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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: MAML1

Summary

GeneID

9794

Symbol

MAML1

Synonyms

KIAA0200|Mam-1|Mam1

Description

mastermind-like 1 (Drosophila)

Locus tag

Gene type

protein-coding

Map location

5q35

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_IIA

genome scan meta-analysis (All samples)

Psr: 0.0276

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

RASGRF2

0.85

0.76

DUSP27

0.85

0.81

TRHDE

0.85

0.73

CREG2

0.84

0.76

GRIN2A

0.84

0.78

C1orf183

0.84

0.79

LRRK1

0.84

0.78

RASGRP1

0.84

0.72

RPH3A

0.83

0.78

KCNB1

0.83

0.63

Top 10 negatively co-expressed genes

BCL7C

-0.46

-0.60

TRAF4

-0.44

-0.54

SH2D2A

-0.44

-0.51

SH3BP2

-0.43

-0.54

TUBB2B

-0.43

-0.50

SH2B2

-0.43

-0.52

HEBP2

-0.43

-0.62

KIAA1949

-0.43

-0.39

PDE9A

-0.42

-0.49

HYAL2

-0.42

-0.51

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003713

transcription coactivator activity

IDA

11101851

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006355

regulation of transcription, DNA-dependent

IEA

GO:0006350

transcription

IEA

GO:0007219

Notch signaling pathway

IDA

11101851

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

IDA

11101851

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005634

nucleus

IDA

11101851

GO:0016607

nuclear speck

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CDK8	K35 \| MGC126074 \| MGC126075	cyclin-dependent kinase 8	CDK8 interacts with MAM.	BIND	15546612
CREBBP	CBP \| KAT3A \| RSTS	CREB binding protein	-	HPRD,BioGRID	12050117
EP300	KAT3B \| p300	E1A binding protein p300	-	HPRD,BioGRID	12050117 \|12391150
EP300	KAT3B \| p300	E1A binding protein p300	p300 interacts with MAML1. This interaction was modeled on a demonstrated interaction between p300 from an unspecified species and human MAML1.	BIND	12391150
MAML2	DKFZp686N0150 \| KIAA1819 \| MAM-3 \| MAM2 \| MAM3 \| MGC176701 \| MLL-MAML2	mastermind-like 2 (Drosophila)	Affinity Capture-Western	BioGRID	12370315
MAML3	CAGH3 \| ERDA3 \| GDN \| MAM-2 \| MAM2 \| TNRC3	mastermind-like 3 (Drosophila)	Affinity Capture-Western	BioGRID	12370315
NOTCH1	TAN1 \| hN1	Notch homolog 1, translocation-associated (Drosophila)	-	HPRD,BioGRID	11101851
NOTCH2	AGS2 \| hN2	Notch homolog 2 (Drosophila)	-	HPRD,BioGRID	11101851
NOTCH3	CADASIL \| CASIL	Notch homolog 3 (Drosophila)	-	HPRD,BioGRID	11101851
NOTCH4	FLJ16302 \| INT3 \| MGC74442 \| NOTCH3	Notch homolog 4 (Drosophila)	Reconstituted Complex	BioGRID	11101851

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124/506	1532	1538	m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	1532	1538	m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-130/301	1122	1128	m8	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-133	79	85	1A	hsa-miR-133a	UUGGUCCCCUUCAACCAGCUGU
miR-133	79	85	1A	hsa-miR-133b	UUGGUCCCCUUCAACCAGCUA
miR-137	1926	1932	1A	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-142-5p	2201	2207	1A	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-23	1934	1940	m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	1934	1940	m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-24	1442	1448	1A	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-30-5p	2114	2121	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-323	1934	1940	1A	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-330	2097	2103	m8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-93.hd/291-3p/294/295/302/372/373/520	1255	1261	m8	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.