| 1 | Front Genet 2013 -1 4: 181 |
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| PMID | 24065983 |
| Title | Autoantibodies to neurotransmitter receptors and ion channels: from neuromuscular to neuropsychiatric disorders. |
| Abstract | Changes of voltage-gated ion channels and ligand-gated receptor channels caused by mutation or autoimmune attack are the cause of so-called channelopathies in the central and peripheral nervous system. We present the pathophysiology of channelopathies of the neuromuscular junction in terms of loss-of-function and gain-of-function principles. Autoantibodies generally have reduced access to the central nervous system, but in some cases this is enough to cause disease. A review is provided of recent findings implicating autoantibodies against ligand-activated receptor channels and potassium channels in psychiatric and neurological disorders, including schizophrenia and limbic encephalitis. The emergence of channelopathy-related neuropsychiatric disorders has implications for research and practice. |
| SCZ Keywords | schizophrenia |
| 2 | Biol. Psychiatry 2014 Feb 75: 284-91 |
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| PMID | 23988024 |
| Title | Antibodies to the N-methyl-D-aspartate receptor and other synaptic proteins in psychosis. |
| Abstract | This review concentrates on the evidence for autoantibodies to cell surface synaptic proteins in psychosis and schizophrenia. We and others have recently found antibodies to the N-methyl-D-aspartate receptor in first-episode psychosis. We describe the evidence for pathogenicity and disease-relevance of these antibodies, which builds on the novel field in neuroimmunology of cell surface antibody-associated central nervous system disorders. Relevant autoantibodies in psychosis and schizophrenia are likely to be those directed to cell surface proteins, in which the likelihood of pathogenicity is greater. We discuss the evidence for this from the field of paraneoplastic neurologic syndromes and the discovery of novel cell surface antigen central nervous system autoimmune syndromes. |
| SCZ Keywords | schizophrenia |