Gene Page: GNB1

Summary
GeneID  2782
Symbol  GNB1
Synonyms  -
Description  guanine nucleotide binding protein (G protein), beta polypeptide 1
See related  HGNC:4396|MIM:139380|Ensembl:ENSG00000078369|HPRD:00766|
Locus tag  -
Gene type  protein-coding
Map location  1p36.33
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0114 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
FNDC3A0.900.91
C6orf890.880.90
SEC23IP0.870.88
KIAA00900.870.89
CASC40.870.88
COPA0.870.88
LRBA0.860.88
USP380.860.86
UBE4A0.860.91
FAF20.860.87
Top 10 negatively co-expressed genes
AF347015.21-0.65-0.65
MT-CO2-0.62-0.63
AF347015.31-0.61-0.61
AF347015.8-0.59-0.60
FXYD1-0.59-0.57
AC098691.2-0.58-0.62
HIGD1B-0.58-0.58
AF347015.33-0.57-0.56
C1orf54-0.57-0.62
MT-CYB-0.56-0.56
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004871signal transducer activityIEA-
GO:0003924GTPase activityTAS3095147 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007200G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)IEA-
GO:0007265Ras protein signal transductionTAS8717044 
GO:0007213acetylcholine receptor signaling, muscarinic pathwayTAS8717044 
GO:0007165signal transductionTAS7649993 |8717044 
GO:0008283cell proliferationIEA-
GO:0009755hormone-mediated signalingEXP12626323 
GO:0050909sensory perception of tasteIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005834heterotrimeric G-protein complexIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARHGEF18KIAA0521 | MGC15913rho/rac guanine nucleotide exchange factor (GEF) 18-HPRD,BioGRID14512443 
CACNA1AAPCA | CACNL1A4 | CAV2.1 | EA2 | FHM | HPCA | MHP | MHP1 | SCA6calcium channel, voltage-dependent, P/Q type, alpha 1A subunitAn unspecified isoform of Cav2.1 interacts with G-beta-1. This interaction was modeled on a demonstrated interaction between Cav2.1 and G-beta-1, both from unspecified species.BIND15953418 
CACNA1BBIII | CACNL1A5 | CACNN | Cav2.2calcium channel, voltage-dependent, N type, alpha 1B subunitCav2.2 interacts with G-beta-1. This interaction was modeled on a demonstrated interaction between human Cav2.2 and G-beta-1 from an unspecified species.BIND15953418 
CACNA1CCACH2 | CACN2 | CACNL1A1 | CCHL1A1 | CaV1.2 | MGC120730 | TScalcium channel, voltage-dependent, L type, alpha 1C subunitCav1.2 interacts with G-beta-1. This interaction was modeled on a demonstrated interaction between Cav1.2 and G-beta-1, both from unspecified species.BIND15953418 
DNAJC25bA16L21.2.1DnaJ (Hsp40) homolog, subfamily C , member 25-HPRD7665596 
GNASAHO | C20orf45 | GNAS1 | GPSA | GSA | GSP | MGC33735 | PHP1A | PHP1B | POH | dJ309F20.1.1 | dJ806M20.3.3GNAS complex locusG-beta-1 interacts with G-alpha-s.BIND15782186 
-HPRD11294873 
GNB2L1Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1-HPRD12359736 
GNG10-guanine nucleotide binding protein (G protein), gamma 10Reconstituted ComplexBioGRID7665596 
GNG11GNGT11guanine nucleotide binding protein (G protein), gamma 11-HPRD,BioGRID7665596 
GNG13G(gamma)13 | h2-35guanine nucleotide binding protein (G protein), gamma 13-HPRD,BioGRID10570481 
GNG2-guanine nucleotide binding protein (G protein), gamma 2G-beta-1 interacts with G-gamma-2.BIND15782186 
GNG2 (G-gamma-2) interacts with GNB1 (G-beta-1).BIND15889144 
-HPRD11294873 
GNG3-guanine nucleotide binding protein (G protein), gamma 3-HPRD11294873 
GNG4DKFZp547K1018 | FLJ23803 | FLJ34187guanine nucleotide binding protein (G protein), gamma 4-HPRD,BioGRID7665596 
GNG7FLJ00058guanine nucleotide binding protein (G protein), gamma 7-HPRD,BioGRID8308009 
KCNJ3GIRK1 | KGA | KIR3.1potassium inwardly-rectifying channel, subfamily J, member 3Reconstituted ComplexBioGRID12743112 
PDCLDKFZp564M1863 | PhLPphosducin-likePhLP (PDCL) interacts with GNB1 (G-beta-1).BIND15889144 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CHEMOKINE_SIGNALING_PATHWAY 190128All SZGR genes in this pathway
KEGG_TASTE_TRANSDUCTION 5228All SZGR genes in this pathway
BIOCARTA_CSK_PATHWAY 2420All SZGR genes in this pathway
BIOCARTA_SPPA_PATHWAY 2218All SZGR genes in this pathway
BIOCARTA_AGPCR_PATHWAY 1312All SZGR genes in this pathway
BIOCARTA_BIOPEPTIDES_PATHWAY 4535All SZGR genes in this pathway
BIOCARTA_CCR3_PATHWAY 2321All SZGR genes in this pathway
BIOCARTA_GCR_PATHWAY 2217All SZGR genes in this pathway
BIOCARTA_CXCR4_PATHWAY 2422All SZGR genes in this pathway
BIOCARTA_ERK_PATHWAY 2822All SZGR genes in this pathway
BIOCARTA_FMLP_PATHWAY 3929All SZGR genes in this pathway
BIOCARTA_MPR_PATHWAY 3428All SZGR genes in this pathway
BIOCARTA_EDG1_PATHWAY 2724All SZGR genes in this pathway
BIOCARTA_MYOSIN_PATHWAY 3122All SZGR genes in this pathway
BIOCARTA_BARR_MAPK_PATHWAY 1211All SZGR genes in this pathway
BIOCARTA_BARRESTIN_SRC_PATHWAY 1514All SZGR genes in this pathway
BIOCARTA_GPCR_PATHWAY 3731All SZGR genes in this pathway
BIOCARTA_BARRESTIN_PATHWAY 108All SZGR genes in this pathway
BIOCARTA_PAR1_PATHWAY 3728All SZGR genes in this pathway
PID_LYSOPHOSPHOLIPID_PATHWAY 6653All SZGR genes in this pathway
PID_HDAC_CLASSII_PATHWAY 3427All SZGR genes in this pathway
PID_ER_NONGENOMIC_PATHWAY 4135All SZGR genes in this pathway
PID_TXA2PATHWAY 5743All SZGR genes in this pathway
PID_CXCR4_PATHWAY 10278All SZGR genes in this pathway
PID_THROMBIN_PAR4_PATHWAY 1511All SZGR genes in this pathway
PID_RHODOPSIN_PATHWAY 2410All SZGR genes in this pathway
PID_IL8_CXCR2_PATHWAY 3426All SZGR genes in this pathway
PID_AR_NONGENOMIC_PATHWAY 3127All SZGR genes in this pathway
PID_HEDGEHOG_GLI_PATHWAY 4835All SZGR genes in this pathway
PID_CXCR3_PATHWAY 4334All SZGR genes in this pathway
PID_THROMBIN_PAR1_PATHWAY 4332All SZGR genes in this pathway
PID_IL8_CXCR1_PATHWAY 2819All SZGR genes in this pathway
REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 205136All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_SIGNALING_BY_GPCR 920449All SZGR genes in this pathway
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 12084All SZGR genes in this pathway
REACTOME_OPIOID_SIGNALLING 7856All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 137110All SZGR genes in this pathway
REACTOME_G_PROTEIN_ACTIVATION 2715All SZGR genes in this pathway
REACTOME_OLFACTORY_SIGNALING_PATHWAY 32860All SZGR genes in this pathway
REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 413270All SZGR genes in this pathway
REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION 3423All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 4328All SZGR genes in this pathway
REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS 184116All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION 9365All SZGR genes in this pathway
REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE 2515All SZGR genes in this pathway
REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS 8858All SZGR genes in this pathway
REACTOME_GLUCAGON_TYPE_LIGAND_RECEPTORS 3322All SZGR genes in this pathway
REACTOME_G_ALPHA1213_SIGNALLING_EVENTS 7456All SZGR genes in this pathway
REACTOME_ADP_SIGNALLING_THROUGH_P2RY1 2516All SZGR genes in this pathway
REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA 2012All SZGR genes in this pathway
REACTOME_GPCR_DOWNSTREAM_SIGNALING 805368All SZGR genes in this pathway
REACTOME_G_ALPHA_I_SIGNALLING_EVENTS 195114All SZGR genes in this pathway
REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA 2515All SZGR genes in this pathway
REACTOME_G_ALPHA_S_SIGNALLING_EVENTS 12182All SZGR genes in this pathway
REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS 4429All SZGR genes in this pathway
REACTOME_G_PROTEIN_BETA_GAMMA_SIGNALLING 2818All SZGR genes in this pathway
REACTOME_SIGNAL_AMPLIFICATION 3119All SZGR genes in this pathway
REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR 2314All SZGR genes in this pathway
REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 2110All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_KAINATE_RECEPTORS_UPON_GLUTAMATE_BINDING 3123All SZGR genes in this pathway
REACTOME_GPCR_LIGAND_BINDING 408246All SZGR genes in this pathway
REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS 3220All SZGR genes in this pathway
REACTOME_PLATELET_HOMEOSTASIS 7849All SZGR genes in this pathway
REACTOME_AQUAPORIN_MEDIATED_TRANSPORT 5134All SZGR genes in this pathway
REACTOME_PROSTACYCLIN_SIGNALLING_THROUGH_PROSTACYCLIN_RECEPTOR 1911All SZGR genes in this pathway
REACTOME_REGULATION_OF_WATER_BALANCE_BY_RENAL_AQUAPORINS 4430All SZGR genes in this pathway
REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS 2517All SZGR genes in this pathway
REACTOME_GABA_B_RECEPTOR_ACTIVATION 3826All SZGR genes in this pathway
REACTOME_GABA_RECEPTOR_ACTIVATION 5240All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
REACTOME_POTASSIUM_CHANNELS 9868All SZGR genes in this pathway
REACTOME_INWARDLY_RECTIFYING_K_CHANNELS 3120All SZGR genes in this pathway
REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 208138All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP 332228All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_SKIN_UP 177113All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN 800473All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_UP 227137All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_CIS 12877All SZGR genes in this pathway
CHESLER_BRAIN_QTL_CIS 7551All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_CIS 6538All SZGR genes in this pathway
NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_DN 12179All SZGR genes in this pathway
CHESLER_BRAIN_HIGHEST_GENETIC_VARIANCE 3721All SZGR genes in this pathway
CHESLER_BRAIN_HIGHEST_EXPRESSION 4029All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
IGLESIAS_E2F_TARGETS_UP 151103All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_H2O2 3929All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
RAMALHO_STEMNESS_UP 206118All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
KAYO_AGING_MUSCLE_DN 12376All SZGR genes in this pathway
BURTON_ADIPOGENESIS_8 8657All SZGR genes in this pathway
MCCLUNG_CREB1_TARGETS_UP 10072All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_UP 198132All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_DN 165106All SZGR genes in this pathway
KEEN_RESPONSE_TO_ROSIGLITAZONE_DN 10668All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_DN 249165All SZGR genes in this pathway
IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_UP 12692All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_DN 210128All SZGR genes in this pathway
TOOKER_GEMCITABINE_RESISTANCE_DN 12284All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
MILI_PSEUDOPODIA_CHEMOTAXIS_DN 457302All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP 188121All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_2 277172All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_7 7646All SZGR genes in this pathway
BAUS_TFF2_TARGETS_UP 3222All SZGR genes in this pathway
SASSON_RESPONSE_TO_GONADOTROPHINS_UP 9159All SZGR genes in this pathway
SASSON_RESPONSE_TO_FORSKOLIN_DN 8868All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_M_G1 14895All SZGR genes in this pathway
STAMBOLSKY_RESPONSE_TO_VITAMIN_D3_UP 8448All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
PLASARI_TGFB1_SIGNALING_VIA_NFIC_1HR_DN 10677All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/20638441Ahsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-10117351741m8hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-132/212173717431Ahsa-miR-212SZUAACAGUCUCCAGUCACGGCC
hsa-miR-132brainUAACAGUCUACAGCCAUGGUCG
miR-139104910551Ahsa-miR-139brainUCUACAGUGCACGUGUCU
hsa-miR-139brainUCUACAGUGCACGUGUCU
miR-14528341Ahsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-183101310191Ahsa-miR-183UAUGGCACUGGUAGAAUUCACUG
miR-186124212481Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-218670676m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-324-5p170717131Ahsa-miR-324-5pCGCAUCCCCUAGGGCAUUGGUGU
miR-485-3p9319381A,m8hsa-miR-485-3pGUCAUACACGGCUCUCCUCUCU
miR-493-5p9429491A,m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-542-3p6056111Ahsa-miR-542-3pUGUGACAGAUUGAUAACUGAAA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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