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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: MED12

Summary

GeneID

9968

Symbol

MED12

Synonyms

Description

mediator complex subunit 12

Locus tag

Gene type

protein-coding

Map location

Xq13

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

Association

A combined odds ratio method (Sun et al. 2008), association studies

Link to SZGene

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]

Click to show detail

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

ERAL1

0.88

0.85

MCRS1

0.87

0.84

TBRG4

0.87

0.85

C11orf49

0.86

0.83

SLC35B1

0.86

0.82

JAGN1

0.86

0.83

TMEM203

0.85

ZDHHC16

0.85

0.82

APEH

0.85

0.83

C7orf20

0.85

0.83

Top 10 negatively co-expressed genes

AF347015.8

-0.68

-0.62

AF347015.18

-0.65

-0.68

MT-CO2

-0.65

-0.58

AF347015.26

-0.65

-0.62

AF347015.33

-0.63

-0.58

MT-CYB

-0.63

-0.59

AF347015.31

-0.63

-0.58

AF347015.27

-0.63

-0.60

MT-ATP8

-0.63

-0.66

AF347015.21

-0.63

-0.58

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004872

receptor activity

IDA

12218053

GO:0005515

protein binding

IPI

16109376

GO:0019904

protein domain specific binding

IPI

11984006

GO:0016455

RNA polymerase II transcription mediator activity

IDA

10198638

GO:0030374

ligand-dependent nuclear receptor transcription coactivator activity

NAS

10235266

GO:0042809

vitamin D receptor binding

NAS

10235266

GO:0046966

thyroid hormone receptor binding

IDA

10198638

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006355

regulation of transcription, DNA-dependent

IEA

GO:0006367

transcription initiation from RNA polymerase II promoter

IDA

12218053

GO:0006350

transcription

IEA

GO:0030521

androgen receptor signaling pathway

IDA

12218053

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

IDA

12037571

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000119

mediator complex

IDA

10198638

GO:0005813

centrosome

IDA

18029348

GO:0005634

nucleus

IDA

10235267

GO:0005730

nucleolus

IDA

18029348

GO:0005730

nucleolus

IDA

18029348

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CDK8	K35 \| MGC126074 \| MGC126075	cyclin-dependent kinase 8	Affinity Capture-MS	BioGRID	10198638
LYST	CHS \| CHS1	lysosomal trafficking regulator	-	HPRD,BioGRID	11984006
MED10	L6 \| MGC5309 \| NUT2 \| TRG20	mediator complex subunit 10	Affinity Capture-MS Affinity Capture-Western	BioGRID	15175163
MED19	DT2P1G7 \| LCMR1	mediator complex subunit 19	Affinity Capture-MS	BioGRID	15175163
MED26	CRSP7 \| CRSP70	mediator complex subunit 26	Affinity Capture-MS Affinity Capture-Western	BioGRID	15175163
MED28	1500003D12Rik \| DKFZp434N185 \| EG1 \| magicin	mediator complex subunit 28	Affinity Capture-MS	BioGRID	15175163
MED29	DKFZp434H247 \| IXL	mediator complex subunit 29	-	HPRD	14576168
MED29	DKFZp434H247 \| IXL	mediator complex subunit 29	Affinity Capture-MS	BioGRID	15175163
MED9	FLJ10193 \| MED25 \| MGC138234	mediator complex subunit 9	-	HPRD	14638676
MED9	FLJ10193 \| MED25 \| MGC138234	mediator complex subunit 9	Affinity Capture-MS	BioGRID	15175163
MYC	bHLHe39 \| c-Myc	v-myc myelocytomatosis viral oncogene homolog (avian)	Reconstituted Complex	BioGRID	12660246
PPARGC1A	LEM6 \| PGC-1(alpha) \| PGC-1v \| PGC1 \| PGC1A \| PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	Affinity Capture-Western Reconstituted Complex	BioGRID	14636573
SOX9	CMD1 \| CMPD1 \| SRA1	SRY (sex determining region Y)-box 9	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	12136106
THRA	AR7 \| EAR7 \| ERB-T-1 \| ERBA \| ERBA1 \| MGC000261 \| MGC43240 \| NR1A1 \| THRA1 \| THRA2 \| c-ERBA-1	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	Affinity Capture-MS Affinity Capture-Western	BioGRID	10198638
VDR	NR1I1	vitamin D (1,25- dihydroxyvitamin D3) receptor	Affinity Capture-MS	BioGRID	10198638 \|12837248

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
PID_BETA_CATENIN_NUC_PATHWAY	80	60	All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY	396	292	All SZGR genes in this pathway
REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION	104	72	All SZGR genes in this pathway
REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	352	181	All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS	478	302	All SZGR genes in this pathway
REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM	168	115	All SZGR genes in this pathway
REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION	72	53	All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP	1382	904	All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP	368	234	All SZGR genes in this pathway
DOANE_RESPONSE_TO_ANDROGEN_UP	184	125	All SZGR genes in this pathway
LAIHO_COLORECTAL_CANCER_SERRATED_DN	86	47	All SZGR genes in this pathway
MAYBURD_RESPONSE_TO_L663536_UP	29	18	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN	1781	1082	All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_UP	236	139	All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS	988	594	All SZGR genes in this pathway
BENPORATH_OCT4_TARGETS	290	172	All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS	734	436	All SZGR genes in this pathway
BENPORATH_NOS_TARGETS	179	105	All SZGR genes in this pathway
PENG_GLUTAMINE_DEPRIVATION_DN	337	230	All SZGR genes in this pathway
KAYO_AGING_MUSCLE_DN	123	76	All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_DN	270	181	All SZGR genes in this pathway
AMBROSINI_FLAVOPIRIDOL_TREATMENT_TP53	109	63	All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION	368	247	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-23	143	149	m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	143	149	m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-323	142	149	1A,m8	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-381	169	175	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-410	180	186	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-495	137	143	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.