Gene Page: NUMBL

Summary
GeneID  9253
Symbol  NUMBL
Synonyms  CAG3A|CTG3a|NBL|NUMB-R|NUMBLIKE|NUMBR|TNRC23
Description  numb homolog (Drosophila)-like
See related  HGNC:8061|MIM:604018|Ensembl:ENSG00000105245|HPRD:04931|
Locus tag  -
Gene type  protein-coding
Map location  19q13.13-q13.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 4 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0329 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TGIF20.910.60
TP530.910.75
CDK20.910.67
GLI30.900.52
MCM20.900.85
PTBP10.890.72
TEAD20.890.63
CELSR10.890.68
ITPRIP0.880.57
SFRP10.880.73
Top 10 negatively co-expressed genes
C5orf53-0.43-0.71
HLA-F-0.42-0.71
FBXO2-0.42-0.61
PTH1R-0.42-0.70
LHPP-0.41-0.57
SLC16A11-0.41-0.65
ASPHD1-0.41-0.56
AIFM3-0.40-0.64
AF347015.27-0.40-0.76
AF347015.31-0.40-0.77
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI16713569 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007409axonogenesisIEAneuron, axon, neurite (GO term level: 12)-
GO:0007405neuroblast proliferationIEAneuron (GO term level: 8)-
GO:0030900forebrain developmentIEABrain (GO term level: 8)-
GO:0007399nervous system developmentTASneurite (GO term level: 5)9303539 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EPS15AF-1P | AF1P | MLLT5epidermal growth factor receptor pathway substrate 15The EH domain of Eps15 interacts with the NPF motif of NUMB-R. This interaction was modeled on a demonstrated interaction between mouse Eps15 and human NUMB-R.BIND9303539 
 
Pathway annotation
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/986266321Ahsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-125/3511901961Ahsa-miR-125bbrainUCCCUGAGACCCUAACUUGUGA
hsa-miR-125abrainUCCCUGAGACCCUUUAACCUGUG
miR-142-3p1431491Ahsa-miR-142-3pUGUAGUGUUUCCUACUUUAUGGA
miR-203.12212271Ahsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-2184484541Ahsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-34/449226232m8hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC
miR-369-3p7417481A,m8hsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-374742748m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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