Gene Page: DOK2

Summary
GeneID  9046
Symbol  DOK2
Synonyms  p56DOK|p56dok-2
Description  docking protein 2, 56kDa
See related  HGNC:2991|MIM:604997|Ensembl:ENSG00000147443|HPRD:05411|
Locus tag  -
Gene type  protein-coding
Map location  8p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.031 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.03086 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.00057 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MICAL10.950.92
ADAMTS100.940.89
IGDCC30.930.85
AC145098.20.930.94
LMBR1L0.920.94
PLSCR30.920.88
UCKL10.920.89
FBN30.920.88
C19orf570.910.91
KIAA0895L0.910.94
Top 10 negatively co-expressed genes
FBXO2-0.66-0.64
HLA-F-0.66-0.74
AIFM3-0.66-0.73
ALDOC-0.65-0.69
C5orf53-0.64-0.74
LDHD-0.64-0.62
CLU-0.64-0.69
PTH1R-0.63-0.66
S100B-0.63-0.80
ABCG2-0.63-0.68
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005158insulin receptor bindingIEA-
GO:0005069transmembrane receptor protein tyrosine kinase docking protein activityIEA-
GO:0042802identical protein bindingIPI17353931 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayIEA-
GO:0007265Ras protein signal transductionIEA-
GO:0007166cell surface receptor linked signal transductionTAS10799545 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ASF1BCIA-II | FLJ10604ASF1 anti-silencing function 1 homolog B (S. cerevisiae)Affinity Capture-MSBioGRID17353931 
CFLARCASH | CASP8AP1 | CLARP | Casper | FLAME | FLAME-1 | FLAME1 | FLIP | I-FLICE | MRIT | c-FLIP | c-FLIPL | c-FLIPR | c-FLIPSCASP8 and FADD-like apoptosis regulatorAffinity Capture-MSBioGRID17353931 
DNAJB11ABBP-2 | ABBP2 | DJ9 | EDJ | ERdj3 | ERj3 | HEDJ | PRO1080 | UNQ537 | hDj9DnaJ (Hsp40) homolog, subfamily B, member 11Affinity Capture-MSBioGRID17353931 
DOK1MGC117395 | MGC138860 | P62DOKdocking protein 1, 62kDa (downstream of tyrosine kinase 1)Affinity Capture-WesternBioGRID10822173 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD,BioGRID10508618 
HSPA4LAPG-1 | Osp94heat shock 70kDa protein 4-likeAffinity Capture-MSBioGRID17353931 
INPP5DMGC104855 | MGC142140 | MGC142142 | SHIP | SHIP1 | SIP-145 | hp51CNinositol polyphosphate-5-phosphatase, 145kDaSHIP1 interacts with Dok2BIND10822173 
Affinity Capture-WesternBioGRID10822173 
KIAA1279DKFZp586B0923 | KBP | TTC20KIAA1279Two-hybridBioGRID16189514 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD10799545 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1-HPRD,BioGRID11689432 
PSMD10dJ889N15.2 | p28proteasome (prosome, macropain) 26S subunit, non-ATPase, 10Affinity Capture-MSBioGRID17353931 
RAB10-RAB10, member RAS oncogene familyAffinity Capture-MSBioGRID17353931 
RASA1CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAPRAS p21 protein activator (GTPase activating protein) 1Affinity Capture-WesternBioGRID10822173 
Dok2 interacts with RASGAPBIND10822173 
-HPRD10508618 |10799545 
RETCDHF12 | HSCR1 | MEN2A | MEN2B | MTC1 | PTC | RET-ELE1 | RET51ret proto-oncogene-HPRD,BioGRID11470823 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1Affinity Capture-WesternBioGRID10822173 
SPOPTEF2speckle-type POZ proteinAffinity Capture-MSBioGRID17353931 
SSSCA1p27Sjogren syndrome/scleroderma autoantigen 1Affinity Capture-MSBioGRID17353931 
TEKCD202B | TIE-2 | TIE2 | VMCM | VMCM1TEK tyrosine kinase, endothelial-HPRD,BioGRID9764820 
 


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