| 1 | J Psychiatr Res 2009 Oct 43: 1195-9 |
|---|---|
| PMID | 19435634 |
| Title | Three-cohort targeted gene screening reveals a non-synonymous TRKA polymorphism associated with schizophrenia. |
| Abstract | schizophrenia is a complex neurodevelopmental disorder that is thought to be induced by an interaction between predisposing genes and environmental stressors. To identify predisposing genetic factors, we performed a targeted (mostly neurodevelopmental) gene approach involving the screening of 396 selected non-synonymous single-nucleotide polymorphisms (SNPs) in three independent Caucasian schizophrenia case-control cohorts (USA, Denmark and Norway). A meta-analysis revealed ten non-synonymous SNPs that were nominally associated with schizophrenia, nine of which have not been previously linked to the disorder. Risk alleles are in TRKA (rs6336), BARD1 (rs28997576), LAMA5 (rs3810548), DKK2 (rs7037102), NOD2 (rs2066844) and RELN (rs2229860), whereas protective alleles are in NOD2 (rs2066845), NRG1 (rs10503929), ADAM7 (rs13259668) and TNR (rs859427). Following correction for multiple testing, the most attractive candidate for further study concerns SNP rs6336 (q=0.12) that causes the substitution of an evolutionarily highly conserved amino acid residue in the kinase domain of the neurodevelopmentally important receptor TRKA. Thus, TRKA signaling may represent a novel susceptibility pathway for schizophrenia. |
| SCZ Keywords | schizophrenia |
| 2 | Pol. Merkur. Lekarski 2010 Mar 28: 239-41 |
| PMID | 20815177 |
| Title | [Anxiety and depression in ulcerative colitis and Lesniovsky-Crohn's disease]. |
| Abstract | Ulcerative colitis and Lesniovsky-Crohn's disease are classified as idiopathic diseases. The study highlighted the role of the immune system, environmental and behavioral factors. Lists of infectious agents relevant to the development of ulcerative colitis and morbus Crohni, indicating the importance of the NOD2/CARD15 mutations. Quoted the results of studies on the effect of stress and immune response in patients with diagnosed ulcerative colitis. Discusses the implications arising from somatic mental patients, having regard to the causes of social isolation of patients and their rejection of social support. The study examined the results of research on quality of life of patients treated for ulcerative colitis and Crohn's disease. Stressed the importance of depression and anxiety in the development of idiopathic inflammatory bowel diseases. The results of studies showing the treatment of depression and anxiety as predictors of development idiopathic intestinal diseases were cited. The possibility of increased incidence of schizophrenia was excluded among people living with inflammatory nonspecific bowel disease. |
| SCZ Keywords | schizophrenia |