Gene Page

Gene Page: SNCAIP

Summary

GeneID

9627

Symbol

SNCAIP

Synonyms

MGC39814|SYPH1

Description

synuclein, alpha interacting protein

Locus tag

Gene type

protein-coding

Map location

5q23.1-q23.3

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 4

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

SORT1

0.93

0.86

ARAP2

0.93

0.81

TACC1

0.92

0.80

FAM73A

0.92

0.84

MBNL2

0.92

0.85

ENPP4

0.92

0.85

PRUNE2

0.91

0.80

ARFGEF2

0.89

0.82

PCDH9

0.89

0.82

ITPR1

0.89

0.86

Top 10 negatively co-expressed genes

BCL7C

-0.51

-0.62

AC006276.2

-0.50

-0.55

RPL35

-0.47

-0.61

TBC1D10A

-0.46

-0.37

RPL36

-0.46

-0.60

C9orf46

-0.45

-0.52

AC135586.1

-0.45

-0.55

NME4

-0.45

-0.55

RPLP1

-0.44

-0.54

RPL27

-0.44

-0.55

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005515

protein binding

IPI

11590439 |11956199 |12364339

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0046928

regulation of neurotransmitter secretion

IDA

Synap, Neurotransmitter (GO term level: 9)

14506261

GO:0042417

dopamine metabolic process

IDA

Neurotransmitter, dopamine (GO term level: 8)

14506261

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0043025

cell soma

NAS

axon, dendrite (GO term level: 4)

11956199

GO:0042734

presynaptic membrane

NAS

neuron, axon, Synap (GO term level: 5)

11956199

GO:0005634

nucleus

IDA

18029348

GO:0005730

nucleolus

IDA

18029348

GO:0005737

cytoplasm

IDA

14506261 |18029348

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
C7orf20	CEE \| CGI-20	chromosome 7 open reading frame 20	Two-hybrid	BioGRID	16169070
CSNK2B	CK2B \| CK2N \| CSK2B \| G5A \| MGC138222 \| MGC138224	casein kinase 2, beta polypeptide	CK2B interacts with Synphilin-1.	BIND	14645218
PARK2	AR-JP \| LPRS2 \| PDJ \| PRKN	Parkinson disease (autosomal recessive, juvenile) 2, parkin	-	HPRD,BioGRID	11590439
			Synphilin-1 is ubiquitinated by Parkin.	BIND	15105460
			Synphilin interacts with parkin.	BIND	15603737
PTN	HARP \| HBGF8 \| HBNF \| NEGF1	pleiotrophin	Two-hybrid	BioGRID	16169070
SEPT4	ARTS \| BRADEION \| CE5B3 \| H5 \| MART \| PNUTL2 \| SEP4 \| hCDCREL-2 \| hucep-7	septin 4	-	HPRD	12695511
SH2D3C	CHAT \| FLJ39664 \| NSP3 \| PRO34088	SH2 domain containing 3C	Two-hybrid	BioGRID	16169070
SNCA	MGC110988 \| NACP \| PARK1 \| PARK4 \| PD1	synuclein, alpha (non A4 component of amyloid precursor)	Affinity Capture-Western FRET Reconstituted Complex Two-hybrid	BioGRID	10319874 \|11331421 \|11742726 \|12044636
			SNCAIP interacts with SNCA.	BIND	10319874
			-	HPRD	10319874 \|11331421 \|12044636
UBB	FLJ25987 \| MGC8385	ubiquitin B	Synphilin-1 is ubiquitinated.	BIND	15105460

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	203	210	1A,m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	203	209	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	203	209	1A	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.