Gene Page: HTR3B

Summary ?
GeneID9177
SymbolHTR3B
Synonyms5-HT3B
Description5-hydroxytryptamine receptor 3B
ReferenceMIM:604654|HGNC:HGNC:5298|Ensembl:ENSG00000149305|HPRD:06875|Vega:OTTHUMG00000168210
Gene typeprotein-coding
Map location11q23.1
Pascal p-value0.111
Fetal beta-0.932
SupportLIGAND GATED ION SIGNALING

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.006 
ExpressionMeta-analysis of gene expressionP value: 1.521 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 6 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SCNN1D0.820.84
C16orf790.760.78
CPT1B0.760.79
DOM3Z0.750.77
AP1G20.750.83
PILRB0.750.79
LIME10.750.76
HSF40.750.79
NOXA10.750.78
MAN2C10.740.77
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ABCD2-0.37-0.33
GMFB-0.35-0.31
PNPLA8-0.35-0.34
LMBRD2-0.35-0.29
TTC33-0.33-0.29
HSPA13-0.33-0.25
RAB30-0.33-0.25
MOBKL3-0.32-0.28
RLIM-0.32-0.25
AGPS-0.32-0.27

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0030594neurotransmitter receptor activityIEANeurotransmitter (GO term level: 5)-
GO:0005232serotonin-activated cation-selective channel activityTASserotonin (GO term level: 11)9950429 
GO:0004993serotonin receptor activityTASserotonin, Neurotransmitter (GO term level: 8)9950429 
GO:0005216ion channel activityTAS9950429 
GO:0005230extracellular ligand-gated ion channel activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)9950429 
GO:0007210serotonin receptor signaling pathwayIEAserotonin (GO term level: 8)-
GO:0006811ion transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS9950429 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413270All SZGR 2.0 genes in this pathway
REACTOME ION CHANNEL TRANSPORT 5542All SZGR 2.0 genes in this pathway
REACTOME LIGAND GATED ION CHANNEL TRANSPORT 2121All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 12HR DN 5745All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS UP 10264All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A DN 10868All SZGR 2.0 genes in this pathway
MIKKELSEN MEF LCP WITH H3K27ME3 7035All SZGR 2.0 genes in this pathway
MIKKELSEN ES LCP WITH H3K27ME3 148All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway