Gene Page: RYR2

Summary
GeneID  6262
Symbol  RYR2
Synonyms  ARVC2|ARVD2|VTSIP
Description  ryanodine receptor 2 (cardiac)
See related  HGNC:10484|MIM:180902|HPRD:01619|
Locus tag  RP4-626J7.1
Gene type  protein-coding
Map location  1q42.1-q43
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0397 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
AC087071.10.730.44
AL353354.30.700.41
FAM159B0.680.46
SPDYA0.660.49
C17orf840.650.17
AC120053.10.640.49
AL050337.10.630.34
PIGB0.620.39
NOX10.620.42
C1orf610.610.34
Top 10 negatively co-expressed genes
FAM82A2-0.49-0.32
OGDH-0.49-0.40
EPN2-0.47-0.40
CNDP2-0.47-0.36
MYH9-0.47-0.45
LARS2-0.46-0.30
RHOB-0.46-0.31
HSPA9-0.46-0.33
AGPAT3-0.46-0.40
EPM2A-0.45-0.33
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004872receptor activityIEA-
GO:0005509calcium ion bindingIEA-
GO:0005516calmodulin bindingIEA-
GO:0005216ion channel activityIEA-
GO:0005219ryanodine-sensitive calcium-release channel activityIEA-
GO:0015278calcium-release channel activityTAS10830164 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008627induction of apoptosis by ionic changesIDA15044459 
GO:0007165signal transductionNAS10463072 
GO:0008016regulation of heart contractionTAS10830164 
GO:0006816calcium ion transportIEA-
GO:0006811ion transportIEA-
GO:0006936muscle contractionTAS10830164 
GO:0006874cellular calcium ion homeostasisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneTAS10830164 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKAP6ADAP100 | ADAP6 | AKAP100 | KIAA0311 | MGC165020 | PRKA6 | mAKAPA kinase (PRKA) anchor protein 6-HPRD,BioGRID11352932 
CACNA1CCACH2 | CACN2 | CACNL1A1 | CCHL1A1 | CaV1.2 | MGC120730 | TScalcium channel, voltage-dependent, L type, alpha 1C subunit-HPRD,BioGRID11576544 
FKBP1BFKBP12.6 | FKBP1L | OTK4 | PKBP1L | PPIaseFK506 binding protein 1B, 12.6 kDa-HPRD,BioGRID10830164 |12443530 
|12446682 
HOMER1HOMER | HOMER1A | HOMER1B | HOMER1C | SYN47 | Ves-1homer homolog 1 (Drosophila)-HPRD,BioGRID12887973 
PPP1CAMGC15877 | MGC1674 | PP-1A | PPP1Aprotein phosphatase 1, catalytic subunit, alpha isoformCo-fractionationBioGRID10830164 
PPP1CBMGC3672 | PP-1B | PPP1CDprotein phosphatase 1, catalytic subunit, beta isoformCo-fractionationBioGRID10830164 
PPP1CCPPP1Gprotein phosphatase 1, catalytic subunit, gamma isoformCo-fractionationBioGRID10830164 
PRKACAMGC102831 | MGC48865 | PKACAprotein kinase, cAMP-dependent, catalytic, alphaBiochemical Activity
Co-fractionation		BioGRID10830164 
PRKACBDKFZp781I2452 | MGC41879 | MGC9320 | PKACBprotein kinase, cAMP-dependent, catalytic, betaBiochemical Activity
Co-fractionation		BioGRID10830164 
PRKACGKAPG | PKACgprotein kinase, cAMP-dependent, catalytic, gammaBiochemical Activity
Co-fractionation		BioGRID10830164 
PRKAR2AMGC3606 | PKR2 | PRKAR2protein kinase, cAMP-dependent, regulatory, type II, alpha-HPRD,BioGRID10830164 
PRKAR2BPRKAR2 | RII-BETAprotein kinase, cAMP-dependent, regulatory, type II, betaCo-fractionationBioGRID10830164 
RYR1CCO | MHS | MHS1 | RYDR | RYR | SKRRryanodine receptor 1 (skeletal)-HPRD,BioGRID12213830 
RYR2ARVC2 | ARVD2 | VTSIPryanodine receptor 2 (cardiac)Co-fractionationBioGRID10830164 
RYR3-ryanodine receptor 3-HPRD,BioGRID12213830 
SRIFLJ26259 | SCNsorcin-HPRD,BioGRID7592856 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_CARDIAC_MUSCLE_CONTRACTION 8051All SZGR genes in this pathway
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 8565All SZGR genes in this pathway
KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 7659All SZGR genes in this pathway
KEGG_DILATED_CARDIOMYOPATHY 9268All SZGR genes in this pathway
BIOCARTA_NO1_PATHWAY 3324All SZGR genes in this pathway
PIEPOLI_LGI1_TARGETS_UP 1511All SZGR genes in this pathway
DELYS_THYROID_CANCER_DN 232154All SZGR genes in this pathway
MODY_HIPPOCAMPUS_POSTNATAL 6350All SZGR genes in this pathway
LEIN_NEURON_MARKERS 6945All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_DN 264159All SZGR genes in this pathway
VANASSE_BCL2_TARGETS_UP 4025All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3 349234All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K27ME3 341243All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.1463469m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5064624691A,m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-129-5p8108171A,m8hsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
miR-137110711141A,m8hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-153486492m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-204/2114524581Ahsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-221/2224154211Ahsa-miR-221brainAGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brainAGCUACAUCUGGCUACUGGGUCUC
miR-3758698751Ahsa-miR-375UUUGUUCGUUCGGCUCGCGUGA
miR-4488548601Ahsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-4508108161Ahsa-miR-450UUUUUGCGAUGUGUUCCUAAUA
miR-485-3p7907971A,m8hsa-miR-485-3pGUCAUACACGGCUCUCCUCUCU
miR-544489495m8hsa-miR-544AUUCUGCAUUUUUAGCAAGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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