Gene Page: ARHGEF6

Summary
GeneID  9459
Symbol  ARHGEF6
Synonyms  COOL2|Cool-2|KIAA0006|MRX46|PIXA|alpha-PIX|alphaPIX
Description  Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
See related  HGNC:685|MIM:300267|Ensembl:ENSG00000129675|HPRD:02226|
Locus tag  RP3-527F8.4
Gene type  protein-coding
Map location  Xq26.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0071 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MYO160.850.89
L3MBTL30.840.88
RP11-791G16.20.840.82
SRD5A10.820.88
RHOV0.820.87
STMN20.820.87
GPRIN10.820.90
AADAT0.820.80
IL27RA0.810.81
SCN9A0.810.88
Top 10 negatively co-expressed genes
HLA-F-0.66-0.76
AIFM3-0.64-0.73
TSC22D4-0.63-0.75
AF347015.27-0.63-0.79
AF347015.33-0.62-0.80
MT-CO2-0.62-0.81
AF347015.31-0.62-0.79
S100B-0.62-0.75
PTGDS-0.61-0.71
CSRP1-0.61-0.71
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005089Rho guanyl-nucleotide exchange factor activityNAS11017088 
GO:0005085guanyl-nucleotide exchange factor activityIEA-
GO:0005096GTPase activator activityNAS9582122 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007254JNK cascadeNAS11564864 
GO:0006915apoptosisNAS11564864 
GO:0035023regulation of Rho protein signal transductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIC11017088 
GO:0005737cytoplasmIDA18029348 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARHGEF7BETA-PIX | COOL1 | DKFZp686C12170 | DKFZp761K1021 | KIAA0142 | KIAA0412 | Nbla10314 | P50 | P50BP | P85 | P85COOL1 | P85SPR | PAK3 | PIXBRho guanine nucleotide exchange factor (GEF) 7ARHGEF6 interacts with ARHGEF7BIND12499396 
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)ARHGEF6 (Cool-2) interacts with Cdc42.BIND15649357 
GIT1-G protein-coupled receptor kinase interacting ArfGAP 1-HPRD10896954 
Affinity Capture-WesternBioGRID10428811 
PAK1MGC130000 | MGC130001 | PAKalphap21 protein (Cdc42/Rac)-activated kinase 1-HPRD,BioGRID9659915 
PAK3CDKN1A | MRX30 | MRX47 | OPHN3 | PAK3beta | bPAK | hPAK3p21 protein (Cdc42/Rac)-activated kinase 3-HPRD,BioGRID9659915 
PARVBCGI-56parvin, betaARHGEF6 interacts with PARVBBIND12499396 
-HPRD12499396 
PKLRPK1 | PKL | PKR | PKRL | RPKpyruvate kinase, liver and RBCAffinity Capture-WesternBioGRID12006652 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)ARHGEF6 (Cool-2) interacts with Rac1.BIND15649357 
TGFBR1AAT5 | ACVRLK4 | ALK-5 | ALK5 | LDS1A | LDS2A | SKR4 | TGFR-1transforming growth factor, beta receptor 1T-beta-RI interacts with alpha-PIX. This interaction was modeled on a demonstrated interaction between human T-beta-RI and mouse alpha-PIX.BIND15761153 
TGFBR2AAT3 | FAA3 | LDS1B | LDS2B | MFS2 | RIIC | TAAD2 | TGFR-2 | TGFbeta-RIItransforming growth factor, beta receptor II (70/80kDa)T-beta-RII interacts with alpha-PIX. This interaction was modeled on a demonstrated interaction between human T-beta-RII and mouse alpha-PIX.BIND15761153 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124/5062632m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-128511m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-13522522258m8hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-142-5p246924751Ahsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-30-5p229222991A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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