Gene Page: CFLAR

Summary
GeneID  8837
Symbol  CFLAR
Synonyms  CASH|CASP8AP1|CLARP|Casper|FLAME|FLAME-1|FLAME1|FLIP|I-FLICE|MRIT|c-FLIP|c-FLIPL|c-FLIPR|c-FLIPS
Description  CASP8 and FADD-like apoptosis regulator
See related  HGNC:1876|MIM:603599|Ensembl:ENSG00000003402|HPRD:04671|
Locus tag  -
Gene type  protein-coding
Map location  2q33-q34
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 4.144 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
GPD1L0.910.94
ACVR1B0.900.93
PUM20.900.94
RNF1110.900.94
NNT0.900.92
EPM2AIP10.900.93
POLR3A0.890.92
RLBP1L10.890.90
ZBTB240.890.92
LASS60.890.91
Top 10 negatively co-expressed genes
FXYD1-0.71-0.81
AF347015.31-0.70-0.79
MT-CO2-0.70-0.80
HSD17B14-0.70-0.76
SERPINB6-0.70-0.73
S100A16-0.69-0.79
HIGD1B-0.69-0.80
IFI27-0.68-0.78
AF347015.33-0.67-0.75
TLCD1-0.67-0.78
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI11741985 
GO:0004197cysteine-type endopeptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006508proteolysisIEA-
GO:0006916anti-apoptosisTAS9217161 
GO:0008624induction of apoptosis by extracellular signalsTAS9208847 
GO:0042981regulation of apoptosisIEA-
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIEP12761501 
GO:0044419interspecies interaction between organismsIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BCL2L1BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xSBCL2-like 1-HPRD,BioGRID9326610 
MRIT-alpha-1 interacts with BclXL. This interaction was modelled on a demonstrated interaction between human MRIT-alpha-1 and BclXL from an unspecified species.BIND9326610 
CASP10ALPS2 | FLICE2 | MCH4caspase 10, apoptosis-related cysteine peptidase-HPRD9208847 |9228018 
|9289491 
Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID9228018 |9289491 
|12887920 
CASP3CPP32 | CPP32B | SCA-1caspase 3, apoptosis-related cysteine peptidase-HPRD,BioGRID9208847 
MRIT-beta-1 interacts with YAMA. This interaction was modelled on a demonstrated interaction between human MRIT-beta-1 and YAMA from an unspecified species.BIND9326610 
MRIT-alpha-1 interacts with YAMA. This interaction was modelled on a demonstrated interaction between human MRIT-alpha-1 and YAMA from an unspecified species.BIND9326610 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidaseMRIT-beta-1 interacts with FLICE. This interaction was modelled on a demonstrated interaction between human MRIT-beta-1 and FLICE from an unspecified species.BIND9326610 
Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID9208847 |9228018 
|9289491 |9326610 
|11741985 |12215447 
|12887920 
-HPRD9208847 |9289491 
|12215447 
MRIT-alpha-1 interacts with FLICE. This interaction was modelled on a demonstrated interaction between human MRIT-alpha-1 and FLICE from an unspecified species.BIND9326610 
CFLARCASH | CASP8AP1 | CLARP | Casper | FLAME | FLAME-1 | FLAME1 | FLIP | I-FLICE | MRIT | c-FLIP | c-FLIPL | c-FLIPR | c-FLIPSCASP8 and FADD-like apoptosis regulatorTwo-hybridBioGRID9228018 
DAXXBING2 | DAP6 | EAP1 | MGC126245 | MGC126246death-domain associated proteinc-FLIP(L) interacts with Daxx.BIND14637155 
DEDDCASP8IP1 | DEDD1 | DEFT | FLDED1 | KE05death effector domain containing-HPRD,BioGRID11741985 
DEDD2FLAME-3death effector domain containing 2-HPRD,BioGRID11741985 |11965497 
DOK2p56DOK | p56dok-2docking protein 2, 56kDaAffinity Capture-MSBioGRID17353931 
FADDGIG3 | MGC8528 | MORT1Fas (TNFRSF6)-associated via death domainMRIT-beta-1 interacts with FADD. This interaction was modelled on a demonstrated interaction between human MRIT-beta-1 and FADD from an unspecified species.BIND9326610 
-HPRD9208847 |11965497 
c-FLIP interacts with FADD.BIND12220669 
Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID9208847 |9228018 
|9326610 
FASALPS1A | APO-1 | APT1 | CD95 | FAS1 | FASTM | TNFRSF6Fas (TNF receptor superfamily, member 6)Affinity Capture-WesternBioGRID9208847 |9325248 
IKBKBFLJ40509 | IKK-beta | IKK2 | IKKB | MGC131801 | NFKBIKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta-HPRD11002417 
MAP3K14FTDCR1B | HS | HSNIK | NIKmitogen-activated protein kinase kinase kinase 14Affinity Capture-WesternBioGRID11002417 
NOD1CARD4 | CLR7.1 | NLRC1nucleotide-binding oligomerization domain containing 1Affinity Capture-WesternBioGRID10329646 
NOL3ARC | CARD2 | MYC | MYP | NOP | NOP30nucleolar protein 3 (apoptosis repressor with CARD domain)Phenotypic SuppressionBioGRID9560245 
RAF1CRAF | NS5 | Raf-1 | c-Rafv-raf-1 murine leukemia viral oncogene homolog 1-HPRD,BioGRID10837247 
RIPK1FLJ39204 | RIP | RIP1receptor (TNFRSF)-interacting serine-threonine kinase 1-HPRD,BioGRID10837247 
RIPK2CARD3 | CARDIAK | CCK | GIG30 | RICK | RIP2receptor-interacting serine-threonine kinase 2-HPRD,BioGRID9575181 
SF3B3KIAA0017 | RSE1 | SAP130 | SF3b130 | STAF130splicing factor 3b, subunit 3, 130kDaAffinity Capture-MSBioGRID17353931 
TNFRSF10AAPO2 | CD261 | DR4 | MGC9365 | TRAILR-1 | TRAILR1tumor necrosis factor receptor superfamily, member 10aAffinity Capture-WesternBioGRID9325248 
TNFRSF10BCD262 | DR5 | KILLER | KILLER/DR5 | TRAIL-R2 | TRAILR2 | TRICK2 | TRICK2A | TRICK2B | TRICKB | ZTNFR9tumor necrosis factor receptor superfamily, member 10b-HPRD11193041 
Affinity Capture-WesternBioGRID9325248 
TRAF1EBI6 | MGC:10353TNF receptor-associated factor 1-HPRD,BioGRID9208847 
TRAF2MGC:45012 | TRAP | TRAP3TNF receptor-associated factor 2-HPRD,BioGRID9208847 
TRAF3CAP-1 | CD40bp | CRAF1 | LAP1TNF receptor-associated factor 3Affinity Capture-WesternBioGRID10837247 
 


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