Gene Page: CROCC
Summary ?
| GeneID | 9696 |
| Symbol | CROCC |
| Synonyms | ROLT |
| Description | ciliary rootlet coiled-coil, rootletin |
| Reference | MIM:615776|HGNC:HGNC:21299|Ensembl:ENSG00000058453|HPRD:16758|Vega:OTTHUMG00000002200 |
| Gene type | protein-coding |
| Map location | 1p36.13 |
| Pascal p-value | 0.115 |
| Sherlock p-value | 0.129 |
| Fetal beta | 0.758 |
| DMG | 1 (# studies) |
| eGene | Cerebellar Hemisphere Cerebellum Frontal Cortex BA9 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg00053536 | 1 | 17291209 | CROCC | 3.33E-5 | 0.271 | 0.019 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| HTR3B | 0.89 | 0.81 |
| SNAP25 | 0.87 | 0.68 |
| CABP1 | 0.87 | 0.88 |
| SYT12 | 0.87 | 0.85 |
| VSNL1 | 0.86 | 0.70 |
| KCNK1 | 0.85 | 0.84 |
| APOL2 | 0.85 | 0.76 |
| AC103681.1 | 0.85 | 0.80 |
| ZNF365 | 0.85 | 0.70 |
| VIPR1 | 0.84 | 0.90 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| BCL7C | -0.51 | -0.74 |
| FADS2 | -0.49 | -0.66 |
| PKN1 | -0.48 | -0.72 |
| PDE9A | -0.48 | -0.75 |
| SH3BP2 | -0.46 | -0.74 |
| AC006276.2 | -0.46 | -0.54 |
| TUBB2B | -0.46 | -0.75 |
| TRAF4 | -0.45 | -0.73 |
| SH2B2 | -0.45 | -0.75 |
| KIAA1949 | -0.45 | -0.70 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005198 | structural molecule activity | ISS | - | |
| GO:0019894 | kinesin binding | ISS | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0030030 | cell projection organization | IEA | axon (GO term level: 7) | - |
| GO:0007049 | cell cycle | IEA | - | |
| GO:0051297 | centrosome organization | IDA | 16203858 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005814 | centriole | ISS | - | |
| GO:0035253 | ciliary rootlet | ISS | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN | 234 | 147 | All SZGR 2.0 genes in this pathway |
| PEREZ TP53 TARGETS | 1174 | 695 | All SZGR 2.0 genes in this pathway |
| SCHAEFFER PROSTATE DEVELOPMENT 48HR DN | 428 | 306 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 24HR DN | 148 | 102 | All SZGR 2.0 genes in this pathway |
| BOYLAN MULTIPLE MYELOMA C D UP | 139 | 95 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES ICP WITH H3K4ME3 | 718 | 401 | All SZGR 2.0 genes in this pathway |