Gene Page: KHDRBS1

Summary
GeneID  10657
Symbol  KHDRBS1
Synonyms  FLJ34027|Sam68|p62
Description  KH domain containing, RNA binding, signal transduction associated 1
See related  HGNC:18116|MIM:602489|Ensembl:ENSG00000121774|HPRD:03926|
Locus tag  -
Gene type  protein-coding
Map location  1p32
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0551 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ZBTB7A0.870.91
MYPOP0.870.85
CBX70.860.87
CEND10.850.86
RP5-1187M17.10.840.81
PANX20.840.83
ABLIM20.830.79
ZFYVE280.830.88
GABRD0.830.85
IQSEC30.810.80
Top 10 negatively co-expressed genes
TUBB2B-0.52-0.57
KIAA1949-0.51-0.47
FADS2-0.51-0.51
TRAF4-0.51-0.60
ZNF311-0.50-0.49
DYNLT1-0.50-0.68
CD24-0.50-0.41
SH3BP2-0.50-0.55
ZNF300-0.49-0.45
TIGD1-0.49-0.48
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingTAS1374686 
GO:0003723RNA bindingIDA1374686 
GO:0005070SH3/SH2 adaptor activityIPI9045636 
GO:0005515protein bindingIPI9045636 |11278465 |11585385 
|16341228 
GO:0017124SH3 domain bindingIEA-
GO:0016564transcription repressor activityISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000086G2/M transition of mitotic cell cycleISS-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006397mRNA processingTAS1374686 
GO:0007166cell surface receptor linked signal transductionIDA9045636 
GO:0007049cell cycleIEA-
GO:0007050cell cycle arrestTAS9013542 
GO:0008283cell proliferationTAS9013542 
GO:0016481negative regulation of transcriptionISS-
GO:0046831regulation of RNA export from nucleusISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA1374686 
GO:0016020membraneIDA1374686 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BTKAGMX1 | AT | ATK | BPK | IMD1 | MGC126261 | MGC126262 | PSCTK1 | XLABruton agammaglobulinemia tyrosine kinase-HPRD,BioGRID9201297 
CREBBPCBP | KAT3A | RSTSCREB binding protein-HPRD,BioGRID12496368 
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)Reconstituted ComplexBioGRID1545818 
DHX9DDX9 | LKP | NDHII | RHADEAH (Asp-Glu-Ala-His) box polypeptide 9-HPRD,BioGRID10951562 
EMG1C2F | FLJ60792 | Grcc2f | NEP1EMG1 nucleolar protein homolog (S. cerevisiae)Two-hybridBioGRID16169070 
FNBP4DKFZp686M14102 | DKFZp779I1064 | FBP30 | FLJ41904 | KIAA1014formin binding protein 4-HPRD,BioGRID10748127 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD,BioGRID9045636 
GRAP2GADS | GRAP-2 | GRB2L | GRBLG | GRID | GRPL | GrbX | Grf40 | Mona | P38GRB2-related adaptor protein 2GRAP2 (GRID) interacts with KHDRBS1 (Sam68).BIND10820259 
-HPRD,BioGRID9872323 |10820259 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD7799925 |8576157 
|12112020 
Affinity Capture-Western
Reconstituted Complex		BioGRID9872323 |10467411 
|11960376 
Grb2 interacts with Sam68.BIND9872323 
HCKJTK9hemopoietic cell kinaseHck interacts with Sam68.BIND11278465 
HNRNPKCSBP | FLJ41122 | HNRPK | TUNPheterogeneous nuclear ribonucleoprotein KSam68 interacts with hnRNP KBIND12370808 
Sam68 interacts with hnRNP K. This interaction was modeled on a demonstrated interaction between Sam68 from an unspecified source and human hnRNP K.BIND12370808 
-HPRD,BioGRID12370808 
INSRCD220 | HHF5insulin receptorAffinity Capture-WesternBioGRID11604231 
IRS1HIRS-1insulin receptor substrate 1Affinity Capture-WesternBioGRID11604231 
ITKEMT | LYK | MGC126257 | MGC126258 | PSCTK2IL2-inducible T-cell kinase-HPRD,BioGRID8810341 |8985255 
KHDRBS1FLJ34027 | Sam68 | p62KH domain containing, RNA binding, signal transduction associated 1-HPRD,BioGRID9315629 
KHDRBS3Etle | SALP | SLM-2 | SLM2 | T-STAR | TSTAR | etoileKH domain containing, RNA binding, signal transduction associated 3-HPRD,BioGRID10749975 
LCKYT16 | p56lck | pp58lcklymphocyte-specific protein tyrosine kinase-HPRD,BioGRID9045636 
Lck interacts with Sam68.BIND11278465 
NCF1FLJ79451 | NCF1A | NOXO2 | SH3PXD1A | p47phoxneutrophil cytosolic factor 1Reconstituted ComplexBioGRID8766817 
NCF1CSH3PXD1Cneutrophil cytosolic factor 1C pseudogene-HPRD8766817 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1-HPRD,BioGRID9010224 |9362449 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)Affinity Capture-Western
Reconstituted Complex		BioGRID10467411 |11604231 
Sam68 interacts with the SH2 domains of PI3K p85 alpha. This interaction was modelled based on a demonstrated interaction between two rat proteins.BIND7537265 |10437794 
|11604231 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1-HPRD,BioGRID9743338 
PLCG2-phospholipase C, gamma 2 (phosphatidylinositol-specific)-HPRD10467411 
PRMT1ANM1 | HCP1 | HRMT1L2 | IR1B4protein arginine methyltransferase 1-HPRD,BioGRID12529443 
PTK6BRK | FLJ42088PTK6 protein tyrosine kinase 6-HPRD,BioGRID10913193 
RAPSNCMS1D | CMS1E | MGC3597 | RNF205receptor-associated protein of the synapse-HPRD,BioGRID9804166 
RASA1CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAPRAS p21 protein activator (GTPase activating protein) 1-HPRD,BioGRID11604231 
Sam68 interacts with the SH2 domains of p120GAP, preferentially with the C-terminal SH2 domain. This interaction was modelled based on a demonstrated interaction between rat proteins.BIND11604231 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD,BioGRID1545818 |8766817 
|10467411 
c-Src SH3 domain interacts with Sam68 proline-rich region. This interaction was modelled on a demonstrated interaction between c-Src from an unspecified source and human Sam68.BIND7537265 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)-HPRD,BioGRID11585385 
STUB1CHIP | HSPABP2 | NY-CO-7 | SDCCAG7 | UBOX1STIP1 homology and U-box containing protein 1Two-hybridBioGRID16169070 
TNFSF11CD254 | ODF | OPGL | OPTB2 | RANKL | TRANCE | hRANKL2 | sOdftumor necrosis factor (ligand) superfamily, member 11Biochemical ActivityBioGRID10635328 
TUBB3MC1R | TUBB4 | beta-4tubulin, beta 3Two-hybridBioGRID16169070 
WBP4FBP21 | MGC117310WW domain binding protein 4 (formin binding protein 21)-HPRD,BioGRID10748127 
YTHDC1KIAA1966 | YT521 | YT521-BYTH domain containing 1-HPRD,BioGRID10564280 
 
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1229249301Ahsa-miR-122aUGGAGUGUGACAAUGGUGUUUGU
miR-200bc/429881887m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-203.14554621A,m8hsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-204/21110491055m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-218566572m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-3292352411Ahsa-miR-329brainAACACACCUGGUUAACCUCUUU
miR-34b117411801Ahsa-miR-34bUAGGCAGUGUCAUUAGCUGAUUG
miR-3815258m8hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-4214104161Ahsa-miR-421GGCCUCAUUAAAUGUUUGUUG
miR-433-3p6156211Ahsa-miR-433brainAUCAUGAUGGGCUCCUCGGUGU
miR-491135141m8hsa-miR-491brainAGUGGGGAACCCUUCCAUGAGGA
miR-4965195261A,m8hsa-miR-496AUUACAUGGCCAAUCUC
miR-505739745m8hsa-miR-505GUCAACACUUGCUGGUUUCCUC
miR-544434440m8hsa-miR-544AUUCUGCAUUUUUAGCAAGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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