SZGR2

Summary ?

GeneID	9968
Symbol	MED12
Synonyms	ARC240\|CAGH45\|FGS1\|HOPA\|MED12S\|OHDOX\|OKS\|OPA1\|TNRC11\|TRAP230
Description	mediator complex subunit 12
Reference	MIM:300188\|HGNC:HGNC:11957\|Ensembl:ENSG00000184634\|HPRD:02176\|Vega:OTTHUMG00000021788
Gene type	protein-coding
Map location	Xq13
Sherlock p-value	0.953
DEG p-value	DEG:Zhao_2015:p=3.07e-04:q=0.0924
Fetal beta	0.162
Support	Ascano FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DEG:Zhao_2015	RNA Sequencing analysis	Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder.
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association	A combined odds ratio method (Sun et al. 2008), association studies	2	Link to SZGene
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
ERAL1	0.88	0.85
MCRS1	0.87	0.84
TBRG4	0.87	0.85
C11orf49	0.86	0.83
SLC35B1	0.86	0.82
JAGN1	0.86	0.83
TMEM203	0.85	0.85
ZDHHC16	0.85	0.82
APEH	0.85	0.83
C7orf20	0.85	0.83

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.8	-0.68	-0.62
AF347015.18	-0.65	-0.68
MT-CO2	-0.65	-0.58
AF347015.26	-0.65	-0.62
AF347015.33	-0.63	-0.58
MT-CYB	-0.63	-0.59
AF347015.31	-0.63	-0.58
AF347015.27	-0.63	-0.60
MT-ATP8	-0.63	-0.66
AF347015.21	-0.63	-0.58

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004872	receptor activity	IDA		12218053
GO:0005515	protein binding	IPI		16109376
GO:0019904	protein domain specific binding	IPI		11984006
GO:0016455	RNA polymerase II transcription mediator activity	IDA		10198638
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	NAS		10235266
GO:0042809	vitamin D receptor binding	NAS		10235266
GO:0046966	thyroid hormone receptor binding	IDA		10198638
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006355	regulation of transcription, DNA-dependent	IEA		-
GO:0006367	transcription initiation from RNA polymerase II promoter	IDA		12218053
GO:0006350	transcription	IEA		-
GO:0030521	androgen receptor signaling pathway	IDA		12218053
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA		12037571
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000119	mediator complex	IDA		10198638
GO:0005813	centrosome	IDA		18029348
GO:0005634	nucleus	IDA		10235267
GO:0005730	nucleolus	IDA		18029348
GO:0005730	nucleolus	IDA		18029348

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CDK8	K35 \| MGC126074 \| MGC126075	cyclin-dependent kinase 8	Affinity Capture-MS	BioGRID	10198638
LYST	CHS \| CHS1	lysosomal trafficking regulator	-	HPRD,BioGRID	11984006
MED10	L6 \| MGC5309 \| NUT2 \| TRG20	mediator complex subunit 10	Affinity Capture-MS Affinity Capture-Western	BioGRID	15175163
MED19	DT2P1G7 \| LCMR1	mediator complex subunit 19	Affinity Capture-MS	BioGRID	15175163
MED26	CRSP7 \| CRSP70	mediator complex subunit 26	Affinity Capture-MS Affinity Capture-Western	BioGRID	15175163
MED28	1500003D12Rik \| DKFZp434N185 \| EG1 \| magicin	mediator complex subunit 28	Affinity Capture-MS	BioGRID	15175163
MED29	DKFZp434H247 \| IXL	mediator complex subunit 29	-	HPRD	14576168
MED29	DKFZp434H247 \| IXL	mediator complex subunit 29	Affinity Capture-MS	BioGRID	15175163
MED9	FLJ10193 \| MED25 \| MGC138234	mediator complex subunit 9	-	HPRD	14638676
MED9	FLJ10193 \| MED25 \| MGC138234	mediator complex subunit 9	Affinity Capture-MS	BioGRID	15175163
MYC	bHLHe39 \| c-Myc	v-myc myelocytomatosis viral oncogene homolog (avian)	Reconstituted Complex	BioGRID	12660246
PPARGC1A	LEM6 \| PGC-1(alpha) \| PGC-1v \| PGC1 \| PGC1A \| PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	Affinity Capture-Western Reconstituted Complex	BioGRID	14636573
SOX9	CMD1 \| CMPD1 \| SRA1	SRY (sex determining region Y)-box 9	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	12136106
THRA	AR7 \| EAR7 \| ERB-T-1 \| ERBA \| ERBA1 \| MGC000261 \| MGC43240 \| NR1A1 \| THRA1 \| THRA2 \| c-ERBA-1	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	Affinity Capture-MS Affinity Capture-Western	BioGRID	10198638
VDR	NR1I1	vitamin D (1,25- dihydroxyvitamin D3) receptor	Affinity Capture-MS	BioGRID	10198638 \|12837248

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
PID BETA CATENIN NUC PATHWAY	80	60	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME PPARA ACTIVATES GENE EXPRESSION	104	72	All SZGR 2.0 genes in this pathway
REACTOME GENERIC TRANSCRIPTION PATHWAY	352	181	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS	478	302	All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM	168	115	All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	72	53	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP	368	234	All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN UP	184	125	All SZGR 2.0 genes in this pathway
LAIHO COLORECTAL CANCER SERRATED DN	86	47	All SZGR 2.0 genes in this pathway
MAYBURD RESPONSE TO L663536 UP	29	18	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP	236	139	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
BENPORATH OCT4 TARGETS	290	172	All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS	734	436	All SZGR 2.0 genes in this pathway
BENPORATH NOS TARGETS	179	105	All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN	337	230	All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE DN	123	76	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN	270	181	All SZGR 2.0 genes in this pathway
AMBROSINI FLAVOPIRIDOL TREATMENT TP53	109	63	All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION	368	247	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-23	143	149	m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	143	149	m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-323	142	149	1A,m8	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-381	169	175	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-410	180	186	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-495	137	143	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: MED12