Protein-protein interaction for SYP

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Nodes, degree=1 Nodes, degree=2


Protein-protein interaction data for gene SYP

Degree = 1
Interactor A Interactor B Experimental method Source Pubmed
SYPGRB2Affinity Capture-WesternBioGRID7534299 
SYPEPORReconstituted ComplexBioGRID7534299 
SYPAP1G1Two-hybridBioGRID12498786 
SYPSTX1AAffinity Capture-WesternBioGRID7553862 
SYPSIAH2-HPRD,BioGRID11786535 
SYPSIAH1-HPRD,BioGRID11786535 

Degree = 2
Interactor A Interactor B Experimental method Source Pubmed
GRB2ZAP70Affinity Capture-WesternBioGRID7629168 
GRB2ITGA2B-HPRD,BioGRID8631894 |11964172 
GRB2AXLAxl interacts with an unspecified isoform of Grb2.BIND12470648 
-HPRD,BioGRID9178760 
GRB2PRNP-HPRD11571277 
GRB2SIGLEC7-HPRD8188688 
GRB2PTPN6-HPRD,BioGRID11964172 
GRB2EPHA2-HPRD,BioGRID12400011 
GRB2CLYBLAffinity Capture-MSBioGRID12577067 
GRB2IL2RB-HPRD,BioGRID10602027 
GRB2SNTA1-HPRD,BioGRID11278583 |11551227 
GRB2SPRY2-HPRD,BioGRID10940627 |12402043 
GRB2TUB-HPRD10455176 
GRB2CD22-HPRD,BioGRID11551923 
GRB2HTT-HPRD,BioGRID9079622 
HDP interacts with Grb2.BIND9079622 
GRB2PDGFRAAffinity Capture-WesternBioGRID8943348 
GRB2PTPRAAn unspecified isoform of GRB2 interacts with PTPRA.BIND8670803 
-HPRD,BioGRID7518772 |8670803 
|11923305 
GRB2ITGB4-HPRD9171350 
GRB2CD2AP-HPRD10339567 
GRB2BCL2A1-HPRD9670936 
GRB2NCKIPSD-HPRD11157975 |11509578 
-HPRD,BioGRID11157975 
GRB2IQGAP1Affinity Capture-MSBioGRID12577067 
GRB2IRS1-HPRD7488107 
Affinity Capture-Western; Reconstituted ComplexBioGRID8491186 |8536716 
|12173038 
GRB2KITKit interacts with Grb2. This interaction was modeled on a demonstrated interaction between mouse proteins.BIND10022833 
Grb2 interacts with c-Kit upon stimulation with SLF. This interaction was modeled on a demonstrated interaction between mouse Grb2 and human c-Kit.BIND7523381 
-HPRD,BioGRID10377264 
GRB2AXLAxl interacts with an unspecified isoform of Grb2.BIND12470648 
-HPRD,BioGRID9178760 
GRB2RHOUWrch-1 interacts with Grb2. This interaction was modeled on a demonstrated interaction between human Wrch-1 and Grb2 from an unspecified species.BIND15556869 
GRB2PTK2Tyrosine-phosphorylated FAK interacts with Grb2.BIND7597091 
-HPRD7997267 
Affinity Capture-Western; Reconstituted ComplexBioGRID8649427 |10085298 
|10806474 |12005431 
|12558988 
Grb2 interacts with FAK. This interaction was modeled on a demonstrated interaction between human Grb2 and mouse FAK.BIND9148935 
GRB2CSF1R-HPRD,BioGRID8262059 |9178909 
|9380408 
GRB2SYN1-HPRD8022809 
-HPRD,BioGRID8022809|10899172 
GRB2DRD3D3 interacts with Grb2.BIND9843378 
-HPRD,BioGRID11384839 
GRB2PIK3R2-HPRD8662998 
GRB2LAT-HPRD9489702 |12359715 
Affinity Capture-Western; Reconstituted ComplexBioGRID9489702 |11368773 
|12186560 
GRB2VAV1-HPRD,BioGRID7809090 
Grb2 interacts with VavBIND9013873 
GRB2SOCS1Socs1 interacts with Grb2. This interaction was modeled on a demonstrated interaction between mouse Socs1 and human Grb2.BIND10022833 
-HPRD,BioGRID10022833 
GRB2GRB7-HPRD10377264 
GRB2PTK2B-HPRD,BioGRID10329689 |10354709 
GRB2BCAR1-HPRD8649368 |8700507 
Affinity Capture-Western; Reconstituted ComplexBioGRID10085298 |10822386 
GRB2MAPK14-HPRD8695800 
GRB2GHR-HPRD,BioGRID9632636 
GRB2KHDRBS1-HPRD7799925 |8576157 
|12112020 
Affinity Capture-Western; Reconstituted ComplexBioGRID9872323 |10467411 
|11960376 
Grb2 interacts with Sam68.BIND9872323 
GRB2DRD4D4.7 interacts with Grb2.BIND9843378 
D4.4 interacts with Grb2.BIND9843378 
-HPRD,BioGRID9843378 
D4.2 interacts with Grb2.BIND9843378 
GRB2VAV3-HPRD,BioGRID11094073 
GRB2TFAP2AAffinity Capture-MSBioGRID12577067 
GRB2ADRB1beta-1-AR interacts with Grb2.BIND9843378 
GRB2ADRB2-HPRD,BioGRID9830057 
GRB2EPPK1Affinity Capture-MSBioGRID12577067 
GRB2EPHB1-HPRD,BioGRID8798570 
GRB2MET-HPRD,BioGRID7511210 |8662889 
|9660480 
GRB2IL6STAffinity Capture-Western; Reconstituted ComplexBioGRID9013873 
GRB2MAP2-HPRD,BioGRID10781592 |11546790|11546790 
GRB2SHC1Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted ComplexBioGRID7514169 |7524086 
|7535773 |8112292 
|8195171 |8294403 
|8491186 |8647288 
|8662733 |9045692 
|9083103 |9927207 
|10080542 |10477741 
|10570290 |11302736 
|11505033 |11964172 
|12441060 |12577067 
Shc interacts with Grb2. This interaction was modelled on a demonstrated interaction between Shc from human and Grb2 from rat and an unspecified species.BIND8084588 
-HPRD7524086 |7535773 
|8491186 |11707405 
An unspecified isoform of Grb2 interacts with the p52 isoform of Shc.BIND9148935 
Grb2 interacts with Shc.BIND7515480 |8112292 
|8939605 |10891441 
GRB2RAPSN-HPRD9856458 
GRB2KRT17Affinity Capture-MSBioGRID12577067 
GRB2APP-HPRD12485888 
GRB2ERBB2-HPRD11173924 |11606575|11606575 
-HPRD,BioGRID11606575 
GRB2EGFRGRB2 interacts with an unspecified isoform of EGFR. This interaction was modeled on a demonstrated interaction between human GRB2, and rat EGFR.BIND15782189 
-HPRD1322798 |7527043 
EGFR interacts with GRB2.BIND8305738 
Affinity Capture-MS; Affinity Capture-Western; Reconstituted ComplexBioGRID1322798 |7510700 
|7527043 |8647858 
|9050991 |10026169 
|10085134 |11960376 
|12577067 |16729043 
GRB2NTRK1-HPRD,BioGRID10748052 |11733534 
GRB2SPRY1-HPRD12402043 
GRB2FLT3-HPRD,BioGRID10080542 
GRB2CD28-HPRD,BioGRID7737275 |8576157 
|9694876 
GRB2SOS1Grb2 interacts with Sos1. This interaction was modelled on a demonstrated interaction between rat Grb2 and Sos1.BIND8112292 
-HPRD8479541 |8493579 
Affinity Capture-MS; Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybridBioGRID7510700 |7514169 
|7629168 |7664271 
|8112292 |8188688 
|8479541 |8695800 
|8810325 |9009162 
|9344843 |9872323 
|10207103 |10319320 
|10477741 |10570290 
|10716926 |11960376 
|11964172 |11997436 
|12577067 
GRB2 interacts with SOS. This interaction was modeled on a demonstrated interaction between human GRB2 and mouse SOS.BIND7862111 
Sos1 interacts with Grb2. This interaction was modeled on a demonstrated interaction between Sos1 and Grb2 from Bos taurus.BIND9374537 
GRB2SIT1-HPRD11433379 
GRB2NEU3-HPRD,BioGRID12730204 
GRB2DAG1-HPRD,BioGRID7744812 
GRB2LAT-HPRD9489702 |12359715 
Affinity Capture-Western; Reconstituted ComplexBioGRID9489702 |11368773 
|12186560 
GRB2MAP4K1-HPRD,BioGRID9346925 |9788432 
|9891069 
HPK1, a Ste-20 homologous serine/threonine kinase interacts with Grb2, an adaptor protein.BIND9891069 
GRB2PTPN22-HPRD,BioGRID11882361 
GRB2KHDRBS1-HPRD7799925 |8576157 
|12112020 
Affinity Capture-Western; Reconstituted ComplexBioGRID9872323 |10467411 
|11960376 
Grb2 interacts with Sam68.BIND9872323 
GRB2ADA-HPRD9299436 
GRB2LCP2Affinity Capture-Western; Reconstituted ComplexBioGRID8695800 |8995445 
|10204582 |10224278 
|11314042 
GRB2CBLGrb2 interacts with Cbl.BIND15782196 
c-Cbl interacts with Grb2. This interaction was modeled on a demonstrated interaction between human c-Cbl and Grb2 from an unspecified species.BIND11053437 
Affinity Capture-Western; Reconstituted Complex; Two-hybridBioGRID8083187 |9108392 
|9174058 |9178909 
|9367879 |9461587 
|9872323 |10086340 
|10204582 |10570290 
|11964172 |11997436 
-HPRD9108392 |9178909 
|11133830 |11964172 
GRB2PTPRE-HPRD,BioGRID10490839 
GRB2SRC-HPRD,BioGRID11964172 
GRB2PTK2Tyrosine-phosphorylated FAK interacts with Grb2.BIND7597091 
-HPRD7997267 
Affinity Capture-Western; Reconstituted ComplexBioGRID8649427 |10085298 
|10806474 |12005431 
|12558988 
Grb2 interacts with FAK. This interaction was modeled on a demonstrated interaction between human Grb2 and mouse FAK.BIND9148935 
GRB2PXNReconstituted ComplexBioGRID10085298 
GRB2USP6NLGrb2 interacts with RN-tre.BIND12399475 
-HPRD,BioGRID12399475 
GRB2FLT4-HPRD,BioGRID7675451 |7970715 
|8662748 |9927207 
GRB2DRD4D4.7 interacts with Grb2.BIND9843378 
D4.4 interacts with Grb2.BIND9843378 
-HPRD,BioGRID9843378 
D4.2 interacts with Grb2.BIND9843378 
GRB2HTT-HPRD,BioGRID9079622 
HDP interacts with Grb2.BIND9079622 
GRB2SHKBP1-HPRD,BioGRID11152963 
GRB2ITGA6-HPRD7556090 
GRB2MAP4K1-HPRD,BioGRID9346925 |9788432 
|9891069 
HPK1, a Ste-20 homologous serine/threonine kinase interacts with Grb2, an adaptor protein.BIND9891069 
GRB2CCL5-HPRD9009162 
GRB2HRAS-HPRD11352655 
GRB2ADAM15-HPRD,BioGRID11741929 
GRB2RALGPS1-HPRD,BioGRID10747847 
GRB2PTPN1-HPRD10660596 |12388170 
Reconstituted ComplexBioGRID8940134 |10660596 
GRB2EGFRGRB2 interacts with an unspecified isoform of EGFR. This interaction was modeled on a demonstrated interaction between human GRB2, and rat EGFR.BIND15782189 
-HPRD1322798 |7527043 
EGFR interacts with GRB2.BIND8305738 
Affinity Capture-MS; Affinity Capture-Western; Reconstituted ComplexBioGRID1322798 |7510700 
|7527043 |8647858 
|9050991 |10026169 
|10085134 |11960376 
|12577067 |16729043 
GRB2BCRGrb2 interacts with Bcr-Abl.BIND9872323 
-HPRD,BioGRID8112292 |9178913 
Tyrosine phosphorylated Bcr-Abl interacts with Grb2.BIND8112292 
GRB2SHC1Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted ComplexBioGRID7514169 |7524086 
|7535773 |8112292 
|8195171 |8294403 
|8491186 |8647288 
|8662733 |9045692 
|9083103 |9927207 
|10080542 |10477741 
|10570290 |11302736 
|11505033 |11964172 
|12441060 |12577067 
Shc interacts with Grb2. This interaction was modelled on a demonstrated interaction between Shc from human and Grb2 from rat and an unspecified species.BIND8084588 
-HPRD7524086 |7535773 
|8491186 |11707405 
An unspecified isoform of Grb2 interacts with the p52 isoform of Shc.BIND9148935 
Grb2 interacts with Shc.BIND7515480 |8112292 
|8939605 |10891441 
GRB2DOCK1Co-fractionation; Reconstituted ComplexBioGRID8657152 |12615911 
GRB2PSMD10-HPRD9009162 
GRB2TEK-HPRD7478529 |10521483 
GRB2MUC1-HPRD,BioGRID7664271 
GRB2PLCG1-HPRD,BioGRID9281317 
GRB2EGFRGRB2 interacts with an unspecified isoform of EGFR. This interaction was modeled on a demonstrated interaction between human GRB2, and rat EGFR.BIND15782189 
-HPRD1322798 |7527043 
EGFR interacts with GRB2.BIND8305738 
Affinity Capture-MS; Affinity Capture-Western; Reconstituted ComplexBioGRID1322798 |7510700 
|7527043 |8647858 
|9050991 |10026169 
|10085134 |11960376 
|12577067 |16729043 
GRB2MST1R-HPRD,BioGRID8918464 
GRB2CD72-HPRD10820378 
GRB2USP8-HPRD,BioGRID10982817 |13129930 
GRB2PDGFRB-HPRD,BioGRID7935391 
GRB2SHC3An unspecified isoform of GRB2 interacts with SHC3 (ShcC).BIND15735675 
GRB2JAK2-HPRD,BioGRID7500025 
GRB2SYN1-HPRD8022809 
-HPRD,BioGRID8022809|10899172 
GRB2EPS15Far WesternBioGRID7797522 
GRB2ANXA2-HPRD,BioGRID7510700 
GRB2PAG1-HPRD,BioGRID10790433 
GRB2VAV2-HPRD,BioGRID11606575 
GRB2RACGAP1Affinity Capture-MSBioGRID12577067 
GRB2TRAT1Reconstituted ComplexBioGRID10790433 
GRB2ADAM12-HPRD11127814 
GRB2MAP3K1Affinity Capture-Western; Reconstituted ComplexBioGRID9733714 
GRB2SOS1Grb2 interacts with Sos1. This interaction was modelled on a demonstrated interaction between rat Grb2 and Sos1.BIND8112292 
-HPRD8479541 |8493579 
Affinity Capture-MS; Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybridBioGRID7510700 |7514169 
|7629168 |7664271 
|8112292 |8188688 
|8479541 |8695800 
|8810325 |9009162 
|9344843 |9872323 
|10207103 |10319320 
|10477741 |10570290 
|10716926 |11960376 
|11964172 |11997436 
|12577067 
GRB2 interacts with SOS. This interaction was modeled on a demonstrated interaction between human GRB2 and mouse SOS.BIND7862111 
Sos1 interacts with Grb2. This interaction was modeled on a demonstrated interaction between Sos1 and Grb2 from Bos taurus.BIND9374537 
GRB2SKAP1-HPRD,BioGRID12171928 
GRB2ADAM10Affinity Capture-WesternBioGRID11741929 
GRB2SH2B2Affinity Capture-WesternBioGRID9856458 
GRB2CSF3R-HPRD,BioGRID9824671 
GRB2FRS2Affinity Capture-Western; Reconstituted ComplexBioGRID8780727 |9182757 
|10092678 |11997436 
-HPRD8780727|9182757|11997436 |12402043 
GRB2SOS1Grb2 interacts with Sos1. This interaction was modelled on a demonstrated interaction between rat Grb2 and Sos1.BIND8112292 
-HPRD8479541 |8493579 
Affinity Capture-MS; Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybridBioGRID7510700 |7514169 
|7629168 |7664271 
|8112292 |8188688 
|8479541 |8695800 
|8810325 |9009162 
|9344843 |9872323 
|10207103 |10319320 
|10477741 |10570290 
|10716926 |11960376 
|11964172 |11997436 
|12577067 
GRB2 interacts with SOS. This interaction was modeled on a demonstrated interaction between human GRB2 and mouse SOS.BIND7862111 
Sos1 interacts with Grb2. This interaction was modeled on a demonstrated interaction between Sos1 and Grb2 from Bos taurus.BIND9374537 
GRB2IRS4-HPRD,BioGRID9553137 
GRB2SHB-HPRD,BioGRID9484780 |10488157 
GRB2IRS1-HPRD7488107 
Affinity Capture-Western; Reconstituted ComplexBioGRID8491186 |8536716 
|12173038 
GRB2DNM1Affinity Capture-Western; Far Western; Reconstituted ComplexBioGRID8119878 |9009162 
-HPRD8119878 |11877424 
GRB2TFAP2BAffinity Capture-MSBioGRID12577067 
GRB2SOS2-HPRD,BioGRID7629138 |10940929 
GRB2MED28-HPRD,BioGRID15467741 
GRB2PIK3C2B-HPRD,BioGRID11533253 
GRB2BAT2-HPRD,BioGRID14667819 
GRB2PTPRAAn unspecified isoform of GRB2 interacts with PTPRA.BIND8670803 
-HPRD,BioGRID7518772 |8670803 
|11923305 
GRB2FRS2Affinity Capture-Western; Reconstituted ComplexBioGRID8780727 |9182757 
|10092678 |11997436 
-HPRD8780727|9182757|11997436 |12402043 
GRB2WASF1-HPRD9307968 
GRB2PLEC1Affinity Capture-MSBioGRID12577067 
GRB2BCRGrb2 interacts with Bcr-Abl.BIND9872323 
-HPRD,BioGRID8112292 |9178913 
Tyrosine phosphorylated Bcr-Abl interacts with Grb2.BIND8112292 
GRB2KRT18Affinity Capture-MSBioGRID12577067 
GRB2RASA1-HPRD,BioGRID12441060 
GRB2NCKIPSD-HPRD11157975 |11509578 
-HPRD,BioGRID11157975 
GRB2LAX1-HPRD,BioGRID12359715 
GRB2TNK2-HPRD,BioGRID8647288 
GRB2SYNCRIPReconstituted ComplexBioGRID9341187 
GRB2ALOX5-HPRD,BioGRID7929073 |8585605 
GRB2CBLGrb2 interacts with Cbl.BIND15782196 
c-Cbl interacts with Grb2. This interaction was modeled on a demonstrated interaction between human c-Cbl and Grb2 from an unspecified species.BIND11053437 
Affinity Capture-Western; Reconstituted Complex; Two-hybridBioGRID8083187 |9108392 
|9174058 |9178909 
|9367879 |9461587 
|9872323 |10086340 
|10204582 |10570290 
|11964172 |11997436 
-HPRD9108392 |9178909 
|11133830 |11964172 
GRB2PTPRC-HPRD8570203 
GRB2CBLB-HPRD,BioGRID10086340 
GRB2SOCS1Socs1 interacts with Grb2. This interaction was modeled on a demonstrated interaction between mouse Socs1 and human Grb2.BIND10022833 
-HPRD,BioGRID10022833 
GRB2PRKAR1A-HPRD,BioGRID9050991 
GRB2ERBB3Affinity Capture-MSBioGRID16729043 
GRB2VAV1-HPRD,BioGRID7809090 
Grb2 interacts with VavBIND9013873 
GRB2SOS1Grb2 interacts with Sos1. This interaction was modelled on a demonstrated interaction between rat Grb2 and Sos1.BIND8112292 
-HPRD8479541 |8493579 
Affinity Capture-MS; Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybridBioGRID7510700 |7514169 
|7629168 |7664271 
|8112292 |8188688 
|8479541 |8695800 
|8810325 |9009162 
|9344843 |9872323 
|10207103 |10319320 
|10477741 |10570290 
|10716926 |11960376 
|11964172 |11997436 
|12577067 
GRB2 interacts with SOS. This interaction was modeled on a demonstrated interaction between human GRB2 and mouse SOS.BIND7862111 
Sos1 interacts with Grb2. This interaction was modeled on a demonstrated interaction between Sos1 and Grb2 from Bos taurus.BIND9374537 
GRB2JAK1-HPRD,BioGRID8536716 |11527382 
GRB2CRKAffinity Capture-Western; Far Western; Reconstituted ComplexBioGRID8662907 |8810325 
|10970810 
-HPRD8662907 |10970810 
GRB2TP63-HPRD8695800 
GRB2KHDRBS2-HPRD10077576 
GRB2PAK1PAK1 interacts with Grb2.BIND12522133 
GRB2KHDRBS1-HPRD7799925 |8576157 
|12112020 
Affinity Capture-Western; Reconstituted ComplexBioGRID9872323 |10467411 
|11960376 
Grb2 interacts with Sam68.BIND9872323 
GRB2SHC1Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted ComplexBioGRID7514169 |7524086 
|7535773 |8112292 
|8195171 |8294403 
|8491186 |8647288 
|8662733 |9045692 
|9083103 |9927207 
|10080542 |10477741 
|10570290 |11302736 
|11505033 |11964172 
|12441060 |12577067 
Shc interacts with Grb2. This interaction was modelled on a demonstrated interaction between Shc from human and Grb2 from rat and an unspecified species.BIND8084588 
-HPRD7524086 |7535773 
|8491186 |11707405 
An unspecified isoform of Grb2 interacts with the p52 isoform of Shc.BIND9148935 
Grb2 interacts with Shc.BIND7515480 |8112292 
|8939605 |10891441 
GRB2REPS2-HPRD,BioGRID9422736 
GRB2ERBB4Affinity Capture-MSBioGRID16729043 
GRB2CALD1-HPRD10559276 
GRB2CBLGrb2 interacts with Cbl.BIND15782196 
c-Cbl interacts with Grb2. This interaction was modeled on a demonstrated interaction between human c-Cbl and Grb2 from an unspecified species.BIND11053437 
Affinity Capture-Western; Reconstituted Complex; Two-hybridBioGRID8083187 |9108392 
|9174058 |9178909 
|9367879 |9461587 
|9872323 |10086340 
|10204582 |10570290 
|11964172 |11997436 
-HPRD9108392 |9178909 
|11133830 |11964172 
GRB2GAB2Affinity Capture-Western; Reconstituted ComplexBioGRID10391903 |11782427 
|15143164 
-HPRD10068651 |11882361 
GRB2MAPK9Reconstituted ComplexBioGRID7642542 |9019171 
GRB2SOS1Grb2 interacts with Sos1. This interaction was modelled on a demonstrated interaction between rat Grb2 and Sos1.BIND8112292 
-HPRD8479541 |8493579 
Affinity Capture-MS; Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybridBioGRID7510700 |7514169 
|7629168 |7664271 
|8112292 |8188688 
|8479541 |8695800 
|8810325 |9009162 
|9344843 |9872323 
|10207103 |10319320 
|10477741 |10570290 
|10716926 |11960376 
|11964172 |11997436 
|12577067 
GRB2 interacts with SOS. This interaction was modeled on a demonstrated interaction between human GRB2 and mouse SOS.BIND7862111 
Sos1 interacts with Grb2. This interaction was modeled on a demonstrated interaction between Sos1 and Grb2 from Bos taurus.BIND9374537 
GRB2SOCS7-HPRD9344857 
GRB2PTPN11Affinity Capture-Western; Far Western; Reconstituted ComplexBioGRID8041791 |8702859 
|8995399 |9362449 
|9632781 |9824671 
|10080542 |10212213 
|10747947 
-HPRD8041791 |8702859 
|12531430 
Grb2 interacts with Syp via Syp SH2 domains.BIND7523381 |8195176 
GRB2MERTK-HPRD9891051 
GRB2LAT2-HPRD,BioGRID12514734 
GRB2BCRGrb2 interacts with Bcr-Abl.BIND9872323 
-HPRD,BioGRID8112292 |9178913 
Tyrosine phosphorylated Bcr-Abl interacts with Grb2.BIND8112292 
GRB2DRD4D4.7 interacts with Grb2.BIND9843378 
D4.4 interacts with Grb2.BIND9843378 
-HPRD,BioGRID9843378 
D4.2 interacts with Grb2.BIND9843378 
GRB2DRD3D3 interacts with Grb2.BIND9843378 
-HPRD,BioGRID11384839 
GRB2PTPN11Affinity Capture-Western; Far Western; Reconstituted ComplexBioGRID8041791 |8702859 
|8995399 |9362449 
|9632781 |9824671 
|10080542 |10212213 
|10747947 
-HPRD8041791 |8702859 
|12531430 
Grb2 interacts with Syp via Syp SH2 domains.BIND7523381 |8195176 
GRB2CHRM4M4 interacts with Grb2.BIND9843378 
GRB2USP6NLGrb2 interacts with RN-tre.BIND12399475 
-HPRD,BioGRID12399475 
GRB2SELL-HPRD,BioGRID8986819 
GRB2BCAR1-HPRD8649368 |8700507 
Affinity Capture-Western; Reconstituted ComplexBioGRID10085298 |10822386 
GRB2INSRAffinity Capture-WesternBioGRID9083103 
GRB2SH2B1-HPRD,BioGRID9856458 
GRB2CRKAffinity Capture-Western; Far Western; Reconstituted ComplexBioGRID8662907 |8810325 
|10970810 
-HPRD8662907 |10970810 
GRB2EGF-HPRD10973965 
GRB2FGFR1-HPRD9480847 
GRB2PTPN12-HPRD,BioGRID9135065 
GRB2ETV6Affinity Capture-Western; Far WesternBioGRID15143164 
GRB2CRKL-HPRD,BioGRID10477741 
GRB2INPP5D-HPRD,BioGRID8723348 
GRB2ABL1-HPRD9516488 
Affinity Capture-WesternBioGRID9407116 
GRB2PIK3R1p85 interacts with Grb2.BIND8662998 
-HPRD,BioGRID7642542 |7737969 
|7759531 
GRB2TOM1L1-HPRD,BioGRID11711534 
GRB2DNM1Affinity Capture-Western; Far Western; Reconstituted ComplexBioGRID8119878 |9009162 
-HPRD8119878 |11877424 
GRB2PDE4DPDE4D4 interacts with Grb2. This interaction was modelled on a demonstrated interaction between human PDE4D4 and Grb2 from an unspecified species.BIND10571082 
GRB2DTX1-HPRD,BioGRID9590294 
GRB2ACTA1Affinity Capture-MSBioGRID12577067 
GRB2FASLG-HPRD,BioGRID11741599 |12023017 
CD95L interacts with Grb2.BIND12023017 
GRB2DRD4D4.7 interacts with Grb2.BIND9843378 
D4.4 interacts with Grb2.BIND9843378 
-HPRD,BioGRID9843378 
D4.2 interacts with Grb2.BIND9843378 
GRB2SHC1Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted ComplexBioGRID7514169 |7524086 
|7535773 |8112292 
|8195171 |8294403 
|8491186 |8647288 
|8662733 |9045692 
|9083103 |9927207 
|10080542 |10477741 
|10570290 |11302736 
|11505033 |11964172 
|12441060 |12577067 
Shc interacts with Grb2. This interaction was modelled on a demonstrated interaction between Shc from human and Grb2 from rat and an unspecified species.BIND8084588 
-HPRD7524086 |7535773 
|8491186 |11707405 
An unspecified isoform of Grb2 interacts with the p52 isoform of Shc.BIND9148935 
Grb2 interacts with Shc.BIND7515480 |8112292 
|8939605 |10891441 
GRB2PIK3R1p85 interacts with Grb2.BIND8662998 
-HPRD,BioGRID7642542 |7737969 
|7759531 
GRB2WASAffinity Capture-Western; Reconstituted ComplexBioGRID8805332 |9307968 
-HPRD9307968 |10224664 
GRB2IRS2-HPRD9852124 
GRB2LY6G6F-HPRD,BioGRID12852788 
GRB2SYNJ2-HPRD9388224 
GRB2FGFR3-HPRD,BioGRID9045692 
GRB2PDE6G-HPRD,BioGRID12624098 
GRB2PTK2Tyrosine-phosphorylated FAK interacts with Grb2.BIND7597091 
-HPRD7997267 
Affinity Capture-Western; Reconstituted ComplexBioGRID8649427 |10085298 
|10806474 |12005431 
|12558988 
Grb2 interacts with FAK. This interaction was modeled on a demonstrated interaction between human Grb2 and mouse FAK.BIND9148935 
GRB2MAPK12-HPRD9019171 
GRB2SGCA-HPRD7744812 
GRB2KITKit interacts with Grb2. This interaction was modeled on a demonstrated interaction between mouse proteins.BIND10022833 
Grb2 interacts with c-Kit upon stimulation with SLF. This interaction was modeled on a demonstrated interaction between mouse Grb2 and human c-Kit.BIND7523381 
-HPRD,BioGRID10377264 
GRB2EGFRGRB2 interacts with an unspecified isoform of EGFR. This interaction was modeled on a demonstrated interaction between human GRB2, and rat EGFR.BIND15782189 
-HPRD1322798 |7527043 
EGFR interacts with GRB2.BIND8305738 
Affinity Capture-MS; Affinity Capture-Western; Reconstituted ComplexBioGRID1322798 |7510700 
|7527043 |8647858 
|9050991 |10026169 
|10085134 |11960376 
|12577067 |16729043 
GRB2HCLS1Reconstituted ComplexBioGRID9670936 
GRB2SH3KBP1-HPRD9507006|11152963 
SETA interacts with Grb2. This interaction was modelled on a demonstrated interaction between rat SETA and human Grb2BIND11152963 
Reconstituted ComplexBioGRID10921882 |11152963 
GRB2OCRL-HPRD,BioGRID9038219 
GRB2ELK1-HPRD8798570 
GRB2ABL1-HPRD9516488 
Affinity Capture-WesternBioGRID9407116 
GRB2KITKit interacts with Grb2. This interaction was modeled on a demonstrated interaction between mouse proteins.BIND10022833 
Grb2 interacts with c-Kit upon stimulation with SLF. This interaction was modeled on a demonstrated interaction between mouse Grb2 and human c-Kit.BIND7523381 
-HPRD,BioGRID10377264 
GRB2DCTN1-HPRD,BioGRID8955163 
GRB2KRT8Affinity Capture-MSBioGRID12577067 
GRB2SH3KBP1-HPRD9507006|11152963 
SETA interacts with Grb2. This interaction was modelled on a demonstrated interaction between rat SETA and human Grb2BIND11152963 
Reconstituted ComplexBioGRID10921882 |11152963 
GRB2RAPGEF1-HPRD,BioGRID8621483 
GRB2SH3BP2-HPRD,BioGRID9846481 
GRB2SH2B3-HPRD,BioGRID8649391 
GRB2SHC1Affinity Capture-MS; Affinity Capture-Western; Co-fractionation; Reconstituted ComplexBioGRID7514169 |7524086 
|7535773 |8112292 
|8195171 |8294403 
|8491186 |8647288 
|8662733 |9045692 
|9083103 |9927207 
|10080542 |10477741 
|10570290 |11302736 
|11505033 |11964172 
|12441060 |12577067 
Shc interacts with Grb2. This interaction was modelled on a demonstrated interaction between Shc from human and Grb2 from rat and an unspecified species.BIND8084588 
-HPRD7524086 |7535773 
|8491186 |11707405 
An unspecified isoform of Grb2 interacts with the p52 isoform of Shc.BIND9148935 
Grb2 interacts with Shc.BIND7515480 |8112292 
|8939605 |10891441 
GRB2JUB-HPRD10330178 
GRB2SH3KBP1-HPRD9507006|11152963 
SETA interacts with Grb2. This interaction was modelled on a demonstrated interaction between rat SETA and human Grb2BIND11152963 
Reconstituted ComplexBioGRID10921882 |11152963 
GRB2BLNK-HPRD,BioGRID9697839 |9705962 
GRB2TNFRSF1A-HPRD,BioGRID10359574 
GRB2GAB3-HPRD,BioGRID11739737 
GRB2KDR-HPRD,BioGRID10319320 
GRB2FRS3-HPRD11432792 
GRB2KRT7Affinity Capture-MSBioGRID12577067 
GRB2MTA3-HPRD11483358 
GRB2CBLGrb2 interacts with Cbl.BIND15782196 
c-Cbl interacts with Grb2. This interaction was modeled on a demonstrated interaction between human c-Cbl and Grb2 from an unspecified species.BIND11053437 
Affinity Capture-Western; Reconstituted Complex; Two-hybridBioGRID8083187 |9108392 
|9174058 |9178909 
|9367879 |9461587 
|9872323 |10086340 
|10204582 |10570290 
|11964172 |11997436 
-HPRD9108392 |9178909 
|11133830 |11964172 
GRB2ERBB2-HPRD11173924 |11606575|11606575 
-HPRD,BioGRID11606575 
GRB2PTPN11Affinity Capture-Western; Far Western; Reconstituted ComplexBioGRID8041791 |8702859 
|8995399 |9362449 
|9632781 |9824671 
|10080542 |10212213 
|10747947 
-HPRD8041791 |8702859 
|12531430 
Grb2 interacts with Syp via Syp SH2 domains.BIND7523381 |8195176 
GRB2GRLF1Affinity Capture-WesternBioGRID12441060 
GRB2ITK-HPRD,BioGRID10636929 
GRB2HNRNPC-HPRD,BioGRID9516488 
GRB2RET-HPRD9393871 
Reconstituted ComplexBioGRID7665556 |8183561 
GRB2PTK2Tyrosine-phosphorylated FAK interacts with Grb2.BIND7597091 
-HPRD7997267 
Affinity Capture-Western; Reconstituted ComplexBioGRID8649427 |10085298 
|10806474 |12005431 
|12558988 
Grb2 interacts with FAK. This interaction was modeled on a demonstrated interaction between human Grb2 and mouse FAK.BIND9148935 
GRB2GAB1-HPRD,BioGRID11314042 |11960376 
GRB2CDKN1B-HPRD,BioGRID11278754 
GRB2CTTN-HPRD11439336 
GRB2ARHGAP17Reconstituted ComplexBioGRID11431473 
GRB2GAB2Affinity Capture-Western; Reconstituted ComplexBioGRID10391903 |11782427 
|15143164 
-HPRD10068651 |11882361 
GRB2RET-HPRD9393871 
Reconstituted ComplexBioGRID7665556 |8183561 
GRB2WASF2-HPRD9307968 
GRB2MICAL1Reconstituted ComplexBioGRID11827972 
GRB2PTPN1-HPRD10660596 |12388170 
Reconstituted ComplexBioGRID8940134 |10660596 
GRB2FASLG-HPRD,BioGRID11741599 |12023017 
CD95L interacts with Grb2.BIND12023017 
GRB2MTA1-HPRD11483358 
GRB2SYK-HPRD,BioGRID11964172 
GRB2WASAffinity Capture-Western; Reconstituted ComplexBioGRID8805332 |9307968 
-HPRD9307968 |10224664 
GRB2WASL-HPRD,BioGRID10087612 |10781580 
EPORSOCS3-HPRD,BioGRID10882725 |12027890 
EPORGRAP-HPRD,BioGRID8647802 
EPOREPO-HPRD,BioGRID9808045 |10318834 
Interaction between EPOR (PDB ID: 1EER_C) and EPO (PDB ID: 1EER_A).BIND9774108 
Interaction between EPOR (PDB ID: 1EER_B) and EPO (PDB ID: 1EER_A).BIND9774108 
EPORKIT-HPRD11124255 
EPORMAPK3-HPRD12538595 
EPOREPO-HPRD,BioGRID9808045 |10318834 
Interaction between EPOR (PDB ID: 1EER_C) and EPO (PDB ID: 1EER_A).BIND9774108 
Interaction between EPOR (PDB ID: 1EER_B) and EPO (PDB ID: 1EER_A).BIND9774108 
EPORPTPN11-HPRD,BioGRID8639815 
EPOREPO-HPRD,BioGRID9808045 |10318834 
Interaction between EPOR (PDB ID: 1EER_C) and EPO (PDB ID: 1EER_A).BIND9774108 
Interaction between EPOR (PDB ID: 1EER_B) and EPO (PDB ID: 1EER_A).BIND9774108 
EPORCISH-HPRD9774439 
-HPRD,BioGRID7796808 
EPORMAPK1-HPRD12538595 
EPORKITLG-HPRD11124255 
EPORIRS2-HPRD,BioGRID9334184 
EPORSTAT5A-HPRD,BioGRID8977232 
EPORPIK3R1-HPRD,BioGRID7559499 
EPORCISH-HPRD9774439 
-HPRD,BioGRID7796808 
EPORCSF2RB-HPRD12488507 
EPORVAV1-HPRD,BioGRID9162069 
EPORGNB2L1EPOR interacts with RACK-1. This interaction was modelled on a demonstrated interaction between EPOR from an unspecified species and human RACK-1.BIND12960323 
-HPRD,BioGRID12960323 
EPORPTPN6-HPRD,BioGRID7889566 
EPORCRKL-HPRD,BioGRID11443118 
EPORGNB2L1EPOR interacts with RACK-1. This interaction was modelled on a demonstrated interaction between EPOR from an unspecified species and human RACK-1.BIND12960323 
-HPRD,BioGRID12960323 
EPORSOCS2-HPRD,BioGRID11781573 
EPORSHC1-HPRD,BioGRID8400282 
EPORJAK2-HPRD,BioGRID8343951 |11779507 
EPORLYN-HPRD,BioGRID9573010 
EPORGAB2-HPRD10455108 
EPORKLK3-HPRD10374881 
EPORSYK-HPRD,BioGRID9852052 
EPORGNAI1Reconstituted ComplexBioGRID12538595 
EPORATXN2L-HPRD,BioGRID11784712 
AP1G1DNER-HPRD11950833 
AP1G1RAB5ATwo-hybridBioGRID14665628 
AP1G1CLTC-HPRD,BioGRID11451993 
AP1G1ARF1-HPRD,BioGRID11926829 
AP1G1MAP1A-HPRD10747088 |11418592 
AP1G1CLINT1-HPRD,BioGRID12429846 
AP1G1AFTPH-HPRD14665628 
AP1G1KIF13A-HPRD,BioGRID11106728 
AP1G1AP1B1-HPRD,BioGRID9733768 
AP1G1AP1S1The gamma-1 and sigma-1A subunits of the AP-1 complex interact. This interaction was modeled on a demonstrated interaction between mouse gamma-1 and human sigma-1A.BIND15469849 
-HPRD,BioGRID9733768 
AP1G1AP1S1The gamma-1 and sigma-1A subunits of the AP-1 complex interact. This interaction was modeled on a demonstrated interaction between mouse gamma-1 and human sigma-1A.BIND15469849 
-HPRD,BioGRID9733768 
AP1G1NECAP2Affinity Capture-WesternBioGRID14665628 
AP1G1AP1S2-HPRD,BioGRID9733768 
AP1G1SPTB-HPRD10477754 
AP1G1NECAP1Affinity Capture-WesternBioGRID14665628 
AP1G1AP1M2-HPRD,BioGRID10535737 
AP1G1AP1GBP1-HPRD,BioGRID9653655 |10814529 
|12042876 
AP1G1AP1M1Affinity Capture-WesternBioGRID10535737 
AP1G1C4orf16C4orf16 (2c18) interacts with AP1G1 (gamma-1-adaptin).BIND15775984 
AP1G1RABEP1Reconstituted Complex; Two-hybridBioGRID12042876 |12505986 
STX1ACACNA1D-HPRD10468580 
STX1ASTX8-HPRD11101518 
STX1ATRDMT1Two-hybridBioGRID16169070 
STX1ASYT4-HPRD10397765 
STX1ANAPAAffinity Capture-Western; Reconstituted ComplexBioGRID7553862 |7622514 
STX1ASNAP29-HPRD,BioGRID9852078 
STX1AVAMP2Affinity Capture-Western; Co-crystal Structure; Far Western; Reconstituted Complex; Two-hybridBioGRID7553862 |9030619 
|10100611 |10449403 
|11832227 |12093152 
STX1AVAMP8-HPRD,BioGRID11112705 
STX1ASYT7-HPRD7791877 
STX1ASNAP25-HPRD7622514 |7768895 
|9556632 |10373452 
|11509230|10954418 
-HPRD7622514 |9556632|10954418 
Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybridBioGRID7553862 |7768895 
|7961655 |8663154 
|9852078 |10195194 
|10449403 |10954418 
|11524423 |11832227 
|16169070 
STX1ATXLNAReconstituted ComplexBioGRID12558796 
STX1AUNC13B-HPRD,BioGRID8999968 
STX1AAPBA1-HPRD9395480 
STX1ASLC6A9-HPRD,BioGRID10722844 
STX1ASNAP25-HPRD7622514 |7768895 
|9556632 |10373452 
|11509230|10954418 
-HPRD7622514 |9556632|10954418 
Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybridBioGRID7553862 |7768895 
|7961655 |8663154 
|9852078 |10195194 
|10449403 |10954418 
|11524423 |11832227 
|16169070 
STX1ASTXBP1Affinity Capture-Western; Reconstituted ComplexBioGRID7553862 |7768895 
|10449403 |12093152 
|12963086 
-HPRD9045631 
STX1ASNAP25-HPRD7622514 |7768895 
|9556632 |10373452 
|11509230|10954418 
-HPRD7622514 |9556632|10954418 
Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybridBioGRID7553862 |7768895 
|7961655 |8663154 
|9852078 |10195194 
|10449403 |10954418 
|11524423 |11832227 
|16169070 
STX1ASCNN1G-HPRD,BioGRID14996668 
STX1ACPLX1Affinity Capture-Western; Co-crystal Structure; Reconstituted ComplexBioGRID10449403 |11832227 
|12200427 
-HPRD7553862 
STX1ARNF40Affinity Capture-Western; Reconstituted ComplexBioGRID12121982 
STX1ASEPT5-HPRD10321247 
STX1ASTXBP1Affinity Capture-Western; Reconstituted ComplexBioGRID7553862 |7768895 
|10449403 |12093152 
|12963086 
-HPRD9045631 
STX1AKCNB1-HPRD12403834 
STX1ASLC6A3DAT interacts with Syn1A.BIND15202772 
STX1ASNAP23-HPRD12209004|12651853 
Affinity Capture-Western; Reconstituted Complex; Two-hybridBioGRID8663154 |9168999 
|9852078 |12651853 
|12828989 
STX1APSEN1PS1 interacts with syntaxin 1A.BIND10891589 
STX1ACFTRSyntaxin 1A interacts with CFTR.BIND9384384 |12446681 
-HPRD,BioGRID9384384 
STX1ATXLNB-HPRD,BioGRID15184072 
STX1ASCNN1AAffinity Capture-WesternBioGRID14996668 
STX1ASYT1-HPRD,BioGRID9010211 
STX1ASCNN1BAffinity Capture-WesternBioGRID14996668 
-HPRD11845306 
STX1ASCNN1BAffinity Capture-WesternBioGRID14996668 
-HPRD11845306 
STX1ASLC6A4-HPRD,BioGRID12175857 
STX1AKIAA1128Two-hybridBioGRID16169070 
STX1ACDK5-HPRD,BioGRID9478941 
STX1ASLC6A1-HPRD,BioGRID9698305 |11017172 
|11960023 
STX1AVAPBReconstituted ComplexBioGRID12651853 
STX1ARAB27A-HPRD12101244 
STX1ASNAP23-HPRD12209004|12651853 
Affinity Capture-Western; Reconstituted Complex; Two-hybridBioGRID8663154 |9168999 
|9852078 |12651853 
|12828989 
STX1ASTXBP6-HPRD12145319 
STX1ACFTRSyntaxin 1A interacts with CFTR.BIND9384384 |12446681 
-HPRD,BioGRID9384384 
STX1ASTXBP2-HPRD,BioGRID7768895 |9045631 
STX1ACPLX2Affinity Capture-WesternBioGRID10449403 
STX1AVIMTwo-hybridBioGRID16169070 
STX1ACPLX1Affinity Capture-Western; Co-crystal Structure; Reconstituted ComplexBioGRID10449403 |11832227 
|12200427 
-HPRD7553862 
STX1AATP6V1B1Reconstituted ComplexBioGRID12651853 
STX1ASYTL4-HPRD,BioGRID12101244 
STX1ASLC6A5Affinity Capture-WesternBioGRID10722844 
STX1ANSF-HPRD7622514 
STX1AVAMP1Two-hybridBioGRID12093152 
STX1AVAMP7-HPRD,BioGRID12853575 
STX1AVPS18VPS18 interacts with STX1A (Syntaxin-1). This interaction was modeled on a demonstrated interaction between human VPS18 and STX1A (Syntaxin-1) from an unspecified species.BIND14623309 
STX1AVPS11VPS11 interacts with STX1A (Syntaxin-1). This interaction was modeled on a demonstrated interaction between human VPS11 and STX1A (Syntaxin-1) from an unspecified species.BIND14623309 
STX1ASEPT2-HPRD10321247 
STX1ASTXBP5-HPRD,BioGRID9620695 
SIAH2UBE2IhSiah2 interacts with Ubc9.BIND9334332 
Ubc9 interacts with Siah-2.BIND9334332 
SIAH2TRAF2-HPRD,BioGRID12411493 
SIAH2DCC-HPRD,BioGRID9858595 
DCC interacts with Siah-2.BIND9334332 
hSiah2 interacts with DCC.BIND9334332 
SIAH2DCC-HPRD,BioGRID9858595 
DCC interacts with Siah-2.BIND9334332 
hSiah2 interacts with DCC.BIND9334332 
SIAH2VAV1-HPRD,BioGRID10207103 
SIAH2UBE2IhSiah2 interacts with Ubc9.BIND9334332 
Ubc9 interacts with Siah-2.BIND9334332 
SIAH2POU2AF1-HPRD11483518 
SIAH2DCC-HPRD,BioGRID9858595 
DCC interacts with Siah-2.BIND9334332 
hSiah2 interacts with DCC.BIND9334332 
SIAH2UBE2L6-HPRD,BioGRID11786535 
SIAH2PEG3-HPRD,BioGRID10681424 
SIAH2PEG10-HPRD,BioGRID12810624 
SIAH2RBBP8Reconstituted ComplexBioGRID14654780 
SIAH1DAB1-HPRD,BioGRID12646221 
SIAH1UBE2D1-HPRD,BioGRID11389839 
SIAH1DCC-HPRD,BioGRID9858595 
DCC interacts with Siah-1.BIND9334332 
hSiah1 interacts with DCC cytoplasmic domain.BIND9334332 
SIAH1DCC-HPRD,BioGRID9858595 
DCC interacts with Siah-1.BIND9334332 
hSiah1 interacts with DCC cytoplasmic domain.BIND9334332 
SIAH1DCC-HPRD,BioGRID9858595 
DCC interacts with Siah-1.BIND9334332 
hSiah1 interacts with DCC cytoplasmic domain.BIND9334332 
SIAH1EIF3J-HPRD,BioGRID9822659 
SIAH1CACYBP-HPRD,BioGRID11389839 
SIAH1SKP1-HPRD11389839 
SIAH1UBE2IUbc9 interacts with Siah-1.BIND9334332 
hSiah1 interacts with Ubc9.BIND9334332 
SIAH1PEG3-HPRD,BioGRID10681424 
SIAH1UBE2E3Two-hybridBioGRID11389839 
SIAH1TUBA3C-HPRD11146551 
SIAH1VAV1Two-hybridBioGRID10207103 
SIAH1APC-HPRD,BioGRID11389840 
SIAH1PEG10-HPRD,BioGRID12810624 
SIAH1TUBA8-HPRD11146551 
SIAH1NUMB-HPRD,BioGRID11752454 
SIAH1KIF22-HPRD,BioGRID11146551 
SIAH1BAG1-HPRD,BioGRID9582267 
SIAH1TBL1X-HPRD,BioGRID11389839 
SIAH1TUBA1B-HPRD11146551 
SIAH1TUBA4A-HPRD11146551 
SIAH1UBE2IUbc9 interacts with Siah-1.BIND9334332 
hSiah1 interacts with Ubc9.BIND9334332 
SIAH1KHDRBS3-HPRD,BioGRID15163637 
SIAH1POU2AF1-HPRD,BioGRID11483517 |11483518 
SIAH1AFF4Two-hybridBioGRID16189514 
SIAH1TUBA1A-HPRD11146551 
SIAH1RBBP8Affinity Capture-Western; Reconstituted Complex; Two-hybridBioGRID14654780 


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