Summary ?
GeneID9481
SymbolSLC25A27
SynonymsUCP4
Descriptionsolute carrier family 25 member 27
ReferenceMIM:613725|HGNC:HGNC:21065|Ensembl:ENSG00000153291|HPRD:15358|Vega:OTTHUMG00000014786
Gene typeprotein-coding
Map location6p12.3
Pascal p-value0.093
Sherlock p-value0.695
Fetal beta-0.531
eGeneAnterior cingulate cortex BA24
Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Hippocampus
Hypothalamus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.04433 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs12192544chr646620251SLC25A2794810.06cis
rs17222843chr10109445830SLC25A2794810.09trans
rs952884646613083SLC25A27ENSG00000153291.113.192E-70-7595gtex_brain_ba24
rs61136694646618415SLC25A27ENSG00000153291.114.77E-80-2263gtex_brain_ba24
rs13204743646618456SLC25A27ENSG00000153291.118.939E-70-2222gtex_brain_ba24
rs9349370646619476SLC25A27ENSG00000153291.114.344E-90-1202gtex_brain_ba24
rs12192544646620252SLC25A27ENSG00000153291.111.068E-80-426gtex_brain_ba24
rs8427646621097SLC25A27ENSG00000153291.115.516E-90419gtex_brain_ba24
rs6900238646624020SLC25A27ENSG00000153291.114.205E-903342gtex_brain_ba24
rs6900121646624079SLC25A27ENSG00000153291.111.122E-803401gtex_brain_ba24
rs7739815646624656SLC25A27ENSG00000153291.111.354E-1103978gtex_brain_ba24
rs9381468646625274SLC25A27ENSG00000153291.115.471E-904596gtex_brain_ba24
rs10807344646625635SLC25A27ENSG00000153291.111.257E-804957gtex_brain_ba24
rs6907892646625886SLC25A27ENSG00000153291.116.652E-705208gtex_brain_ba24
rs953062646626353SLC25A27ENSG00000153291.116.652E-705675gtex_brain_ba24
rs3778483646627100SLC25A27ENSG00000153291.118.215E-706422gtex_brain_ba24
rs4144937646628516SLC25A27ENSG00000153291.118.215E-707838gtex_brain_ba24
rs9296504646629505SLC25A27ENSG00000153291.118.215E-708827gtex_brain_ba24
rs9296505646629841SLC25A27ENSG00000153291.118.215E-709163gtex_brain_ba24
rs9381469646630068SLC25A27ENSG00000153291.118.215E-709390gtex_brain_ba24
rs6901132646631801SLC25A27ENSG00000153291.116.662E-7011123gtex_brain_ba24
rs7753137646635846SLC25A27ENSG00000153291.111.931E-8015168gtex_brain_ba24
rs9472817646640992SLC25A27ENSG00000153291.114.216E-9020314gtex_brain_ba24
rs2270450646644875SLC25A27ENSG00000153291.111.357E-11024197gtex_brain_ba24
rs34964632646648129SLC25A27ENSG00000153291.111.357E-11027451gtex_brain_ba24
rs397812173646651472SLC25A27ENSG00000153291.116.652E-7030794gtex_brain_ba24
rs10948299646653858SLC25A27ENSG00000153291.112.725E-6033180gtex_brain_ba24
rs13196132646655603SLC25A27ENSG00000153291.115.27E-7034925gtex_brain_ba24
rs9381472646658905SLC25A27ENSG00000153291.115.557E-7038227gtex_brain_ba24
rs974670646667343SLC25A27ENSG00000153291.112.403E-6046665gtex_brain_ba24
rs12528857646669936SLC25A27ENSG00000153291.111.257E-8049258gtex_brain_ba24
rs370368833646672452SLC25A27ENSG00000153291.112.438E-6051774gtex_brain_ba24
rs2216465646676019SLC25A27ENSG00000153291.115.549E-7055341gtex_brain_ba24
rs4498351646676783SLC25A27ENSG00000153291.112.392E-9056105gtex_brain_ba24
rs6899519646681900SLC25A27ENSG00000153291.116.518E-13061222gtex_brain_ba24
rs41361844646683978SLC25A27ENSG00000153291.111.366E-9063300gtex_brain_ba24
rs1805017646684222SLC25A27ENSG00000153291.116.518E-13063544gtex_brain_ba24
rs12195701646687419SLC25A27ENSG00000153291.111.478E-9066741gtex_brain_ba24
rs9472831646689847SLC25A27ENSG00000153291.111.366E-9069169gtex_brain_ba24
rs34405250646695911SLC25A27ENSG00000153291.118.43E-8075233gtex_brain_ba24
rs10948300646696342SLC25A27ENSG00000153291.119.032E-8075664gtex_brain_ba24
rs9381474646697380SLC25A27ENSG00000153291.111.002E-7076702gtex_brain_ba24
rs9381475646699292SLC25A27ENSG00000153291.111.001E-7078614gtex_brain_ba24
rs9296509646701037SLC25A27ENSG00000153291.111.015E-6080359gtex_brain_ba24
rs9381476646701733SLC25A27ENSG00000153291.111.015E-6081055gtex_brain_ba24
rs9395208646703319SLC25A27ENSG00000153291.111.015E-6082641gtex_brain_ba24
rs13210554646704339SLC25A27ENSG00000153291.111.015E-6083661gtex_brain_ba24
rs10948301646704467SLC25A27ENSG00000153291.111.015E-6083789gtex_brain_ba24
rs1421379646705994SLC25A27ENSG00000153291.111.015E-6085316gtex_brain_ba24
rs1421380646706271SLC25A27ENSG00000153291.111.015E-6085593gtex_brain_ba24
rs9349373646706593SLC25A27ENSG00000153291.111.015E-6085915gtex_brain_ba24
rs9369631646707519SLC25A27ENSG00000153291.111.015E-6086841gtex_brain_ba24
rs9381477646707580SLC25A27ENSG00000153291.111.015E-6086902gtex_brain_ba24
rs60331073646707818SLC25A27ENSG00000153291.119.483E-7087140gtex_brain_ba24
rs9395209646709014SLC25A27ENSG00000153291.111.015E-6088336gtex_brain_ba24
rs9381478646709021SLC25A27ENSG00000153291.111.015E-6088343gtex_brain_ba24
rs11962772646709601SLC25A27ENSG00000153291.111.015E-6088923gtex_brain_ba24
rs1862008646710279SLC25A27ENSG00000153291.111.015E-6089601gtex_brain_ba24
rs9395210646711962SLC25A27ENSG00000153291.111.015E-6091284gtex_brain_ba24
rs9369632646713394SLC25A27ENSG00000153291.111.438E-6092716gtex_brain_ba24
rs9296510646713805SLC25A27ENSG00000153291.119.19E-7093127gtex_brain_ba24
rs9367255646714466SLC25A27ENSG00000153291.119.232E-7093788gtex_brain_ba24
rs9349374646714598SLC25A27ENSG00000153291.119.248E-7093920gtex_brain_ba24
rs1592704646715761SLC25A27ENSG00000153291.119.324E-7095083gtex_brain_ba24
rs1362932646716079SLC25A27ENSG00000153291.111.015E-6095401gtex_brain_ba24
rs200787031646717291SLC25A27ENSG00000153291.111.322E-6096613gtex_brain_ba24
rs9367256646723267SLC25A27ENSG00000153291.119.609E-70102589gtex_brain_ba24
rs9381480646724131SLC25A27ENSG00000153291.114.861E-70103453gtex_brain_ba24
rs12215229646614439SLC25A27ENSG00000153291.111.799E-70-6239gtex_brain_putamen_basal
rs61136694646618415SLC25A27ENSG00000153291.111.497E-60-2263gtex_brain_putamen_basal
rs13204743646618456SLC25A27ENSG00000153291.112.844E-70-2222gtex_brain_putamen_basal
rs9349370646619476SLC25A27ENSG00000153291.111.239E-60-1202gtex_brain_putamen_basal
rs12192544646620252SLC25A27ENSG00000153291.112.508E-80-426gtex_brain_putamen_basal
rs8427646621097SLC25A27ENSG00000153291.119.763E-70419gtex_brain_putamen_basal
rs6900238646624020SLC25A27ENSG00000153291.111.067E-603342gtex_brain_putamen_basal
rs7739815646624656SLC25A27ENSG00000153291.113.49E-1203978gtex_brain_putamen_basal
rs9381468646625274SLC25A27ENSG00000153291.119.711E-704596gtex_brain_putamen_basal
rs10807344646625635SLC25A27ENSG00000153291.112.51E-804957gtex_brain_putamen_basal
rs6907892646625886SLC25A27ENSG00000153291.114.261E-705208gtex_brain_putamen_basal
rs953062646626353SLC25A27ENSG00000153291.114.261E-705675gtex_brain_putamen_basal
rs6901132646631801SLC25A27ENSG00000153291.114.283E-7011123gtex_brain_putamen_basal
rs9472817646640992SLC25A27ENSG00000153291.111.071E-6020314gtex_brain_putamen_basal
rs2270450646644875SLC25A27ENSG00000153291.113.966E-12024197gtex_brain_putamen_basal
rs34964632646648129SLC25A27ENSG00000153291.113.966E-12027451gtex_brain_putamen_basal
rs397812173646651472SLC25A27ENSG00000153291.114.261E-7030794gtex_brain_putamen_basal
rs13196132646655603SLC25A27ENSG00000153291.112.394E-7034925gtex_brain_putamen_basal
rs9381472646658905SLC25A27ENSG00000153291.114.244E-7038227gtex_brain_putamen_basal
rs12528857646669936SLC25A27ENSG00000153291.112.51E-8049258gtex_brain_putamen_basal
rs2216465646676019SLC25A27ENSG00000153291.114.261E-7055341gtex_brain_putamen_basal
rs4498351646676783SLC25A27ENSG00000153291.111.698E-6056105gtex_brain_putamen_basal
rs6899519646681900SLC25A27ENSG00000153291.113.966E-12061222gtex_brain_putamen_basal
rs41361844646683978SLC25A27ENSG00000153291.111.879E-6063300gtex_brain_putamen_basal
rs1805017646684222SLC25A27ENSG00000153291.113.966E-12063544gtex_brain_putamen_basal
rs12195701646687419SLC25A27ENSG00000153291.112.574E-8066741gtex_brain_putamen_basal
rs9472831646689847SLC25A27ENSG00000153291.111.879E-6069169gtex_brain_putamen_basal
rs71716873646714134SLC25A27ENSG00000153291.113.299E-7093456gtex_brain_putamen_basal
rs200787031646717291SLC25A27ENSG00000153291.114.116E-7096613gtex_brain_putamen_basal
rs9367256646723267SLC25A27ENSG00000153291.111.33E-60102589gtex_brain_putamen_basal
rs9381480646724131SLC25A27ENSG00000153291.113.461E-70103453gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
LGI30.920.88
ABCA20.920.89
TPPP0.890.91
SEC14L50.890.90
ZFYVE280.880.88
ZBTB7A0.880.90
TNK20.880.87
SEPT80.880.87
KNDC10.870.82
KLHL210.870.75
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C9orf46-0.59-0.75
EXOSC8-0.56-0.68
GTF3C6-0.55-0.63
RPS18-0.55-0.73
AC008073.1-0.54-0.65
RPS23-0.54-0.72
RPL32-0.54-0.73
RPL24-0.54-0.74
RPS3AP47-0.54-0.71
RPL27-0.54-0.72

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005488bindingIEA-
GO:0005215transporter activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006839mitochondrial transportIEAglutamate (GO term level: 6)-
GO:0006091generation of precursor metabolites and energyTAS10025957 
GO:0006810transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005739mitochondrionIEA-
GO:0005739mitochondrionTAS10025957 
GO:0005743mitochondrial inner membraneIEA-
GO:0005743mitochondrial inner membraneNAS10025957 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BASAKI YBX1 TARGETS DN 384230All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL UP 316190All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537339All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769437All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648385All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN 264159All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G1 S 14776All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE S 16286All SZGR 2.0 genes in this pathway
GOBERT CORE OLIGODENDROCYTE DIFFERENTIATION 4028All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/988490m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-142-5p137143m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-17-5p/20/93.mr/106/519.d1351421A,m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-34/449140114081A,m8hsa-miR-34abrainUGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34cAGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449bAGGCAGUGUAUUGUUAGCUGGC