Gene Set: Gene Network


     Gene set description
  • Name: Gene Network
  • Method: Shortest path distance of core genes in the Human protein-protein interaction network
  • Number of genes: 1035
  • Reference: Wu et al. (2008). Network-based global inference of human disease genes. Mol Syst Biol 4 PubMed
  • Summary: We first mapped core genes on the human protein-protein interaction network, which we have collected from 6 PPI databases in advance. We then identified all shortest paths for any pair of core genes in this human interactome. Finally, we collected all genes whose coding proteins are located on these shortest paths and assigned scores to them based on their closeness to core genes.  Detailed information can be found here.
     Gene List

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Sort by   Gene ID   Symbol    Full Name   Location 

Gene ID Symbol Official Full Name Location
2773GNAI3guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 31p13
56944OLFML3olfactomedin-like 31p13.2
29899GPSM2G-protein signaling modulator 2 (AGS3-like, C. elegans)1p13.3
55791C1orf103chromosome 1 open reading frame 1031p13.3
1901S1PR1sphingosine-1-phosphate receptor 11p21
8458TTF2transcription termination factor, RNA polymerase II1p22
51100SH3GLB1SH3-domain GRB2-like endophilin B11p22
6125RPL5ribosomal protein L51p22.1
57489ODF2Louter dense fiber of sperm tails 2-like1p22.3
5142PDE4Bphosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)1p31
10207INADLInaD-like (Drosophila)1p31.3
2060EPS15epidermal growth factor receptor pathway substrate 151p32
10657KHDRBS1KH domain containing, RNA binding, signal transduction associated 11p32
1600DAB1disabled homolog 1 (Drosophila)1p32-p31
23499MACF1microtubule-actin crosslinking factor 11p32-p31
3716JAK1Janus kinase 1 (a protein tyrosine kinase)1p32.3-p31.3
2035EPB41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)1p33-p32
204AK2adenylate kinase 21p34
4904YBX1Y box binding protein 11p34
7804LRP8low density lipoprotein receptor-related protein 8, apolipoprotein e receptor1p34
553115PEF1penta-EF-hand domain containing 11p34
991CDC20cell division cycle 20 homolog (S. cerevisiae)1p34.1
1263PLK3polo-like kinase 3 (Drosophila)1p34.1
8503PIK3R3phosphoinositide-3-kinase, regulatory subunit 3 (gamma)1p34.1
84967LSM10LSM10, U7 small nuclear RNA associated1p34.3
5724PTAFRplatelet-activating factor receptor1p35-p34.3
10076PTPRUprotein tyrosine phosphatase, receptor type, U1p35.3-p35.1
1855DVL1dishevelled, dsh homolog 1 (Drosophila)1p36
998CDC42cell division cycle 42 (GTP binding protein, 25kDa)1p36.1
1650DDOSTdolichyl-diphosphooligosaccharide-protein glycosyltransferase1p36.1
4985OPRD1opioid receptor, delta 11p36.1-p34.3
2048EPHB2EPH receptor B21p36.1-p35
25932CLIC4chloride intracellular channel 41p36.11
23095KIF1Bkinesin family member 1B1p36.2
5394EXOSC10exosome component 101p36.22
56998CTNNBIP1catenin, beta interacting protein 11p36.22
4524MTHFR5,10-methylenetetrahydrofolate reductase (NADPH)1p36.3
5226PGDphosphogluconate dehydrogenase1p36.3-p36.13
1676DFFADNA fragmentation factor, 45kDa, alpha polypeptide1p36.3-p36.2
7133TNFRSF1Btumor necrosis factor receptor superfamily, member 1B1p36.3-p36.2
55052MRPL20mitochondrial ribosomal protein L201p36.3-p36.2
984CDC2L1cell division cycle 2-like 1 (PITSLRE proteins)1p36.33
2782GNB1guanine nucleotide binding protein (G protein), beta polypeptide 11p36.33
5590PRKCZprotein kinase C, zeta1p36.33-p36.2
26994RNF11ring finger protein 111pter-p22.1
6464SHC1SHC (Src homology 2 domain containing) transforming protein 11q21
9869SETDB1SET domain, bifurcated 11q21
56893UBQLN4ubiquilin 41q21
3765KCNJ9potassium inwardly-rectifying channel, subfamily J, member 91q21-q23
9507ADAMTS4ADAM metallopeptidase with thrombospondin type 1 motif, 41q21-q23
8407TAGLN2transgelin 21q21-q25
8682PEA15phosphoprotein enriched in astrocytes 151q21.1
4000LMNAlamin A/C1q21.2-q21.3
9898UBAP2Lubiquitin associated protein 2-like1q21.3
23557SNAPINSNAP-associated protein1q21.3
200186CRTC2CREB regulated transcription coactivator 21q21.3
4653MYOCmyocilin, trabecular meshwork inducible glucocorticoid response1q23-q24
8490RGS5regulator of G-protein signaling 51q23.1
5999RGS4regulator of G-protein signaling 41q23.3
27ABL2v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)1q24-q25
27101CACYBPcalcyclin binding protein1q24-q25
22920KIFAP3kinesin-associated protein 31q24.2
6004RGS16regulator of G-protein signaling 161q25-q31
2752GLULglutamate-ammonia ligase (glutamine synthetase)1q31
3915LAMC1laminin, gamma 1 (formerly LAMB2)1q31
5208PFKFB26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 21q31
5997RGS2regulator of G-protein signaling 2, 24kDa1q31
23612PHLDA3pleckstrin homology-like domain, family A, member 31q31
5788PTPRCprotein tyrosine phosphatase, receptor type, C1q31-q32
5664PSEN2presenilin 2 (Alzheimer disease 4)1q31-q42
64407RGS18regulator of G-protein signaling 181q31.2
4194MDM4Mdm4 p53 binding protein homolog (mouse)1q32
9261MAPKAPK2mitogen-activated protein kinase-activated protein kinase 21q32
134ADORA1adenosine A1 receptor1q32.1
493ATP2B4ATPase, Ca++ transporting, plasma membrane 41q32.1
9641IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon1q32.1
23114NFASCneurofascin homolog (chicken)1q32.1
59349KLHL12kelch-like 12 (Drosophila)1q32.1
5362PLXNA2plexin A21q32.2
7042TGFB2transforming growth factor, beta 21q41
25782RAB3GAP2RAB3 GTPase activating protein subunit 2 (non-catalytic)1q41
142PARP1poly (ADP-ribose) polymerase 11q41-q42
2058EPRSglutamyl-prolyl-tRNA synthetase1q41-q42
375ARF1ADP-ribosylation factor 11q42
9804TOMM20translocase of outer mitochondrial membrane 20 homolog (yeast)1q42
88ACTN2actinin, alpha 21q42-q43
3930LBRlamin B receptor1q42.1
7159TP53BP2tumor protein p53 binding protein, 21q42.1
27185DISC1disrupted in schizophrenia 11q42.1
6262RYR2ryanodine receptor 2 (cardiac)1q42.1-q43
3707ITPKBinositol 1,4,5-trisphosphate 3-kinase B1q42.13
84033OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF1q42.13
58ACTA1actin, alpha 1, skeletal muscle1q42.13|1q42.13-q42.2
149371EXOC8exocyst complex component 81q42.2
1131CHRM3cholinergic receptor, muscarinic 31q43
6000RGS7regulator of G-protein signaling 71q43|1q23.1
3688ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)10p11.2
8453CUL2cullin 210p11.21
1326MAP3K8mitogen-activated protein kinase kinase kinase 810p11.23
2572GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)10p11.23

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