| 1 | Eur Neuropsychopharmacol 2005 Jan 15: 13-21 |
|---|---|
| PMID | 15572269 |
| Title | Amantadine for weight gain associated with olanzapine treatment. |
| Abstract | Patients with schizophrenia (Sch), schizoaffective, schizophreniform, or bipolar (BP) I disorders [Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV)]; not manic or acutely psychotic [Brief Psychiatric Rating Scale (BPRS) total score < or =45]; treated with olanzapine for 1-24 months; and who had gained > or =5% of their initial body weight were examined to determine whether amantadine could attenuate weight gain or promote weight loss. Olanzapine (Olz; 5-20 mg/day) was co-administered with double-blind treatment of 100-300 mg/day amantadine (Olz+AMT, n=60) or placebo (Olz+Plc, n=65). Visit-wise analysis of weight showed that weight change from baseline [last-observation-carried-forward (LOCF)] in the Olz+AMT group was significantly different from the Olz+Plc group at weeks 8 (P=0.042), 12 (P=0.029), and 16 (primary endpoint, mean+/-S.D.: -0.19+/-4.58 versus 1.28+/-4.26 kg, P=0.045). Mean BPRS total score, positive subscale, and anxiety-depression scores improved comparably in both groups, and Montgomery-Asberg Depression Rating Scale (MADRS) total score improved in the Olz+AMT group. Overall, amantadine was safe, was well tolerated, and attenuated weight gain or promoted weight loss in some patients who had gained weight during olanzapine therapy. |
| SCZ Keywords | schizophrenia, schizophrenic, schizophrenics |
| 2 | Cogn Neuropsychiatry 2007 Jul 12: 301-21 |
| PMID | 17558640 |
| Title | Overgeneral memory for public and autobiographical events in depression and schizophrenia. |
| Abstract | Memory for public and autobiographical events was investigated in people diagnosed with depression, schizophrenia, and a group of healthy controls. The aim was to determine whether the overgeneral memory effect emerged in clinical conditions other than depression and in memory domains other than autobiographical. 36 participants, 12 in each group, were administered four measures comprising the Hospital Anxiety and Depression Scale, the Autobiographical Memory Test (AMT), the Autobiographical Memory Interview (AMI), and a Public Events Memory Test; the latter developed by the authors and based on the AMT. A pattern of overgeneral autobiographical memory retrieval was found in both clinical groups. A similar pattern in retrieval of public events was also found in people diagnosed with depression and schizophrenia, indicating that overgeneral memory was characteristic of neither clinical condition nor was it associated with a particular memory domain. The findings suggest that overgeneral memory retrieval may represent a fundamental flaw in memory that arises when resources are limited. These findings are discussed in light of current theories of overgeneral memory retrieval. |
| SCZ Keywords | schizophrenia, schizophrenic, schizophrenics |