Gene Page: EIF2B3

Summary
GeneID  8891
Symbol  EIF2B3
Synonyms  EIF-2B|EIF2Bgamma
Description  eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
See related  HGNC:3259|MIM:606273|Ensembl:ENSG00000070785|HPRD:09379|
Locus tag  RP5-882O7.2
Gene type  protein-coding
Map location  1p34.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.475 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
EPHX20.710.67
SOX130.680.74
ANKRD350.670.71
PHKG10.650.64
KATNAL20.650.68
PODN0.650.77
NKX2-20.650.68
FMO20.650.65
TPPP30.640.73
AIFM30.640.77
Top 10 negatively co-expressed genes
BZW2-0.55-0.70
STMN1-0.55-0.69
CRMP1-0.54-0.64
KIAA1949-0.54-0.55
NR2C2AP-0.54-0.71
HN1-0.54-0.66
C19orf57-0.54-0.61
ZNF124-0.54-0.70
TUBB-0.54-0.65
CD24-0.54-0.64
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005085guanyl-nucleotide exchange factor activityIDA11323413 
GO:0005085guanyl-nucleotide exchange factor activityIMP15054402 
GO:0003743translation initiation factor activityIDA10900014 |16289705 
GO:0003743translation initiation factor activityIEA-
GO:0005515protein bindingIPI15060152 
GO:0016779nucleotidyltransferase activityIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0014003oligodendrocyte developmentIMPaxon, oligodendrocyte, Glial (GO term level: 10)15217090 
GO:0006413translational initiationIDA10900014 |16289705 
GO:0009408response to heatISS-
GO:0009408response to heatTAS12499492 
GO:0009749response to glucose stimulusISS-
GO:0009058biosynthetic processIEA-
GO:0043434response to peptide hormone stimulusISS-
GO:0051716cellular response to stimulusIDA8626696 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005851eukaryotic translation initiation factor 2B complexIDA11323413 |15060152 
GO:0005737cytoplasmIDA11323413 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EIF2B1EIF-2B | EIF-2Balpha | EIF2B | EIF2BA | MGC117409 | MGC125868 | MGC125869eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDaAffinity Capture-MSBioGRID17353931 
EIF2B2EIF-2Bbeta | EIF2Beukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa-HPRD10805739 
EIF2B4DKFZp586J0119 | EIF-2B | EIF2B | EIF2Bdeltaeukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa-HPRD10805739 
EIF2B5CACH | CLE | EIF-2B | EIF2Bepsilon | LVWMeukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDaReconstituted ComplexBioGRID10858531 
-HPRD10805739 
NDUFB8ASHI | CI-ASHINADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDaTwo-hybridBioGRID16169070 
STC2STC-2 | STCRPstanniocalcin 2Two-hybridBioGRID16169070 
 


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