Gene Page: PLXNA2

Summary
GeneID  5362
Symbol  PLXNA2
Synonyms  FLJ11751|FLJ30634|KIAA0463|OCT|PLXN2
Description  plexin A2
See related  HGNC:9100|MIM:601054|Ensembl:ENSG00000076356|HPRD:03033|
Locus tag  RP11-328D5.3
Gene type  protein-coding
Map location  1q32.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 31 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
RBM50.940.94
PRPF30.930.93
METTL30.930.92
RBM60.920.93
ZNF5090.920.93
HARS20.920.91
ZCCHC80.910.92
ZNF70.910.92
CCNL10.910.92
ZNF2110.910.90
Top 10 negatively co-expressed genes
AF347015.31-0.76-0.87
AF347015.27-0.74-0.85
MT-CO2-0.74-0.85
MT-CYB-0.71-0.82
IFI27-0.71-0.82
AF347015.33-0.71-0.80
AIFM3-0.70-0.73
AF347015.8-0.70-0.83
HLA-F-0.70-0.71
HIGD1B-0.68-0.81
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007165signal transductionIEA-
GO:0007275multicellular organismal developmentIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DHX37DDX37 | FLJ41974 | KIAA1517 | MGC2695 | MGC4322 | MGC46245DEAH (Asp-Glu-Ala-His) box polypeptide 37-HPRD12421765 
HACE1-HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1-HPRD12421765 
IFT80ATD2 | KIAA1374 | MGC126543 | WDR56intraflagellar transport 80 homolog (Chlamydomonas)-HPRD12421765 
KIAA1199TMEM2LKIAA1199-HPRD12421765 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_CRMPS_IN_SEMA3A_SIGNALING 1414All SZGR genes in this pathway
REACTOME_OTHER_SEMAPHORIN_INTERACTIONS 1514All SZGR genes in this pathway
REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION 1514All SZGR genes in this pathway
REACTOME_SEMAPHORIN_INTERACTIONS 6853All SZGR genes in this pathway
REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION 139All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP 191128All SZGR genes in this pathway
HU_ANGIOGENESIS_DN 3725All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_1 4527All SZGR genes in this pathway
KORKOLA_YOLK_SAC_TUMOR 6233All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_DN 514319All SZGR genes in this pathway
KIM_MYC_AMPLIFICATION_TARGETS_DN 9751All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN 637377All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP 487286All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 206136All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
HADDAD_B_LYMPHOCYTE_PROGENITOR 293193All SZGR genes in this pathway
JAZAERI_BREAST_CANCER_BRCA1_VS_BRCA2_DN 4331All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_24HR_UP 14896All SZGR genes in this pathway
BILD_HRAS_ONCOGENIC_SIGNATURE 261166All SZGR genes in this pathway
LEE_METASTASIS_AND_ALTERNATIVE_SPLICING_UP 7451All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_DN 543317All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
CHEN_LIVER_METABOLISM_QTL_CIS 9340All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G1_UP 11370All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
PILON_KLF1_TARGETS_UP 504321All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN 321200All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1 467251All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
DURAND_STROMA_S_UP 297194All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
NABA_ECM_AFFILIATED 17189All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-10149404946m8hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-137117411811A,m8hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-142-5p352358m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-145473047361Ahsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-15/16/195/424/497302308m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-199472847351A,m8hsa-miR-199aCCCAGUGUUCAGACUACCUGUUC
hsa-miR-199bCCCAGUGUUUAGACUAUCUGUUC
miR-214378037871A,m8hsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-26118011871A,m8hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-30-5p116411711A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-3120522058m8hsa-miR-31AGGCAAGAUGCUGGCAUAGCUG
miR-3269298m8hsa-miR-326CCUCUGGGCCCUUCCUCCAG
miR-330305311m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-369-3p474047471A,m8hsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-37447414747m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-378210521111Ahsa-miR-378CUCCUGACUCCAGGUCCUGUGU
miR-410494849551A,m8hsa-miR-410AAUAUAACACAGAUGGCCUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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