Gene Page: PTTG1

Summary
GeneID  9232
Symbol  PTTG1
Synonyms  EAP1|HPTTG|MGC126883|MGC138276|PTTG|TUTR1
Description  pituitary tumor-transforming 1
See related  HGNC:9690|MIM:604147|Ensembl:ENSG00000164611|HPRD:04998|
Locus tag  -
Gene type  protein-coding
Map location  5q35.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0032 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01718 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00459 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PRCP0.740.66
SRI0.730.63
SNX50.720.70
RP4-604K5.10.720.65
C1orf570.710.60
SAR1B0.710.64
TMEM1650.700.61
NUDT60.700.58
PSPH0.690.58
CRYL10.690.57
Top 10 negatively co-expressed genes
HIVEP3-0.38-0.32
JAG2-0.36-0.33
SLC26A1-0.35-0.35
DMPK-0.35-0.35
CACNA1B-0.35-0.27
NBEAL2-0.34-0.38
CSMD2-0.34-0.26
CACNA1C-0.33-0.26
BAT2D1-0.33-0.29
PCDH24-0.33-0.24
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004869cysteine protease inhibitor activityNAS12194817 
GO:0003674molecular_functionND-
GO:0003700transcription factor activityTAS9811450 
GO:0005515protein bindingIPI12194817 
GO:0017124SH3 domain bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006366transcription from RNA polymerase II promoterTAS9811450 
GO:0007283spermatogenesisTAS9915854 
GO:0006281DNA repairIEA-
GO:0006259DNA metabolic processIEA-
GO:0007049cell cycleIEA-
GO:0007067mitosisIEA-
GO:0007059chromosome segregationIEA-
GO:0051276chromosome organizationIEA-
GO:0051301cell divisionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP12070128 
GO:0005575cellular_componentND-
GO:0005634nucleusIEA-
GO:0005634nucleusTAS9811450 
GO:0005737cytoplasmIEA-
GO:0005737cytoplasmTAS9811450 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CDC20CDC20A | MGC102824 | bA276H19.3 | p55CDCcell division cycle 20 homolog (S. cerevisiae)-HPRD11553328 
Securin interacts with Cdc20. This interaction was modelled on a demonstrated interaction between human Securin and Xenopus Cdc20.BIND15916961 
DNAJA1DJ-2 | DjA1 | HDJ2 | HSDJ | HSJ2 | HSPF4 | hDJ-2DnaJ (Hsp40) homolog, subfamily A, member 1-HPRD,BioGRID9915854 
ESPL1ESP1 | FLJ46492 | KIAA0165 | SEPARASE | SEPARINextra spindle pole bodies homolog 1 (S. cerevisiae)Separase interacts with Securin.BIND15989971 
ESPL1 (separase) interacts with PTTG1 (securin).BIND15880121 
PTTG1IPC21orf1 | C21orf3 | PBFpituitary tumor-transforming 1 interacting protein-HPRD,BioGRID10781616 
RPS10MGC88819ribosomal protein S10-HPRD,BioGRID9915854 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD,BioGRID12355087 
p53 interacts with securin.BIND12355087 
XRCC6CTC75 | CTCBF | G22P1 | KU70 | ML8 | TLAAX-ray repair complementing defective repair in Chinese hamster cells 6-HPRD,BioGRID11238996 
 


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