Gene Page: EIF2B4

Summary ?
GeneID8890
SymbolEIF2B4
SynonymsEIF-2B|EIF2B|EIF2Bdelta
Descriptioneukaryotic translation initiation factor 2B subunit delta
ReferenceMIM:606687|HGNC:HGNC:3260|Ensembl:ENSG00000115211|HPRD:09459|Vega:OTTHUMG00000151927
Gene typeprotein-coding
Map location2p23.3
Pascal p-value0.001
Sherlock p-value0.606
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs1568778chr7109250931EIF2B488900.09trans
rs711457chr7109264996EIF2B488900.11trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AGTPBP10.900.93
MDGA20.890.91
CLASP20.890.93
WDR440.890.92
RAB9B0.880.91
PAPD50.880.92
PCYOX10.880.91
RTN40.870.92
GNPTAB0.870.91
MGEA50.870.91
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.70-0.80
MT-CO2-0.69-0.81
FXYD1-0.69-0.79
TSC22D4-0.67-0.75
SLC25A18-0.67-0.76
ROM1-0.67-0.77
AF347015.33-0.67-0.76
MT-CYB-0.67-0.77
HIGD1B-0.66-0.79
HSD17B14-0.66-0.75

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005085guanyl-nucleotide exchange factor activityIDA11323413 
GO:0005085guanyl-nucleotide exchange factor activityIMP15054402 
GO:0003743translation initiation factor activityIDA16289705 
GO:0003743translation initiation factor activityIEA-
GO:0005515protein bindingIPI15060152 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0014003oligodendrocyte developmentIMPaxon, oligodendrocyte, Glial (GO term level: 10)15217090 
GO:0042552myelinationIMPneuron, axon, Brain, oligodendrocyte (GO term level: 13)14566705 
GO:0001541ovarian follicle developmentIMP15507143 
GO:0006413translational initiationIDA16289705 
GO:0006417regulation of translationNAS12556349 
GO:0009408response to heatISS-
GO:0009408response to heatTAS12499492 
GO:0009749response to glucose stimulusISS-
GO:0043434response to peptide hormone stimulusISS-
GO:0044237cellular metabolic processIEA-
GO:0051716cellular response to stimulusIDA8626696 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005851eukaryotic translation initiation factor 2B complexIDA11323413 |15060152 
GO:0005737cytoplasmIDA11323413 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BIOCARTA VEGF PATHWAY 2918All SZGR 2.0 genes in this pathway
REACTOME TRANSLATION 22275All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518242All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431263All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS DN 352225All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517309All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS 185114All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION DN 187122All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION DN 169112All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE DN 245154All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337230All SZGR 2.0 genes in this pathway
KIM GASTRIC CANCER CHEMOSENSITIVITY 10364All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566371All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546362All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351238All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605377All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756494All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682440All SZGR 2.0 genes in this pathway
HOLLEMAN DAUNORUBICIN B ALL UP 109All SZGR 2.0 genes in this pathway
HOLLEMAN DAUNORUBICIN ALL UP 75All SZGR 2.0 genes in this pathway