Gene Page: TCL1B
Summary ?
| GeneID | 9623 |
| Symbol | TCL1B |
| Synonyms | SYN-1|TML1 |
| Description | T-cell leukemia/lymphoma 1B |
| Reference | MIM:603769|HGNC:HGNC:11649|Ensembl:ENSG00000213231|HPRD:04795|Vega:OTTHUMG00000028912 |
| Gene type | protein-coding |
| Map location | 14q32.1 |
| Pascal p-value | 0.131 |
| DMG | 1 (# studies) |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg02171093 | 14 | 96152529 | TCL1B | 2.454E-4 | 0.342 | 0.037 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| STAG1 | 0.96 | 0.93 |
| PAK2 | 0.96 | 0.93 |
| NONO | 0.96 | 0.86 |
| XRN2 | 0.95 | 0.86 |
| TNPO1 | 0.95 | 0.92 |
| PBRM1 | 0.95 | 0.91 |
| FUBP1 | 0.95 | 0.87 |
| GNA13 | 0.95 | 0.90 |
| SLC39A6 | 0.95 | 0.91 |
| DHX9 | 0.95 | 0.88 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C5orf53 | -0.70 | -0.74 |
| PTH1R | -0.68 | -0.75 |
| TNFSF12 | -0.67 | -0.68 |
| SLC16A11 | -0.67 | -0.68 |
| HLA-F | -0.66 | -0.70 |
| AIFM3 | -0.66 | -0.70 |
| IFI27 | -0.66 | -0.82 |
| FXYD1 | -0.65 | -0.82 |
| AF347015.31 | -0.65 | -0.80 |
| AF347015.27 | -0.65 | -0.79 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| YORDY RECIPROCAL REGULATION BY ETS1 AND SP100 DN | 87 | 48 | All SZGR 2.0 genes in this pathway |
| HATADA METHYLATED IN LUNG CANCER DN | 38 | 13 | All SZGR 2.0 genes in this pathway |
| HADDAD B LYMPHOCYTE PROGENITOR | 293 | 193 | All SZGR 2.0 genes in this pathway |
| SU PANCREAS | 54 | 30 | All SZGR 2.0 genes in this pathway |
| SHEDDEN LUNG CANCER GOOD SURVIVAL A12 | 317 | 177 | All SZGR 2.0 genes in this pathway |