Gene Page: RPS6KA5

Summary
GeneID  9252
Symbol  RPS6KA5
Synonyms  MGC1911|MSK1|MSPK1|RLPK
Description  ribosomal protein S6 kinase, 90kDa, polypeptide 5
See related  HGNC:10434|MIM:603607|Ensembl:ENSG00000100784|HPRD:06789|
Locus tag  -
Gene type  protein-coding
Map location  14q31-q32.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.996 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIEA-
GO:0003824catalytic activityIEA-
GO:0005515protein bindingIPI12628924 
GO:0005524ATP bindingIDA9687510 
GO:0005524ATP bindingIEA-
GO:0004674protein serine/threonine kinase activityEXP9687510 
GO:0004674protein serine/threonine kinase activityIDA9687510 
GO:0004674protein serine/threonine kinase activityIEA-
GO:0016740transferase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0008237metallopeptidase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIDA9687510 
GO:0007173epidermal growth factor receptor signaling pathwayTAS9873047 
GO:0006468protein amino acid phosphorylationIEA-
GO:0006508proteolysisIEA-
GO:0007243protein kinase cascadeIDA9687510 
GO:0006950response to stressIEP9873047 
GO:0009605response to external stimulusIEP9873047 
GO:0042221response to chemical stimulusIEP9873047 
GO:0016572histone phosphorylationIDA9873047 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA9687510 
GO:0005654nucleoplasmEXP9687510 
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BADBBC2 | BCL2L8BCL2-associated agonist of cell deathReconstituted ComplexBioGRID11500364 
CREB1CREB | MGC9284cAMP responsive element binding protein 1Biochemical Activity
Reconstituted Complex		BioGRID9687510 |11500364 
EGFHOMG4 | URGepidermal growth factor (beta-urogastrone)Phenotypic EnhancementBioGRID9687510 
MAPK1ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapkmitogen-activated protein kinase 1Phenotypic EnhancementBioGRID9687510 
MAPK11P38B | P38BETA2 | PRKM11 | SAPK2 | SAPK2B | p38-2 | p38Betamitogen-activated protein kinase 11Phenotypic EnhancementBioGRID9687510 
MAPK14CSBP1 | CSBP2 | CSPB1 | EXIP | Mxi2 | PRKM14 | PRKM15 | RK | SAPK2A | p38 | p38ALPHAmitogen-activated protein kinase 14Affinity Capture-WesternBioGRID11157753 
PLA2G4AMGC126350 | PLA2G4 | cPLA2-alphaphospholipase A2, group IVA (cytosolic, calcium-dependent)An unspecified isoform of MSK1 phosphorylates cPLA2.BIND10978317 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-103/107120912151Ahsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-128990996m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-142-5p7507571A,m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-148/152792798m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-17-5p/20/93.mr/106/519.d11331139m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-1991631691Ahsa-miR-199aCCCAGUGUUCAGACUACCUGUUC
hsa-miR-199bCCCAGUGUUUAGACUAUCUGUUC
miR-204/2119519581A,m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-271811881A,m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-493-5p10371043m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-93.hd/291-3p/294/295/302/372/373/52011321138m8hsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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