| 1 | Clin. Biochem. 2012 Jan 45: 49-53 |
|---|---|
| PMID | 22040815 |
| Title | Serum uric acid levels and the clinical characteristics of depression. |
| Abstract | This study was designed to investigate the correlation between serum uric acid (UA) levels and the clinical characteristics of depression. The serum UA levels were measured in 124 patients with depression, 660 patients with different types of other mental disorders (OMD) and 42 healthy subjects. Clinical characteristics of depression and OMD were also investigated. Depressive patients (271.97 ± 77.50 ?mol/L) had significantly lower UA levels than those with delirium, dementia, amnesia and other cognitive disorders (339.95 ± 141.74 ?mol/L, P=0.004), substances related disorders (359.61 ± 125.02 ?mol/L, P=0.022), schizophrenia (341.03 ± 106.84 ?mol/L, P=0.000), schizoaffective disorder (336.78 ± 155.49 ?mol/L, P=0.024), bipolar disorder (323.04 ± 108.70 ?mol/L, P=0.008) and the healthy control group (315.76 ± 87.50 ?mol/L, P=0.012). We also found that the UA levels of depressive patients normalised after a five week treatment with antidepressants. Our data suggested that a lowered UA level is another characteristic of depression. |
| SCZ Keywords | schizophrenia, schizophrenic |
| 2 | N Am J Med Sci 2014 Nov 6: 570-4 |
| PMID | 25535605 |
| Title | Psychosocial characteristics of oromucosal diseases in psychiatric patients: observational study from Indian dental college. |
| Abstract | Psychiatric diseases like anxiety, depression, schizophrenia and bipolar disorders can affect the mental and physical statuses of an individual. The study was to investigate the different oromucosal diseases (OMD) in psychiatric patients and to evaluate the correlation between these OMD to severity of anxiety and depression. A cross-sectional study was carried out during a six-month period. Patients reporting to psychiatry department with anxiety, depression, schizophrenia and bipolar disorder as diagnosed by an experienced psychiatrist, were subjected to complete oral examination by a skilled oral diagnostician to check for OMD like oral lichen planus (OLP), aphthous stomatitis (AS) and burning mouth syndrome (BMS). During the above mentioned time interval, 1320 patients with any of the above mentioned psychiatric diseases were included in this study. Of these, 278 had anxiety, 398 had depression, 295 had schizophrenia and 349 had bipolar disorder. Equal number of individuals reported to the Oral Medicine and Radiology department for routine oral screening with no mucosal diseases were included as control group. In this study, statistically significant increase in the OMD of the psychiatric patients was recorded when compared with the control group. The OMD were significantly higher in patients with anxiety (20.86%) followed by patients with depression (9.04%), schizophrenia (7.7%), bipolar disorder (7.4%) and control group (5.17%), respectively. Most prevalent OMD in patients with anxiety was AS (12%) followed by OLP (5.7%), and BMS (2.87%) respectively. Patients with moderate to severe anxiety and depression showed significantly higher prevalence of these OMD compared to the ones with mild anxiety and depression. The AS and OLP were significantly more in the younger age group (18-49 year) and BMS was higher in 50-77 year age group in both the study and control groups. A positive association was established between psychological alterations and OMD. Emotional alterations may act as a precipitating factor that could influence the initiation and development of different OMD. Hence, better harmonization is essential between dentist and psychiatrists for comprehensive management of psychosomatic disorders of the oral mucosa. |
| SCZ Keywords | schizophrenia, schizophrenic |