Gene Page: CDC2L1

Summary
GeneID  984
Symbol  CDC2L1
Synonyms  CDC2L2|CDK11|CDK11-p110|CDK11-p46|CDK11-p58|CLK-1|FLJ59152|PK58|p58|p58CDC2L1|p58CLK-1
Description  cell division cycle 2-like 1 (PITSLRE proteins)
See related  HGNC:1729|MIM:176873|Ensembl:ENSG00000008128|HPRD:08909|
Locus tag  RP1-283E3.2
Gene type  protein-coding
Map location  1p36.33
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.01 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RABL30.820.79
DLD0.810.79
TAX1BP10.810.80
OSGIN20.800.84
C6orf2110.800.78
MRPL190.790.78
USO10.790.74
PIGK0.790.80
GFM10.780.76
RAP1A0.780.76
Top 10 negatively co-expressed genes
AL022328.1-0.58-0.55
C16orf79-0.50-0.52
NUDT8-0.48-0.51
HES4-0.48-0.53
AC135724.1-0.47-0.44
C1orf61-0.46-0.43
IRF7-0.46-0.56
TMEM88-0.46-0.49
IL32-0.43-0.27
GZMM-0.42-0.39
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004693cyclin-dependent protein kinase activityIEAneuron (GO term level: 8)-
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIPI12624090 |17353931 
GO:0005524ATP bindingIDA12501247 
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001558regulation of cell growthIEP10882096 
GO:0006355regulation of transcription, DNA-dependentNAS9750192 
GO:0006468protein amino acid phosphorylationIDA12501247 
GO:0007049cell cycleIEA-
GO:0007067mitosisNAS1639388 
GO:0008283cell proliferationTAS8195233 
GO:0006915apoptosisNAS9750192 
GO:0050684regulation of mRNA processingIDA12501247 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA8195233 
GO:0005737cytoplasmTAS8195233 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CCND3-cyclin D3-HPRD,BioGRID12082095 
CCNL2ANIA-6B | CCNM | DKFZp761A1210 | DKFZp762O195 | HCLA-ISO | HLA-ISO | PCEE | SB138cyclin L2-HPRD14623875 |14684736 
RNPS1E5.1 | MGC117332RNA binding protein S1, serine-rich domainAffinity Capture-MSBioGRID17353931 
YWHABGW128 | HS1 | KCIP-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptideCDK11-p110 interacts with 14-3-3-beta.BIND15883043 
YWHAE14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDStyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptideCDK11-p110 interacts with 14-3-3-epsilon.BIND15883043 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptideCDK11-p110 interacts with 14-3-3-gamma.BIND15883043 
YWHAQ14-3-3 | 1C5 | HS1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptideCDK11-p110 interacts with 14-3-3-theta.BIND15883043 
 


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