Gene Page: DEDD

Summary
GeneID  9191
Symbol  DEDD
Synonyms  CASP8IP1|DEDD1|DEFT|FLDED1|KE05
Description  death effector domain containing
See related  HGNC:2755|MIM:606841|Ensembl:ENSG00000158796|HPRD:06022|
Locus tag  -
Gene type  protein-coding
Map location  1q23.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
WDR700.960.93
GART0.960.93
PRPSAP20.950.94
WTAP0.950.95
ZSCAN210.950.91
TRA2A0.940.94
DDX50.940.95
CNOT20.940.92
SSRP10.940.92
TRAFD10.940.92
Top 10 negatively co-expressed genes
AF347015.27-0.78-0.89
AF347015.31-0.78-0.88
MT-CO2-0.77-0.88
AF347015.33-0.76-0.87
HLA-F-0.76-0.78
MT-CYB-0.76-0.87
AIFM3-0.75-0.78
AF347015.8-0.74-0.88
IFI27-0.73-0.84
AF347015.15-0.73-0.86
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingISS-
GO:0005515protein bindingIPI15688372 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0008625induction of apoptosis via death domain receptorsTAS9774341 
GO:0007283spermatogenesisTAS9832420 
GO:0006917induction of apoptosisISS-
GO:0042981regulation of apoptosisIEA-
GO:0016481negative regulation of transcriptionISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005730nucleolusISS-
GO:0005737cytoplasmISS-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CASP10ALPS2 | FLICE2 | MCH4caspase 10, apoptosis-related cysteine peptidase-HPRD,BioGRID12527898 
CASP3CPP32 | CPP32B | SCA-1caspase 3, apoptosis-related cysteine peptidase-HPRD12235123 
CASP8ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473caspase 8, apoptosis-related cysteine peptidase-HPRD,BioGRID12527898 
CCDC59BR22 | DKFZp686K1021 | FLJ10294 | HSPC128 | TAP26coiled-coil domain containing 59Affinity Capture-MSBioGRID17353931 
CFLARCASH | CASP8AP1 | CLARP | Casper | FLAME | FLAME-1 | FLAME1 | FLIP | I-FLICE | MRIT | c-FLIP | c-FLIPL | c-FLIPR | c-FLIPSCASP8 and FADD-like apoptosis regulator-HPRD,BioGRID11741985 
DEDDCASP8IP1 | DEDD1 | DEFT | FLDED1 | KE05death effector domain containingAffinity Capture-Western
Reconstituted Complex		BioGRID11965497 |12527898 
DEDD2FLAME-3death effector domain containing 2-HPRD,BioGRID11965497 |12527898 
FADDGIG3 | MGC8528 | MORT1Fas (TNFRSF6)-associated via death domain-HPRD,BioGRID9774341 
GTF3C3TFIIIC102 | TFIIICgamma | TFiiiC2-102general transcription factor IIIC, polypeptide 3, 102kDaAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID11965497 
KHK-ketohexokinase (fructokinase)Affinity Capture-MSBioGRID17353931 
KRT18CYK18 | K18keratin 18-HPRD,BioGRID12235123 
RANBP3DKFZp586I1520RAN binding protein 3Affinity Capture-MSBioGRID17353931 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-132/2122531m8hsa-miR-212SZUAACAGUCUCCAGUCACGGCC
hsa-miR-132brainUAACAGUCUACAGCCAUGGUCG
miR-148/1529489551A,m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-15/16/195/424/49711121118m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-17-5p/20/93.mr/106/519.d961967m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-188305311m8hsa-miR-188CAUCCCUUGCAUGGUGGAGGGU
miR-4956874m8hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-9395401m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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