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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

Gene Ranking Integration

Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: SH3BP5

Summary

GeneID

9467

Symbol

SH3BP5

Synonyms

SAB

Description

SH3-domain binding protein 5 (BTK-associated)

Locus tag

Gene type

protein-coding

Map location

3p24.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.006

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.1061

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

MBD5

0.96

KIAA2026

0.94

0.95

GON4L

0.94

0.95

KIAA1409

0.94

INO80

0.94

0.95

KDM2A

0.94

0.95

ZNF318

0.94

0.95

NSD1

0.94

0.95

ZZEF1

0.94

TGFBRAP1

0.93

0.94

Top 10 negatively co-expressed genes

AF347015.31

-0.78

-0.83

MT-CO2

-0.75

-0.82

FXYD1

-0.75

-0.80

AF347015.27

-0.74

-0.79

HIGD1B

-0.74

-0.82

AF347015.21

-0.72

-0.86

MT-CYB

-0.72

-0.77

AF347015.33

-0.72

-0.75

IFI27

-0.72

-0.78

COPZ2

-0.72

-0.76

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005515

protein binding

IPI

9571151

GO:0004860

protein kinase inhibitor activity

IDA

10339589

GO:0017124

SH3 domain binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007242

intracellular signaling cascade

IDA

10339589

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005737

cytoplasm

TAS

9571151

GO:0005739

mitochondrion

IEA

Interactions

Shown by Network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BTK	AGMX1 \| AT \| ATK \| BPK \| IMD1 \| MGC126261 \| MGC126262 \| PSCTK1 \| XLA	Bruton agammaglobulinemia tyrosine kinase	-	HPRD,BioGRID	9571151
BTK		Bruton agammaglobulinemia tyrosine kinase	-	HPRD	9571151 \|10339589
MAPK10	FLJ12099 \| FLJ33785 \| JNK3 \| JNK3A \| MGC50974 \| PRKM10 \| p493F12 \| p54bSAPK	mitogen-activated protein kinase 10	Sab interacts with JNK3-alpha-1.	BIND	12167088
			Sab interacts with JNK3-alpha-2.	BIND	12167088
			-	HPRD,BioGRID	12167088
MAPK8	JNK \| JNK1 \| JNK1A2 \| JNK21B1/2 \| PRKM8 \| SAPK1	mitogen-activated protein kinase 8	Sab interacts with JNK1-alpha-2.	BIND	12167088
			Sab interacts with JNK1-alpha-1.	BIND	12167088
			-	HPRD,BioGRID	12167088
			Sab interacts with JNK1-beta-2.	BIND	12167088
			Sab interacts with JNK1-beta-1.	BIND	12167088
MAPK9	JNK-55 \| JNK2 \| JNK2A \| JNK2ALPHA \| JNK2B \| JNK2BETA \| PRKM9 \| SAPK \| p54a \| p54aSAPK	mitogen-activated protein kinase 9	-	HPRD,BioGRID	12167088
			Sab interacts with JNK2-alpha-2.	BIND	12167088
			Sab interacts with JNK2-alpha-1.	BIND	12167088
			Sab interacts with JNK2-beta-2.	BIND	12167088
			Sab interacts with JNK2-beta-1.	BIND	12167088

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-103/107	871	878	1A,m8	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	871	878	1A,m8	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-137	264	271	1A,m8	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-17-5p/20/93.mr/106/519.d	622	628	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-335	167	173	m8	hsa-miR-335^brain	UCAAGAGCAAUAACGAAAAAUGU
miR-539	821	827	m8	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU
miR-96	61	67	m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.