Gene Page: CDC25A

Summary ?
GeneID993
SymbolCDC25A
SynonymsCDC25A2
Descriptioncell division cycle 25A
ReferenceMIM:116947|HGNC:HGNC:1725|Ensembl:ENSG00000164045|HPRD:00305|Vega:OTTHUMG00000133535
Gene typeprotein-coding
Map location3p21
Pascal p-value0.01
eGeneCerebellar Hemisphere
Cerebellum
SupportAscano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TUSC30.940.94
PWP10.930.94
SLC25A170.920.94
PPP3CC0.910.94
YWHAQ0.910.94
TTC130.910.92
ARMCX10.910.95
CCT50.910.93
STMN20.910.95
MRPL30.910.93
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.33-0.79-0.88
MT-CO2-0.78-0.86
AF347015.27-0.77-0.85
MT-CYB-0.76-0.86
AF347015.8-0.76-0.87
HLA-F-0.76-0.80
AF347015.31-0.76-0.84
AF347015.15-0.74-0.85
AF347015.2-0.74-0.87
AF347015.26-0.73-0.87

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARD1AARD1 | DXS707 | MGC71248 | TE2ARD1 homolog A, N-acetyltransferase (S. cerevisiae)Two-hybridBioGRID16189514 
BTRCBETA-TRCP | FBW1A | FBXW1 | FBXW1A | FWD1 | MGC4643 | bTrCP | bTrCP1 | betaTrCPbeta-transducin repeat containing-HPRD14603323 
CCNA1-cyclin A1-HPRD,BioGRID10926775 
CCNB1CCNBcyclin B1-HPRD,BioGRID1836978 
CCNE1CCNEcyclin E1-HPRD,BioGRID8617791 
CDK2p33(CDK2)cyclin-dependent kinase 2-HPRD,BioGRID8617791 
CDKN3CDI1 | CIP2 | FLJ25787 | KAP | KAP1 | MGC70625cyclin-dependent kinase inhibitor 3-HPRD,BioGRID9989807 
CHEK1CHK1CHK1 checkpoint homolog (S. pombe)Chk1 phosphorylates Cdc25A-b. This interaction was modeled on a demonstrated interaction between human Chk1 and Cdc25A from an unspecified species.BIND15311285 
CHEK1CHK1CHK1 checkpoint homolog (S. pombe)Chk1 phosphorylates Cdc25A-a. This interaction was modeled on a demonstrated interaction between human Chk1 and Cdc25A from an unspecified species.BIND15311285 
CHEK1CHK1CHK1 checkpoint homolog (S. pombe)-HPRD,BioGRID12399544 
CUX1CASP | CDP | CDP/Cut | CDP1 | COY1 | CUTL1 | CUX | Clox | Cux/CDP | GOLIM6 | Nbla10317 | p100 | p110 | p200 | p75cut-like homeobox 1-HPRD11584018 
E2F1E2F-1 | RBAP1 | RBBP3 | RBP3E2F transcription factor 1E2F1 interacts with the Cdc25A promoter region.BIND10766737 
E2F2E2F-2E2F transcription factor 2E2F2 interacts with the Cdc25A promoter region.BIND10766737 
E2F3DKFZp686C18211 | E2F-3 | KIAA0075 | MGC104598E2F transcription factor 3E2F3 interacts with the Cdc25A promoter.BIND10766737 
E2F4E2F-4E2F transcription factor 4, p107/p130-bindingE2F4 interacts with the Cdc25A promoter region.BIND10766737 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD,BioGRID11912208 
FBXW11BTRC2 | BTRCP2 | FBW1B | FBXW1B | Fbw11 | Hos | KIAA0696F-box and WD repeat domain containing 11-HPRD14603323 
HRASC-BAS/HAS | C-H-RAS | C-HA-RAS1 | CTLO | H-RASIDX | HAMSV | HRAS1 | K-RAS | N-RAS | RASH1v-Ha-ras Harvey rat sarcoma viral oncogene homolog-HPRD7744247 
MAP3K5ASK1 | MAPKKK5 | MEKK5mitogen-activated protein kinase kinase kinase 5-HPRD,BioGRID11416155 
MAPK14CSBP1 | CSBP2 | CSPB1 | EXIP | Mxi2 | PRKM14 | PRKM15 | RK | SAPK2A | p38 | p38ALPHAmitogen-activated protein kinase 14Reconstituted ComplexBioGRID12963847 
PIM1PIMpim-1 oncogene-HPRD,BioGRID10373478 
RAF1CRAF | NS5 | Raf-1 | c-Rafv-raf-1 murine leukemia viral oncogene homolog 1-HPRD,BioGRID9230211 |10373531 
ROCK1MGC131603 | MGC43611 | P160ROCK | PRO0435Rho-associated, coiled-coil containing protein kinase 1-HPRD,BioGRID14657354 
YWHABGW128 | HS1 | KCIP-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide-HPRD,BioGRID7644510 
YWHABGW128 | HS1 | KCIP-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide14-3-3-beta interacts with cdc25A.BIND7644510 
YWHAE14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDStyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide-HPRD,BioGRID7644510 
YWHAE14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDStyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide-HPRD7644510 |14559997 
YWHAE14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDStyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide14-3-3-epsilon interacts with cdc25A.BIND7644510 
YWHAZKCIP-1 | MGC111427 | MGC126532 | MGC138156tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide-HPRD,BioGRID11912208 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CELL CYCLE 12884All SZGR 2.0 genes in this pathway
KEGG PROGESTERONE MEDIATED OOCYTE MATURATION 8659All SZGR 2.0 genes in this pathway
BIOCARTA SRCRPTP PATHWAY 119All SZGR 2.0 genes in this pathway
BIOCARTA G1 PATHWAY 2821All SZGR 2.0 genes in this pathway
BIOCARTA G2 PATHWAY 2420All SZGR 2.0 genes in this pathway
BIOCARTA CELLCYCLE PATHWAY 2315All SZGR 2.0 genes in this pathway
BIOCARTA PTC1 PATHWAY 116All SZGR 2.0 genes in this pathway
SA G2 AND M PHASES 87All SZGR 2.0 genes in this pathway
PID E2F PATHWAY 7448All SZGR 2.0 genes in this pathway
PID ATR PATHWAY 3925All SZGR 2.0 genes in this pathway
PID MYC ACTIV PATHWAY 7962All SZGR 2.0 genes in this pathway
PID ATM PATHWAY 3425All SZGR 2.0 genes in this pathway
REACTOME G0 AND EARLY G1 2513All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421253All SZGR 2.0 genes in this pathway
REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT 5131All SZGR 2.0 genes in this pathway
REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION 105All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325185All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE CHECKPOINTS 12470All SZGR 2.0 genes in this pathway
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION 6540All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION 11263All SZGR 2.0 genes in this pathway
REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION 158All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES 13779All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G2 G2 M PHASES 8150All SZGR 2.0 genes in this pathway
REACTOME E2F MEDIATED REGULATION OF DNA REPLICATION 3517All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS 3818All SZGR 2.0 genes in this pathway
REACTOME G1 S SPECIFIC TRANSCRIPTION 199All SZGR 2.0 genes in this pathway
REACTOME G2 M CHECKPOINTS 4523All SZGR 2.0 genes in this pathway
REACTOME S PHASE 10966All SZGR 2.0 genes in this pathway
SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP 15184All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP 408247All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431263All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN DN 241146All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362238All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN 536332All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557331All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING DN 8749All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP 12895All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR DN 7550All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378231All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329196All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
CAIRO PML TARGETS BOUND BY MYC UP 2317All SZGR 2.0 genes in this pathway
TANG SENESCENCE TP53 TARGETS DN 5733All SZGR 2.0 genes in this pathway
STREICHER LSM1 TARGETS UP 4434All SZGR 2.0 genes in this pathway
NUNODA RESPONSE TO DASATINIB IMATINIB UP 2920All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800473All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747453All SZGR 2.0 genes in this pathway
WANG METHYLATED IN BREAST CANCER 3525All SZGR 2.0 genes in this pathway
OXFORD RALA OR RALB TARGETS UP 4823All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414287All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK 10173All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP 209139All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A DN 10371All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795478All SZGR 2.0 genes in this pathway
SCHWAB TARGETS OF BMYB POLYMORPHIC VARIANTS UP 139All SZGR 2.0 genes in this pathway
GARCIA TARGETS OF FLI1 AND DAX1 DN 176104All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379235All SZGR 2.0 genes in this pathway
BENPORATH ES 2 4021All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648385All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
REN BOUND BY E2F 6140All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE DN 245154All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337230All SZGR 2.0 genes in this pathway
VERNELL RETINOBLASTOMA PATHWAY UP 7047All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY HNE AND H2O2 3929All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371218All SZGR 2.0 genes in this pathway
SATO SILENCED EPIGENETICALLY IN PANCREATIC CANCER 4930All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS UP 7757All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C3 3624All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728415All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS RESPONSIVE TO ESTROGEN DN 4126All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY 4NQO OR UV 6344All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195135All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING UP 11580All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN 202132All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648398All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C 463262All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP 425253All SZGR 2.0 genes in this pathway
BONCI TARGETS OF MIR15A AND MIR16 1 9175All SZGR 2.0 genes in this pathway
WHITEFORD PEDIATRIC CANCER MARKERS 11663All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP 294199All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342220All SZGR 2.0 genes in this pathway
REICHERT G1S REGULATORS AS PI3K TARGETS 86All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
RUIZ TNC TARGETS DN 14279All SZGR 2.0 genes in this pathway
CHANG CYCLING GENES 14883All SZGR 2.0 genes in this pathway
LEE EARLY T LYMPHOCYTE UP 10759All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456285All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR DN 277166All SZGR 2.0 genes in this pathway
CROONQUIST IL6 DEPRIVATION DN 9869All SZGR 2.0 genes in this pathway
STEIN ESR1 TARGETS 8555All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR DN 251151All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2 277172All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605377All SZGR 2.0 genes in this pathway
DANG MYC TARGETS UP 143100All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE LITERATURE 4425All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G1 S 14776All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL 177132All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572352All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN 374217All SZGR 2.0 genes in this pathway
GABRIELY MIR21 TARGETS 289187All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
LINSLEY MIR16 TARGETS 206127All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882538All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 36HR 2923All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway
YU BAP1 TARGETS 2921All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 2HR UP 5333All SZGR 2.0 genes in this pathway