Gene Page: EXOSC10

Summary
GeneID  5394
Symbol  EXOSC10
Synonyms  PM-Scl|PM/Scl-100|PMSCL|PMSCL2|RRP6|Rrp6p|p2|p3|p4
Description  exosome component 10
See related  HGNC:9138|MIM:605960|Ensembl:ENSG00000171824|HPRD:16180|
Locus tag  -
Gene type  protein-coding
Map location  1p36.22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.3979 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
QRICH20.900.91
FBN30.900.88
PXDN0.900.93
ZNF1350.900.90
KIAA13050.900.92
ANKZF10.900.90
NINL0.900.92
ARID3B0.900.92
FANCA0.890.91
MICAL10.890.91
Top 10 negatively co-expressed genes
FBXO2-0.60-0.66
ALDOC-0.59-0.69
C5orf53-0.59-0.75
AIFM3-0.59-0.72
HLA-F-0.59-0.69
ACYP2-0.58-0.66
PTH1R-0.58-0.67
LHPP-0.58-0.57
LDHD-0.58-0.64
S100B-0.58-0.79
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003723RNA bindingIEA-
GO:0004674protein serine/threonine kinase activityTAS1383382 
GO:0016787hydrolase activityIEA-
GO:00084083'-5' exonuclease activityIEA-
GO:0042802identical protein bindingIPI15231747 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decayIEA-
GO:0006396RNA processingIEA-
GO:0006364rRNA processingIEA-
GO:0006139nucleobase, nucleoside, nucleotide and nucleic acid metabolic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000176nuclear exosome (RNase complex)IEA-
GO:0005622intracellularIEA-
GO:0005634nucleusIEA-
GO:0005730nucleolusTAS1383382 
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CIB1CIB | KIP | KIP1 | SIP2-28calcium and integrin binding 1 (calmyrin)-HPRD,BioGRID15231747 
EXOSC1CGI-108 | CSL4 | Csl4p | SKI4 | Ski4p | hCsl4p | p13exosome component 1-HPRD11110791 |12419256 
EXOSC3CGI-102 | MGC15120 | MGC723 | RP11-3J10.8 | RRP40 | Rrp40p | bA3J10.7 | hRrp40p | p10exosome component 3-HPRD11110791 |12419256 
EXOSC4FLJ20591 | RRP41 | RRP41A | Rrp41p | SKI6 | Ski6p | hRrp41p | p12Aexosome component 4-HPRD15231747 
EXOSC5MGC111224 | MGC12901 | RRP41B | RRP46 | Rrp46p | hRrp46p | p12Bexosome component 5-HPRD15231747 
EXOSC6EAP4 | MTR3 | Mtr3p | hMtr3p | p11exosome component 6-HPRD15231747 
MAP3K14FTDCR1B | HS | HSNIK | NIKmitogen-activated protein kinase kinase kinase 14-HPRD14743216 
MPHOSPH6MPP | MPP-6 | MPP6M-phase phosphoprotein 6-HPRD15231747 
MPP6PALS2 | VAM-1 | VAM1 | p55Tmembrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)Two-hybridBioGRID15231747 
PTGES2C9orf15 | FLJ14038 | GBF1 | MGC11289 | PGES2 | mPGES-2prostaglandin E synthase 2Two-hybridBioGRID15231747 
RPEMGC2636 | RPE2-1ribulose-5-phosphate-3-epimeraseTwo-hybridBioGRID15231747 
SCRIBCRIB1 | SCRB1 | SCRIB1 | Vartulscribbled homolog (Drosophila)Two-hybridBioGRID15231747 
TARDBPALS10 | TDP-43TAR DNA binding proteinTwo-hybridBioGRID15231747 
UPF1FLJ43809 | FLJ46894 | HUPF1 | KIAA0221 | NORF1 | RENT1 | pNORF1UPF1 regulator of nonsense transcripts homolog (yeast)Affinity Capture-WesternBioGRID14527413 
UPF2DKFZp434D222 | HUPF2 | KIAA1408 | MGC138834 | MGC138835 | RENT2 | smg-3UPF2 regulator of nonsense transcripts homolog (yeast)Affinity Capture-WesternBioGRID14527413 
UPF3AHUPF3A | RENT3A | UPF3UPF3 regulator of nonsense transcripts homolog A (yeast)Affinity Capture-WesternBioGRID14527413 
USP16UBP-Mubiquitin specific peptidase 16-HPRD,BioGRID15231747 
XRN2-5'-3' exoribonuclease 2-HPRD,BioGRID15231747 
 


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