Gene Page: KYNU

Summary
GeneID  8942
Symbol  KYNU
Synonyms  -
Description  kynureninase (L-kynurenine hydrolase)
See related  HGNC:6469|MIM:605197|Ensembl:ENSG00000115919|HPRD:08940|
Locus tag  -
Gene type  protein-coding
Map location  2q22.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.023 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.02395 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PERP0.600.56
LASS10.570.58
NOTCH40.550.57
TENC10.540.64
KCNJ140.540.51
SSH30.540.57
SPATA200.530.46
ZBTB7B0.530.46
GPR40.530.44
ARSA0.520.50
Top 10 negatively co-expressed genes
RPL9-0.38-0.48
LYPLAL1-0.37-0.43
RWDD1-0.37-0.43
SUB1-0.36-0.39
RNASEH2B-0.35-0.39
AC090186.1-0.35-0.36
DTWD1-0.35-0.41
PSMA6-0.34-0.42
VRK2-0.34-0.35
C11orf51-0.34-0.36
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0016787hydrolase activityIEA-
GO:0042803protein homodimerization activityIDA11985583 
GO:0030170pyridoxal phosphate bindingIEA-
GO:0030429kynureninase activityEXP9180257 
GO:0030429kynureninase activityIDA9180257 |11985583 
GO:0030429kynureninase activityIEA-
GO:0030429kynureninase activityIMP17334708 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0009435NAD biosynthetic processIEA-
GO:0008152metabolic processIEA-
GO:0006569tryptophan catabolic processIEA-
GO:0006569tryptophan catabolic processIMP17334708 
GO:0034341response to interferon-gammaIDA9291104 
GO:0019805quinolinate biosynthetic processIDA9291104 
GO:0034516response to vitamin B6IMP1939450 
GO:0043420anthranilate metabolic processIDA11985583 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP9180257 
GO:0005829cytosolIDA6468727 
GO:0005625soluble fractionIDA11985583 
GO:0005737cytoplasmIEA-
GO:0005739mitochondrionIDA6468727 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_TRYPTOPHAN_METABOLISM 4033All SZGR genes in this pathway
REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES 200136All SZGR genes in this pathway
REACTOME_TRYPTOPHAN_CATABOLISM 119All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_WITH_LMP1_UP 408247All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
NEWMAN_ERCC6_TARGETS_UP 2618All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_UP 276165All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_2_UP 13983All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_2_UP 418263All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_UP 341197All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_UP 457269All SZGR genes in this pathway
SENESE_HDAC1_AND_HDAC2_TARGETS_UP 238144All SZGR genes in this pathway
SENESE_HDAC2_TARGETS_UP 11466All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
KIM_WT1_TARGETS_8HR_DN 12984All SZGR genes in this pathway
GRAHAM_NORMAL_QUIESCENT_VS_NORMAL_DIVIDING_UP 6647All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_CD4_UP 6446All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_DN 186107All SZGR genes in this pathway
MAHADEVAN_IMATINIB_RESISTANCE_UP 2315All SZGR genes in this pathway
ROVERSI_GLIOMA_COPY_NUMBER_DN 5437All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL 326213All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_BASAL 330217All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
LI_CISPLATIN_RESISTANCE_UP 2820All SZGR genes in this pathway
TSUNODA_CISPLATIN_RESISTANCE_DN 5138All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
WU_CELL_MIGRATION 184114All SZGR genes in this pathway
ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP 223140All SZGR genes in this pathway
LEE_LIVER_CANCER_CIPROFIBRATE_DN 6643All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_TGFA_DN 6544All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_E2F1_DN 6438All SZGR genes in this pathway
FRASOR_RESPONSE_TO_ESTRADIOL_DN 8252All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
SMITH_TERT_TARGETS_DN 8769All SZGR genes in this pathway
LEE_LIVER_CANCER_MYC_DN 6340All SZGR genes in this pathway
LEE_LIVER_CANCER_E2F1_DN 6442All SZGR genes in this pathway
HSIAO_LIVER_SPECIFIC_GENES 244154All SZGR genes in this pathway
LENAOUR_DENDRITIC_CELL_MATURATION_DN 12890All SZGR genes in this pathway
ALCALAY_AML_BY_NPM1_LOCALIZATION_DN 184132All SZGR genes in this pathway
SUZUKI_RESPONSE_TO_TSA_AND_DECITABINE_1A 2316All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_DN 371218All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_UP 244151All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_DN 245144All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_SCC_UP 12375All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_UP 253147All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_UP 282183All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_DN 154101All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_DN 540340All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
SMID_BREAST_CANCER_ERBB2_UP 14783All SZGR genes in this pathway
IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_UP 12692All SZGR genes in this pathway
BERNARD_PPAPDC1B_TARGETS_UP 4020All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
BHATI_G2M_ARREST_BY_2METHOXYESTRADIOL_UP 12568All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_A 6752All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP 338225All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_UP 418282All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
TAVAZOIE_METASTASIS 10868All SZGR genes in this pathway
VALK_AML_CLUSTER_11 3624All SZGR genes in this pathway
JISON_SICKLE_CELL_DISEASE_UP 181106All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
DORN_ADENOVIRUS_INFECTION_12HR_DN 3325All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_UP 7646All SZGR genes in this pathway
KAMMINGA_SENESCENCE 4126All SZGR genes in this pathway
BAE_BRCA1_TARGETS_UP 7547All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_DN 222147All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_MESENCHYMAL 216130All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_6HR_DN 9156All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
ACOSTA_PROLIFERATION_INDEPENDENT_MYC_TARGETS_DN 11674All SZGR genes in this pathway
BHAT_ESR1_TARGETS_NOT_VIA_AKT1_DN 8861All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_PARTIAL 160106All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_DN 428246All SZGR genes in this pathway
GHANDHI_DIRECT_IRRADIATION_UP 11068All SZGR genes in this pathway
GHANDHI_BYSTANDER_IRRADIATION_UP 8654All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
FARMER_BREAST_CANCER_CLUSTER_3 1612All SZGR genes in this pathway


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