Gene Page: EXOG
Summary ?
| GeneID | 9941 |
| Symbol | EXOG |
| Synonyms | ENDOGL1|ENDOGL2|ENGL|ENGL-a|ENGL-b|ENGLA|ENGLB |
| Description | endo/exonuclease (5'-3'), endonuclease G-like |
| Reference | MIM:604051|HGNC:HGNC:3347|Ensembl:ENSG00000157036|HPRD:06813|Vega:OTTHUMG00000131295 |
| Gene type | protein-coding |
| Map location | 3p21.3 |
| Pascal p-value | 1.113E-4 |
| eGene | Anterior cingulate cortex BA24 Cerebellum Cortex |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs7373930 | 3 | 38454931 | EXOG | ENSG00000157036.8 | 1.95162E-6 | 0.04 | -82687 | gtex_brain_ba24 |
| rs9311188 | 3 | 38462379 | EXOG | ENSG00000157036.8 | 1.63781E-6 | 0.04 | -75239 | gtex_brain_ba24 |
| rs6599203 | 3 | 38487802 | EXOG | ENSG00000157036.8 | 2.59785E-6 | 0.04 | -49816 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| WNT4 | 0.52 | 0.41 |
| GRIN2D | 0.52 | 0.42 |
| TP53I3 | 0.51 | 0.29 |
| RGS19 | 0.50 | 0.37 |
| KLHL31 | 0.50 | 0.39 |
| WNT3 | 0.47 | 0.41 |
| PLA2G15 | 0.47 | 0.43 |
| GALNT14 | 0.47 | 0.37 |
| CHRNA4 | 0.47 | 0.41 |
| CNTN6 | 0.47 | 0.32 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AIF1L | -0.31 | -0.32 |
| AC021016.1 | -0.30 | -0.33 |
| RRAS | -0.28 | -0.31 |
| OAF | -0.28 | -0.32 |
| AF347015.2 | -0.28 | -0.30 |
| COPZ2 | -0.27 | -0.28 |
| NDUFA4L2 | -0.27 | -0.29 |
| AF347015.33 | -0.27 | -0.28 |
| AF347015.31 | -0.27 | -0.27 |
| COX4I2 | -0.27 | -0.32 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | - | |
| GO:0004519 | endonuclease activity | NAS | 10231028 | |
| GO:0016787 | hydrolase activity | IEA | - | |
| GO:0046872 | metal ion binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0008150 | biological_process | ND | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005575 | cellular_component | ND | - | |
| GO:0005739 | mitochondrion | IEA | - | |
| GO:0005743 | mitochondrial inner membrane | IEA | - | |
| GO:0016020 | membrane | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG APOPTOSIS | 88 | 62 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| PUJANA CHEK2 PCC NETWORK | 779 | 480 | All SZGR 2.0 genes in this pathway |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS DN | 637 | 377 | All SZGR 2.0 genes in this pathway |
| SHEPARD BMYB MORPHOLINO UP | 205 | 126 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS EARLY PROGENITOR | 532 | 309 | All SZGR 2.0 genes in this pathway |
| YAGI AML WITH 11Q23 REARRANGED | 351 | 238 | All SZGR 2.0 genes in this pathway |
| CHICAS RB1 TARGETS CONFLUENT | 567 | 365 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS UP | 504 | 321 | All SZGR 2.0 genes in this pathway |