Gene Page: PSTPIP1

Summary ?
GeneID9051
SymbolPSTPIP1
SynonymsCD2BP1|CD2BP1L|CD2BP1S|H-PIP|PAPAS|PSTPIP
Descriptionproline-serine-threonine phosphatase interacting protein 1
ReferenceMIM:606347|HGNC:HGNC:9580|Ensembl:ENSG00000140368|HPRD:05891|Vega:OTTHUMG00000172594
Gene typeprotein-coding
Map location15q24.3
Pascal p-value0.823
Sherlock p-value0.004
Fetal beta-0.329
eGeneCaudate basal ganglia
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs2044453chr1577423512PSTPIP190510.18cis
rs17384809chr1577622005PSTPIP190510.02cis
rs12912084chr1577697702PSTPIP190510.04cis
rs17471480chr1577755549PSTPIP190510.05cis
rs4886874chr1577838085PSTPIP190510.02cis
rs7747217chr63576943PSTPIP190510trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ARHGEF70.920.93
UBN10.910.92
LARP4B0.910.92
MGAT50.900.92
KPNA60.900.91
ADAR0.890.91
ATRN0.890.90
SMCR80.890.90
KIAA14090.890.91
CEP680.880.91
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.69-0.73
FXYD1-0.69-0.73
MT-CO2-0.68-0.73
AF347015.21-0.68-0.76
HIGD1B-0.68-0.74
HSD17B14-0.66-0.69
AF347015.8-0.66-0.71
CST3-0.66-0.72
MT-CYB-0.65-0.68
AF347015.33-0.65-0.67

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003824catalytic activityIEA-
GO:0003779actin bindingIEA-
GO:0005515protein bindingIPI17353931 
GO:0019903protein phosphatase bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007155cell adhesionTAS9857189 
GO:0007165signal transductionTAS9857189 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042995cell projectionIEAaxon (GO term level: 4)-
GO:0001725stress fiberIEA-
GO:0005826contractile ringIEA-
GO:0005856cytoskeletonIEA-
GO:0005737cytoplasmIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD,BioGRID11163214 
ATICAICAR | AICARFT | FLJ93545 | IMPCHASE | PURH5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolaseAffinity Capture-MSBioGRID17353931 
BZW1BZAP45 | KIAA0005 | Nbla10236basic leucine zipper and W2 domains 1Affinity Capture-MSBioGRID17353931 
BZW2HSPC028 | MST017 | MSTP017basic leucine zipper and W2 domains 2Affinity Capture-MSBioGRID17353931 
CD2SRBC | T11CD2 molecule-HPRD,BioGRID9857189 
DDX21DKFZp686F21172 | GUA | GURDB | RH-II/GU | RH-II/GuADEAD (Asp-Glu-Ala-Asp) box polypeptide 21Affinity Capture-MSBioGRID17353931 
FDFT1DGPT | ERG9 | SQS | SSfarnesyl-diphosphate farnesyltransferase 1Affinity Capture-MSBioGRID17353931 
PTPN12PTP-PEST | PTPG1protein tyrosine phosphatase, non-receptor type 12-HPRD,BioGRID9422760 |11971877 
PTPN18BDP1 | PTP-HSCFprotein tyrosine phosphatase, non-receptor type 18 (brain-derived)Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID9265651 
RPL18A-ribosomal protein L18aAffinity Capture-MSBioGRID17353931 
RPL21DKFZp686C06101 | FLJ27458 | L21 | MGC104274 | MGC104275 | MGC71252ribosomal protein L21Affinity Capture-MSBioGRID17353931 
RPL23AFLJ27455 | MDA20ribosomal protein L23aAffinity Capture-MSBioGRID17353931 
RPL26-ribosomal protein L26Affinity Capture-MSBioGRID17353931 
RPL29HIP | HUMRPL29 | MGC88589ribosomal protein L29Affinity Capture-MSBioGRID17353931 
RPL3MGC104284 | TARBP-Bribosomal protein L3Affinity Capture-MSBioGRID17353931 
RPL31MGC88191ribosomal protein L31Affinity Capture-MSBioGRID17353931 
RPL32PP9932ribosomal protein L32Affinity Capture-MSBioGRID17353931 
RPL34MGC111005ribosomal protein L34Affinity Capture-MSBioGRID17353931 
RPL35-ribosomal protein L35Affinity Capture-MSBioGRID17353931 
RPL35A-ribosomal protein L35aAffinity Capture-MSBioGRID17353931 
RPL36DKFZp566B023ribosomal protein L36Affinity Capture-MSBioGRID17353931 
RPL36AL44L | MGC72020 | MIG6 | RPL44ribosomal protein L36aAffinity Capture-MSBioGRID17353931 
RPL37AMGC74786ribosomal protein L37aAffinity Capture-MSBioGRID17353931 
RUVBL1ECP54 | INO80H | NMP238 | PONTIN | Pontin52 | RVB1 | TIH1 | TIP49 | TIP49ARuvB-like 1 (E. coli)Affinity Capture-MSBioGRID17353931 
WASIMD2 | THC | WASPWiskott-Aldrich syndrome (eczema-thrombocytopenia)-HPRD,BioGRID9488710 
WASIMD2 | THC | WASPWiskott-Aldrich syndrome (eczema-thrombocytopenia)PSTPIP1 interacts with WASP.BIND11313252 
WASF1FLJ31482 | KIAA0269 | SCAR1 | WAVE | WAVE1WAS protein family, member 1-HPRD9804817 
WASF2SCAR2 | WAVE2 | dJ393P12.2WAS protein family, member 2-HPRD9804817 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NOD LIKE RECEPTOR SIGNALING PATHWAY 6247All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279178All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME THE NLRP3 INFLAMMASOME 129All SZGR 2.0 genes in this pathway
REACTOME INFLAMMASOMES 1712All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS 4633All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579346All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE DN 384220All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA DN 284156All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN 14295All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF DN 11878All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
DUNNE TARGETS OF AML1 MTG8 FUSION UP 5232All SZGR 2.0 genes in this pathway
ALCALA APOPTOSIS 8860All SZGR 2.0 genes in this pathway
FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE UP 16792All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953554All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783442All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN 373196All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR UP 430288All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP 259185All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN 315201All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418282All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408276All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP 288168All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 LCP WITH H3K4ME3 16280All SZGR 2.0 genes in this pathway
MIKKELSEN IPS LCP WITH H3K4ME3 174100All SZGR 2.0 genes in this pathway
MIKKELSEN ES LCP WITH H3K4ME3 14280All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway