All SZGR 2.0 genes in this pathway |
| GAVIN FOXP3 TARGETS CLUSTER P4 | 100 | 62 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MCV6 HCP WITH H3K27ME3 | 435 | 318 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP A | 898 | 516 | All SZGR 2.0 genes in this pathway |
| DURAND STROMA NS UP | 162 | 103 | All SZGR 2.0 genes in this pathway |